项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Eberconazole , WAS-2160

依柏康唑硝酸依柏康唑 Chemical Name: (?-1-(2,4-Dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1H-imidazole
CAS No. 128326-82-9, 130104-32-4 (nitrate)
项目整合开发状态: Pre-Registered
项目研究机构: Soc. Esp....
参考文献标题:Dichlorosubstd.imidazole derivs.as antifungal agents
文献作者:Andreoli Rovati,R.; Cepero Mestres,R.(Sociedad Espa駉la de Especialidades Farmaco-Terap閡ticas SA)
参考来源:AU 9052554; EP 0392326; US 5177099

alpha-Difluoromethylornithine hydrochloride, Eflornithine hydrochloride, MDL-71782A, RMI-71782, DFMO, Vaniqa, Ornidyl

依氟鸟氨酸盐酸盐一水合物依氟鸟氨酸 Chemical Name: 2-Difluoromethyl-DL-ornithine monohydrochloride monohydrate; 2-Difluoromethyl-2,5-diaminopentanoic acid monohydrochloride monohydrate
CAS No. 96020-91-6, 67037-37-...
参考文献标题:2-(Difluoromethyl)-2,5-diaminopentanoic acid
文献作者:Jung,M.; Bey,P.(Aventis Pharma SA)
参考来源:US 4413141

Exatecan mesilate, DX-8951f, DX-8951(free base)

依沙替康甲磺酸盐依喜替康依沙替康甲磺酸盐水合物Chemical Name: (1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione mesylate 参考文献标题:Hexacyclic cpd.
文献作者:Terasawa,H.; Ejima,A.; Ohsuki,S.; Uoto,K.(Daiichi Pharmaceutical Co.,Ltd.; Yakult Honsha Co.,Ltd.)
参考来源:EP 0495432; JP 1993059061; US 5834476; US 6407115

Efaroxan, RX-821037(HCl)

依法克生依法克生盐酸盐 Chemical Name: (?-2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-2-imidazoline; (?-2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole
CAS No. 89197-32-0, 89197-00-2 (HCl)
项目整合...
参考文献标题:alpha-Adrenoceptor reagents.2.Effects of modification of the 1,4-benzodioxan ring system on alpha-adrenoreceptor activity
文献作者:Chapleo,C.B.; et al.
参考来源:J Med Chem 1984,27(5),570-6

Epanolol, ICI-141292, Visacor

依泮洛尔Chemical Name: N-[2-[3-(2-Cyanophenoxy)-2-hydroxypropylamino]ethyl]-2-(4-hydroxyphenyl)acetamide
CAS No. 86880-51-5
项目整合开发状态: Registered-1992
项目研究机构: AstraZeneca (Originator), Taisho (Lic...
参考文献标题:Alkanolamine derivatives
文献作者:Smith,L.H.(AstraZeneca plc)
参考来源:BE 0872820; FR 2412521; GB 1573359

Ezetimibe, SCH-58235, Ezetrol, Zetia

依泽替米贝依折麦布(3R)-异构体 Chemical Name: 1-(4-Fluorophenyl)-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)azetidin-2-one
CAS No. 163222-33-1, 163380-16-3 ([3R-[3alpha(R*),4beta]]-isom...
参考文献标题:Hydroxy-substd.azetidinone cpds.useful as hypocholesterolemic agents
文献作者:Rosenblum,S.B.; Dugar,S.; Burnett,D.A.; Clader,J.W.; McKittrick,B.A.(Schering Corp.)
参考来源:EP 0720599; JP 1996509989; US 5631365; WO 9508532

Eterobarb, RMI-16238, DMNP, EX 12-095, Antilon

依特比妥Chemical Name: 1,3-Bis(methoxymethyl)-5-ethyl-5-phenyl-2,4,6-(1H,3H,5H)-pyrimidinetrione; 1,3-Bis(methoxymethyl)-5-ethyl-5-phenylbarbituric acid; 1,3-Bis(methoxymethyl)phenobarbital
CAS No. 275...
参考文献标题:Krampflende Verbindungen
文献作者:Samour,C.M.; et al.(The Kendall Company)
参考来源:DE 1939787; ES 370220; FR 2015091; GB 1276386

Loteprednol etabonate, IDR-90102(topical), IDR-90103(oral formulation), CDDD-5604, HGP-1, P-5604, Locort, Loterox, Alrex, Lotemax, Lenoxin

依碳氯替泼诺氯替泼诺 Chemical Name: 11beta,17-Dihydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylic acid chloromethyl ester 17-(ethylcarbonate); 17alpha-(Ethoxycarbonyloxy)-11beta-hydroxy-3-oxoandrosta-1,4-diene...
参考文献标题:Steroids with antiinflammatory activity
文献作者:Bodor,N.S.(N.S.Bodor)
参考来源:BE 0889563; US 4996335

Ecopipam, Sch-39166

依考匹泮5H-苯并[d]萘[2,1-b]阿氮平-12-醇,11-氯-6,6a,7,8,9,13b-六氢-7-甲基,转Chemical Name: (-)-(6aS,13bR)-11-Chloro-12-hydroxy-7-methyl-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphtho[2,1-d]azepine
CAS No. 112108-01-7, ...
参考文献标题:Fused benzazepines
文献作者:Berger,J.G.; Clader,J.W.; Chang,W.K.; Gold,E.H.(Schering Corp.)
参考来源:EP 0230270; EP 0254737; JP 1988502348; WO 8704430

Emorfazone, M-73101, Pentoil

依莫法宗Chemical Name: 4-Ethoxy-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinone; 4-Ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone
CAS No. 38957-41-4
项目整合开发状态: Launched-1984
项目研究机构: Morishita (Orig...
参考文献标题:M-73101
文献作者:Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1978,3(10),756