项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Etodolic acid, Etodolac, RAK-591, AY-24236, Lodine SR, Lodine XL, Osteluc, Hypen, Edolan, Ultradol, Lodine

依托度酸Chemical Name: 1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
CAS No. 41340-25-4
项目整合开发状态: Launched-1985
项目研究机构: Shire Pharmaceuticals (Proprietary), Wyeth Pharmaceutical...
参考文献标题:Etodolic acid
文献作者:Castar,J.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1977,2(1),21

Etoposide, VP-16, VP-16-213, NSC-141540, EPEG, Etopophos, Lastet, Etosid, Vepeside, Etopol, Vepesid

依托泊苷Chemical Name: 4'-Demethylepipodophyllotoxin 4-(4,6-O-ethylidene-beta-D-glucopyranoside); [5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-9-[(4,6-O-Ethylidene-beta-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro...
参考文献标题:Etoposide
文献作者:Cabanillas,F.
参考来源:Drugs Fut 1979,4(4),257

Etoposide phosphate disodium salt, BMY-40481(free acid), BMY-40481-30, Etopophos

依托泊苷磷酸二钠依托泊苷磷酸酯 Chemical Name: Etoposide 4'-phosphate disodium salt; [5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-5-[3,5-Dimethoxy-4-(phosphonooxy)phenyl]-9-[(4,6-O-ethylidene-beta-D-gluocopyranosyl)oxy]-5...
参考文献标题:Epipodophyllotoxinglucoside-4'phosphate derivs
文献作者:Saulnier,M.G.; Senter,P.D.; Kadow,J.F.(Bristol-Myers Squibb Co.)
参考来源:AU 8820306; BE 1002982; CH 676716; DE 3826562; FR 2622193; GB 2207674; US 4904768

Etoricoxib, MK-663, MK-0663, L-791456, Nucoxia, Arcoxia

依托考昔 5-氯-3-(4-甲基磺酰基)苯基-2-(2-甲基-5-吡啶基)吡啶盐酸盐 Chemical Name: 5-Chloro-3-[4-(methylsulfonyl)phenyl]-2-(6-methylpyridin-3-yl)pyridine; 5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
CAS...
参考文献标题:Substd.pyridines as selective cyclooxygenase-2 inhibitors
文献作者:Dube,D.; Fortin,R.; Friesen,R.; Wang,Z.; Gauthier,J.Y.(Merck Frosst Canada Inc.)
参考来源:EP 0912518; JP 1999514008; US 5861419; WO 9803484

Eptastigmine tartrate, Heptylstigmine tartrate, L-693487, MF-201

依斯的明Chemical Name: (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol heptylcarbamate ester L-tartrate
CAS No. 101246-68-8 (free base)
项目整合开发状态: Phase III
项目研究机构: Medi...
参考文献标题:HEPTYLSTIGMINE TARTRATE
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(2),123

Exifone, Adlone

依昔苯酮Chemical Name: 2,3,3',4,4',5'-Hexahydroxybenzophenone; (2,3,4-Trihydroxyphenyl)(3,4,5-trihydroxyphenyl)methanone
CAS No. 52479-85-3
项目整合开发状态: Withdrawn-1989
项目研究机构: Pharmascience (Canada)...
参考文献标题:Diphenyl-substd.cpd.compsns.
文献作者:Gazave,J.-M.; Grenier,G.; Rancurel,A.(Laboratoires Pharmascience)
参考来源:DE 2501443; US 4015017

Epoxymexrenone, Eplerenone, CGP-30083, SC-66110, Inspra

依普利酮Chemical Name: 9alpha,11alpha-Epoxy-3,5'-dioxospiro[androst-4-ene-17,2'(R)-tetrahydrofuran]-7alpha-carboxylic acid methyl ester; 9alpha,11alpha-Epoxy-17beta-hydroxy-3-oxo-17alpha-pregn-4-ene-7alph...
参考文献标题:20-Spiroxanes and analogues having an open ring E,processes for their manufacture,and pharmaceutical preparations thereof
文献作者:Grob,J.; Kaldova,J.(Novartis AG)
参考来源:EP 0122232; ES 8602846; ES 8705459; ES 8705460; ES 8705461; JP 1984231100; US 4559332

Osteoquine, Ipriflavone, TN-39, TC-80, FL-113, Osteochin, Iprosten, Osteofix, Osten

依普黄酮Chemical Name: 7-Isopropoxyisoflavone; 7-Isopropoxy-3-phenylchromone; 7-(1-Methylethoxy)-3-phenyl-4H-1-benzopyran-4-one
CAS No. 35212-22-7
项目整合开发状态: Launched-1988
项目研究机构: Chinoin (Origina...
参考文献标题:Ipriflavone
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.; Hillier,K.
参考来源:Drugs Fut 1979,4(11),812

Etretinate, Ro-10-9359, Tegison

依曲替酯Chemical Name: (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid ethyl ester
CAS No. 54350-48-0
项目整合开发状态: Withdrawn
项目研究机构: Roche (Originator)
合成路线:T...
参考文献标题:RO 10/9359
文献作者:Castar,J.; Thorpe,P.
参考来源:Drugs Fut 1977,2(3),199

Eletriptan, UK-116044-04(HBr salt), UK-116044, Relpax

依来曲普坦Chemical Name: 5-[2-(Benzenesulfonyl)ethyl]-3-[1-methylpyrrolidin-2(R)-ylmethyl]-1H-indole
CAS No. 143322-58-1, 143577-61-1 (hemisuccinate), 179041-30-6 (monofumarate), 177834-92-3 (monoHBr sa...
参考文献标题:Indole derivs
文献作者:Macor,J.E.; Wythes,M.J.(Pfizer Inc.)
参考来源:EP 0592438; JP 1993507288; JP 1997003063; US 5545644; WO 9206973