项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Cicloprolol hydrochloride, SL-7517710

倍他洛尔环丙洛尔 Chemical Name: (?-1-[4-[2-(Cyclopropylmethoxy)ethoxy]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hydrochloride; (?-1-[p-[2-Cyclopropylmethoxy)ethoxy]phenoxy]-3-(isopropylamino)-2-propanol h...
参考文献标题:Cicloprolol Hydrocloride
文献作者:Leclerc,G.
参考来源:Drugs Fut 1985,10(12),975

Clentiazem maleate, TA-3090, Logna

克仑硫卓马来酸盐克仑硫卓 Chemical Name: (+)-(2S,3S)-3-Acetoxy-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one maleate
CAS No. 96128-92-6, 96125-53-0 (free base...
参考文献标题:Synthesis of halogen-substituted 1,5-benzothiazepine derivatives and their vasodilating and hypotensive activities
文献作者:Inoue,H.; Konda,M.; Hashiyama,T.; et al.
参考来源:J Med Chem 1991,34(2),675-87

Clinofibrate, S-8527, Lipoclin

克利贝特Chemical Name: [Cyclohexylidenebis(4,1-phenyleneoxy)]bis(2-butyl-2-carboxylic acid); 2,2'-[Cyclohexylidenebis(4,1-phenyleneoxy)]bis(2-methylbutyric acid)
CAS No. 30299-08-2
项目整合开发状态: Launche...
参考文献标题:S-8527
文献作者:Roberts,P.J.; Castar,J.
参考来源:Drugs Fut 1977,2(5),328

Clevudine, Levovir, L-FMAU

克拉夫定Chemical Name: 1-(2'-Deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil; 1-(2'-Deoxy-2'-fluoro-beta-L-arabinofuranosyl)thymine
CAS No. 163252-36-6
项目整合开发状态: Discontinued
项目研究机构: Univ...
参考文献标题:New synthesis of L-FMAU from L-arabinose
文献作者:Sznaidman,M.L.; Almond,M.R.; Pesyan,A.
参考来源:Nucleosides Nucleotides Nucleic Acids 2002,21(2),155

Clinprost, Lipo-isocarbacyclin methyl ester, Lipo PGI2, TEI-9090, TTC-909(lipid microsphere formulation), Lipocurren, Arteon

克林前列素Chemical Name: (1S,5R,6R,7R)-5-[7-Hydroxy-6-[3(S)-hydroxy-1(E)-octenyl]bicyclo[3.3.0]oct-2-en-3-yl]pentanoic acid methyl ester; Lipo-isocarbacyclin methyl ester; (+)-(3aS,5R,6R,6aS)-1,3a,4,5,6,6a...
参考文献标题:Prostacyclines and process for their preparation
文献作者:Ikegami,S.; Kurozumi,S.(Teijin Ltd.)
参考来源:EP 0134246

Clofarabine, CAFdA, 2-Cl-2'-F-araA, Clofarex

克罗拉滨Chemical Name: 2-Chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
CAS No. 123318-82-1
项目整合开发状态: Pre-Registered
项目研究机构: Bioenvision (Orphan Drug), Ilex Oncology (Orphan Drug), ...
参考文献标题:2-Halo-9-(2-deoxy-2-fluoro-B-D-arabinofuranosyl) adenine nucleoside derivs.
文献作者:Montgomery,J.A.; Secrist,J.A.III (Southern Research Institute)
参考来源:JP 1993502014; US 5034518; WO 9014352

Lanperisone hydrochloride, NK-433

兰吡立松盐酸盐兰吡立松 Chemical Name: (-)-2(R)-Methyl-3-(1-pyrrolidinyl)-1-[4-(trifluoromethyl)phenyl]propanone hydrochloride
CAS No. 116287-13-9, 116287-14-0 (free base)
项目整合开发状态: Phase III
项目研究机构: Ni...
参考文献标题:An optically active propanone deriv.and process for producing the same and use thereof
文献作者:Shiozawa,A.; Ishikawa,M.; Sugimura,H.; Yamamoto,H.; Sakasai,T.; Ohtsuki,K.; Kurashige,S.(Nippon Kayaku Co.,Ltd.)
参考来源:EP 0266577; JP 1989131171

Landiolol, Ono-1101, Onoact

兰地洛尔盐酸兰地洛尔 Chemical Name: (-)-3-[4-[2(S)-Hydroxy-3-[2-(morpholinocarboxamido)ethylamino]propoxy]phenyl]propionic acid 2,2-dimethyl-1,3-dioxolan-4(S)-yl ester
CAS No. 133242-30-5, 144481-98-1 (mono...
参考文献标题:Novel esters of phenylalkanoic acid
文献作者:Iguchi,S.; Kawamura,M.; Miyamoto,T.(Ono Pharmaceutical Co.,Ltd.)
参考来源:EP 0397031; JP 1991072475; JP 1994073044; US 5013734

Lansoprazole, AG-1749, ABT-006, CG-4801, A-65006, Ogast, Lanzor, Lanzo, Agopton, Opiren, Bamalite, Takepron, Lansox, Lansox, Ogastro, Monolitum, Prevacid, Zoton

兰索拉唑Chemical Name: 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethylsulfinyl]-1H-benzimidazole; 2-(2-Benzimidazolylsulfinylmethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine
CAS No. 103577-45...
参考文献标题:Pyridine derivs.and their production
文献作者:Nohara,A.; Maki,Y.(Takeda Chemical Industries,Ltd.)
参考来源:AU 8545895; EP 0174726; ES 8607288; JP 1986050978; US 4628098; US 4689333

Nepicastat hydrochloride, RS-25560-197

内匹司他盐酸盐 5-(氨甲基)-1-((S)-5,7-二氟-1,2,3,4-四氢-2-萘)-4-咪唑啉-2-硫酮 Chemical Name: 5-(Aminomethyl)-1-[5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2(S)-yl]-2,3-dihydro-1H-imidazole-2-thione hydrochloride
CAS No....
参考文献标题:Benzocycloalkylazolethione derivs.
文献作者:Martinez,G.R.; Repke,D.B.; Teitelbaum,P.J.; Walker,K.A.M.; Gooding,O.W.; Whiting,R.L.; Bansal,R.P.; Muehldorf,A.V.(Syntex (USA),Inc.)
参考来源:JP 1997512269; US 5438150; WO 9529165