项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Tafenoquine succinate, Etaquine, SB-252263, WR-238605

他非诺喹琥珀酸盐他非诺喹 Chemical Name: (?-8-(4-Amino-1-methylbutylamino)-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline succinate; (?-2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]primaquin...
参考文献标题:4-Methyl-5-(unsubstd.and substd.phenoxy)-6-methoxy-8-(aminoalkylamino)quinolines
文献作者:LaMontagne,M.P.; Strube,R.E.(Department of the Army)
参考来源:US 4431807

Itasetron, DAU6215CL, U-98079A, DAU-6215

伊他司琼 1H-苯并咪唑-1-羧酰胺,2,3-二氢铄-[(3-endo)-8-甲基-8-阿氮双环[3.2.1]辛-3-基]-2-氧合-,单盐酸盐(9CI) Chemical Name: N-(endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxamide; 2-Oxo-N-(1a...
参考文献标题:Azabicycloalkyl benzimidazolone derivatives: A novel class of 5-HT3 receptor antagonists
文献作者:Turconi,M.; et al.
参考来源:199th ACS Natl Meet (April 22 1990,Boston) 1990,Abst MEDI 103

Itazogrel, Itazigrel, U-53059, TFT

伊他格雷Chemical Name: 4,5-Bis(4-methoxyphenyl)-2-trifluoromethylthiazole
CAS No. 70529-35-0
项目整合开发状态: Phase II
项目研究机构: Pfizer (Originator)
合成路线:The amonolysis of trifluoroacetonitrile (I) in ...
参考文献标题:TFT
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1982,7(5),323

Ivarimod, Ru-18492

伊伐莫德Chemical Name: N-(2-Hydroxyethyl)maleopimarimidyl morpholide; 4-[[(3aR,3bS,5aR,6R,9aR,9bR,11R,11aR)-1,2,3,3a,4,5,,5a,6,7,8,9,9a,9b,10,11,11a-Hexadecahydro-2-(2-hydroxyethyl)-12-isopropyl-6,9a-dime...
参考文献标题:Novel derivatives of maleopimaric acid
文献作者:Taylor,J.B.; et al.(Aventis Pharma SA)
参考来源:DE 2351343; FR 2202691; GB 1417996; JP 49093356; US 3998823

Ecabet sodium, TA-2711E, TA-2711, Gastrom

伊卡倍特钠(1R,4aS,10aR)-7-异丙基-1,4a-二甲基-6-磺基-1,2,3,4,4a,9,10,10a-八氢菲-1-羧酸Chemical Name: 12-Sulfodehydroabietic acid monosodium salt; [1R-(1alpha,4abeta,10aalpha)]-7-Isopropyl-1,4a-dimethyl-6-sulfo-1,2,3,4,4...
参考文献标题:TA-2711
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(11),966

PST-2744

伊司他肟Chemical Name: 3-(2-Aminoethoxyimino)-5alpha-androstane-6,17-dione; 5-alpha-Androstane-3,6,17-trione 3-[O-(2-aminoethyl)oxime]
CAS No. 203737-93-3, 203738-46-9 (E-isomer), 203737-94-4 (oxalate ...
参考文献标题:New 6-hydroxy and 6-oxo-andro-stane derivs.active on the cardiovascular system and pharmaceutical compsns.containing the same
文献作者:De Munari,S.; Folpini,E.; Frigerio,M.; Melloni,P.; Serra,F.; Sputore,S.(Sigma-Tau Industrie Farmaceutiche Riunite SpA)
参考来源:DE 19633349; EP 0825197; JP 1998077292

Olanexidine hydrochloride, OPB-2045

伊咪多二碳酰胺,N-[(3,4-二氯苯基)甲基]-N'-辛基,盐酸盐(1:1) 奥兰西丁伊咪多二碳酰胺,N-[(3,4-二氯苯基)甲基]-N'-辛基,盐酸盐,水合物(2:2:1)Chemical Name: 1-(3,4-Dichlorobenzyl)-5-octylbiguanide hydrochloride
CAS No. 146509-94-6, 146510-36-3 (free...
参考文献标题:Biguanide derivs.,manufacturing method thereof,and disinfectants containing the derivs.
文献作者:Ishikawa,H.; Yasumura,K.; Tsubouchi,H.; Higuchi,Y.; Tamaoka,H.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:EP 0507317

Ipenoxazone, MLV-6976, NC-1200

伊培沙宗Chemical Name: (+)-(4S,5R)-4-(2-Methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl-1,3-oxazolidin-2-one
CAS No. 104454-71-9
项目整合开发状态: Phase II
项目研究机构: Nippon Chemiphar (Originator)<...
参考文献标题:1,3-Oxazolidin-2-one derivs.
文献作者:Moritoh,N.; Satoh,M.; Shinozaki,H.; Masaki,M.; Hashimoto,K.; Kamishiro,T.(Nippon Chemiphar Co.,Ltd.)
参考来源:CH 663207; DE 3519261; ES 8800571; ES 8802152; FR 2571052; GB 2165237; JP 1986083170; US 4644063

Ipamorelin, NSAC, NNC-26-0161

伊帕瑞林Chemical Name: 2-Methyl-alanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenyalanyl-L-lysinamide
CAS No. 170851-70-4
项目整合开发状态: Phase I
项目研究机构: Novo Nordisk (Originator)
合成路线:The successive...
参考文献标题:C-14-labelling of ipamorelin,a growth hormone secretagogue
文献作者:Muller,L.; et al.
参考来源:J Label Compd Radiopharm 1998,41(12),1093

Isradipine, PN-200110, Lomir, Icaz, DynaCirc, Prescal

伊拉地平Chemical Name: Isopropyl (?-4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylate; (?-4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic...
参考文献标题:Benzoxadiazoles and benzothiadiazoles,their preparation and pharmaceutical compsns.containing them
文献作者:Neumann,P.(Novartis AG)
参考来源:US 4466972