Ivarimod, Ru-18492
伊伐莫德Chemical Name: N-(2-Hydroxyethyl)maleopimarimidyl morpholide; 4-[[(3aR,3bS,5aR,6R,9aR,9bR,11R,11aR)-1,2,3,3a,4,5,,5a,6,7,8,9,9a,9b,10,11,11a-Hexadecahydro-2-(2-hydroxyethyl)-12-isopropyl-6,9a-dimethyl-1,3-dioxo-3b,11-etheno-3bH-naphth[2,1-e]isoindol-6-yl]carbonyl]morpholine
CAS No. 53003-81-9
项目整合开发状态: Biological Testing
项目研究机构: Aventis Pharma (Originator)
合成路线:The reaction of maleopimaric acid (I) with SOCl2 in benzene produces the corresponding acyl chloride (V),which is then condensed with morpholine (A) by means of Et3N in benzene yielding maleopimaryl morpholide (VI).Finally,(VI) is condensed with ethanolamine (B) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:Novel derivatives of maleopimaric acid
文献作者:Taylor,J.B.; et al.(Aventis Pharma SA)
参考来源:DE 2351343; FR 2202691; GB 1417996; JP 49093356; US 3998823
📄 详细内容
合成路线:The reaction of maleopimaric acid (I) with aqueous ammonia and heating at 170 C gives maleopimarimide (II),which by reaction with oxalyl chloride in benzene is converted into the corresponding acyl chloride (III).The reaction of (III) with morpholine (A) in benzene yields maleopimarimidyl morpholide (IV),which is finally condensed with ethanolamine (B) in refluxing methanol.
合成路线:The reaction of maleopimaric acid (I) with SOCl2 in benzene produces the corresponding acyl chloride (V),which is then condensed with morpholine (A) by means of Et3N in benzene yielding maleopimaryl morpholide (VI).Finally,(VI) is condensed with ethanolamine (B) in refluxing ethanol.
参考文献标题:RU 18492
文献作者:Thorpe,P.; Castar,J.
参考来源:Drugs Fut 1977,2(9),623
合成路线:The reaction of maleopimaric acid (I) with aqueous ammonia and heating at 170 C gives maleopimarimide (II),which by reaction with oxalyl chloride in benzene is converted into the corresponding acyl chloride (III).The reaction of (III) with morpholine (A) in benzene yields maleopimarimidyl morpholide (IV),which is finally condensed with ethanolamine (B) in refluxing methanol.
参考文献标题:hepatoprotective agents.II.Maleopimaridyl morpholides
文献作者:Danswan,G.W.; Ramm,P.J.; Matharu,S.; Taylor,J.B.
参考来源:Arzneim-Forsch Drug Res 1976,26(12),2190-92
产品链接: CAS No. 53003-81-9››