合成路线:1,2-Epoxy-3-(2-cyanophenoxy)propane (I) is added to one equivalent of N-(2-aminoethyl)-4-benzyloxyphenylacetamide (II) in n-propanol and heated to reflux for 18 h,giving N-[2-(3-o-cyanophenoxy-2-hydroxypropylamino)ethyl]-4-benzyloxyphenylacetamide (III).Hydrogenolysis of the 4-benzyl moiety of (III) may be performed under mild conditions (e.g.,hydrogen gas with palladium on carbon in ethanol at room temperature) to yield ICI-141292.
参考文献标题:Epanolol
文献作者:Pento,J.T.; Day,B.W.
参考来源:Drugs Fut 1985,10(5),392
合成路线:1,2-Epoxy-3-(2-cyanophenoxy)propane (I) is added to one equivalent of N-(2-aminoethyl)-4-benzyloxyphenylacetamide (II) in n-propanol and heated to reflux for 18 h,giving N-[2-(3-o-cyanophenoxy-2-hydroxypropylamino)ethyl]-4-benzyloxyphenylacetamide (III).Hydrogenolysis of the 4-benzyl moiety of (III) may be performed under mild conditions (e.g.,hydrogen gas with palladium on carbon in ethanol at room temperature) to yield ICI-141292.
合成路线:The condensation of 1-(2-cyanophenoxy)-2,3-epoxypropane (I) with ethylenediamine (II) gives 1-(2-cyanophenoxy)-3-(2-aminoethylamino)-2-propanol (III),which is finally treated with phenyl isocyanate (IV) in acetonitrile.
参考文献标题:Beta-adrenergic blocking agents.22.1-Phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols
文献作者:Large,M.S.; Smith,L.H.
参考来源:J Med Chem 1982,25(11),1286
产品链接: CAS No. 86880-51-5››