Itazogrel, Itazigrel, U-53059, TFT
伊他格雷Chemical Name: 4,5-Bis(4-methoxyphenyl)-2-trifluoromethylthiazole
CAS No. 70529-35-0
项目整合开发状态: Phase II
项目研究机构: Pfizer (Originator)
合成路线:The amonolysis of trifluoroacetonitrile (I) in refluxing liquid ammonia gives trifluoroacetamidine (II),which by reaction with SH2 in ether is converted into trifluorothioacetamide (III).Finally,this compound is cyclized with p-methoxy-alpha-bromo-alpha-(p-methoxyphenyl)acetophenone (IV) in refluxing acetonitrile.
📌 参考资料/链接：
参考文献标题:TFT
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1982,7(5),323
📄 详细内容
合成路线:The amonolysis of trifluoroacetonitrile (I) in refluxing liquid ammonia gives trifluoroacetamidine (II),which by reaction with SH2 in ether is converted into trifluorothioacetamide (III).Finally,this compound is cyclized with p-methoxy-alpha-bromo-alpha-(p-methoxyphenyl)acetophenone (IV) in refluxing acetonitrile.
参考文献标题:
文献作者:Rynbrandt,R.H.; Nishizawa,E.E.
参考来源:US 4168315
产品链接: CAS No. 70529-35-0››