合成路线:The oxidation of 11beta,17,21-trihydroxypregnan-1,4-diene-3,20-dione (I) with sodium metaperiodate in THF/methanol gives 11beta,17alpha-dihydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylic acid (II),which is treated with ethyl chloroformate and triethylamine in dichloromethane yielding 17alpha-(ethoxycarbonyloxy)-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylic acid (III).Finally,this compound is esterified with chloromethyl iodide and NaOH in methanol/water.
参考文献标题:Soft drugs - 10.Blanching activity and receptor binding affinity of a new type of glucocorticoid: Loteprednol etabonate
文献作者:Druzgala,P.; Hochhaus,G.; Bodor,N.
参考来源:J Steroid Biochem Mol Biol 1991,38(2),149-154
合成路线:The oxidation of 11beta,17,21-trihydroxypregnan-1,4-diene-3,20-dione (I) with sodium metaperiodate in THF/methanol gives 11beta,17alpha-dihydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylic acid (II),which is treated with ethyl chloroformate and triethylamine in dichloromethane yielding 17alpha-(ethoxycarbonyloxy)-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylic acid (III).Finally,this compound is esterified with chloromethyl iodide and NaOH in methanol/water.
参考文献标题:Loteprednol Etabonate
文献作者:Graul,A.; Martin,L.; Castar,J.
参考来源:Drugs Fut 1997,22(10),1086
产品链接: CAS No. 82034-46-6›› 产品链接: CAS No.129260-79-3››