合成路线:Compound can be prepared in two different ways:1) The condensation of 4,5-dichloro-2-methyl-3-(2H)pyridazinone (I) with morpholine (A) in refluxing ethanol gives 2-methyl-4-chloro-5-morpholino-3(2H)-pyridazinone (II),which is then treated with sodium ethoxide in refluxing ethanol.2) The reaction of 2-methyl-4,6-dichloro-5-morpholino-3(2H)pyridazinone (III) with sodium ethoxide in refluxing ethanol gives 2-methyl-4-ethoxy-5-morpholino-6-chloro-3(2H)-pyridazinone (IV),which is then reduced with H2 over Pd/C in THF.
参考文献标题:2-Alkyl-4-alkoxy-5-morpholino-3-2H-pyridazinones and their method of preparation
文献作者:Satoda,I.; et al.
参考来源:GB 1351569
合成路线:Compound can be prepared in two different ways:1) The condensation of 4,5-dichloro-2-methyl-3-(2H)pyridazinone (I) with morpholine (A) in refluxing ethanol gives 2-methyl-4-chloro-5-morpholino-3(2H)-pyridazinone (II),which is then treated with sodium ethoxide in refluxing ethanol.2) The reaction of 2-methyl-4,6-dichloro-5-morpholino-3(2H)pyridazinone (III) with sodium ethoxide in refluxing ethanol gives 2-methyl-4-ethoxy-5-morpholino-6-chloro-3(2H)-pyridazinone (IV),which is then reduced with H2 over Pd/C in THF.
参考文献标题:Verfahren zur Herstellung von 2-Alkyl-4-alkoxy-5-morpholino-3(2H)-pyridazinon
文献作者:Satoda,I.; et al.
参考来源:DE 2225218
合成路线:Compound can be prepared in two different ways:1) The condensation of 4,5-dichloro-2-methyl-3-(2H)pyridazinone (I) with morpholine (A) in refluxing ethanol gives 2-methyl-4-chloro-5-morpholino-3(2H)-pyridazinone (II),which is then treated with sodium ethoxide in refluxing ethanol.2) The reaction of 2-methyl-4,6-dichloro-5-morpholino-3(2H)pyridazinone (III) with sodium ethoxide in refluxing ethanol gives 2-methyl-4-ethoxy-5-morpholino-6-chloro-3(2H)-pyridazinone (IV),which is then reduced with H2 over Pd/C in THF.
参考文献标题:
文献作者:Satoda,I.; et al.
参考来源:JP 7224030
合成路线:Compound can be prepared in two different ways:1) The condensation of 4,5-dichloro-2-methyl-3-(2H)pyridazinone (I) with morpholine (A) in refluxing ethanol gives 2-methyl-4-chloro-5-morpholino-3(2H)-pyridazinone (II),which is then treated with sodium ethoxide in refluxing ethanol.2) The reaction of 2-methyl-4,6-dichloro-5-morpholino-3(2H)pyridazinone (III) with sodium ethoxide in refluxing ethanol gives 2-methyl-4-ethoxy-5-morpholino-6-chloro-3(2H)-pyridazinone (IV),which is then reduced with H2 over Pd/C in THF.
参考文献标题:
文献作者:Kishikawa,T.; Matsuo,T.
参考来源:JP 7659882
产品链接: CAS No. 38957-41-4››