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Oxamisole hydrochloride, PR-879317A

奥沙米索Chemical Name: 2,3,5,6,7,8-Hexahydro-2-phenyl-8,8-dimethoxyimidazo[1,2-a]pyridine hydrochloride
CAS No. 99258-56-7 (free base), 99258-55-6 (monoHCl)
项目整合开发状态: Phase I
项目研究机构: Pennwalt (Originator)
合成路线:The reaction of 2-phenyl-2,3,5,6,7,8-hexahydro imidazo[1,2-a]pyridine (I) with diphenyl sulfide (II) by means of n-butyllithium in THF gives 2-phenyl-8-(phenylthio)-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridine (III),which is then oxidized with chloramine T in methanol and simultaneously ketalized.
📌 参考资料/链接:
参考文献标题:Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine
文献作者:Davidson,T.A.; Murray,R.J.(Pennwalt Corp.)
参考来源:EP 0150255; US 4507481

📄 详细内容


合成路线:The reaction of 2-phenyl-2,3,5,6,7,8-hexahydro imidazo[1,2-a]pyridine (I) with diphenyl sulfide (II) by means of n-butyllithium in THF gives 2-phenyl-8-(phenylthio)-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridine (III),which is then oxidized with chloramine T in methanol and simultaneously ketalized.

参考文献标题:PR-879317A
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1988,13(10),934


合成路线:The reaction of 2-phenyl-2,3,5,6,7,8-hexahydro imidazo[1,2-a]pyridine (I) with diphenyl sulfide (II) by means of n-butyllithium in THF gives 2-phenyl-8-(phenylthio)-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridine (III),which is then oxidized with chloramine T in methanol and simultaneously ketalized.
参考文献标题:Immunomodulatory pyrrolo[1,2-a]imidazoles and imidazol[1,2-a]pyridines
文献作者:Murray,R.J.; Loch,J.T.III; Radov,L.A.; Davidson,T.A.; Kamp,D.; Trusso,L.A.; Gawlack,D.L.
参考来源:192nd ACS Natl Meet (Sept 7-12,Anaheim) 1986,Abst MEDI-81


产品链接: CAS No. 99258-56-7››

产品链接: CAS No.99258-55-6››