项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Ilomastat, CS-610, GM-6001, Galardin MPI, Galardin

伊洛马司他Chemical Name: 3-(N-Hydroxycarbamoyl)-2(R)-isobutylpropionyl-L-tryptophan methylamide
CAS No. 142880-36-2
项目整合开发状态: Preclinical
项目研究机构: Ligand (Originator), University of Florida (Origin...
参考文献标题:Galardin (TM)
文献作者:Galardy,R.E.
参考来源:Drugs Fut 1993,18(12),1109

Iloperidone, ILO-522, HP-873, Zomaril

伊潘立酮Chemical Name: 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone; 1-[3-(4-Acetyl-2-methoxyphenoxy)propyl]-4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine; 4'...
参考文献标题:N-(Aryloxyalkyl)heteroarylpiperidines and-heteroarylpiperazines,a process for their preparation and their use as medicaments
文献作者:Strupczewski,J.T.; Helsley,G.C.; Chiang,Y.; Bordeau,K.J.(Aventis Pharmaceuticals,Inc.)
参考来源:EP 0402644; JP 1991063263

Ibandronate sodium hydrate, Ibandronic acid monosodium salt monohydrate, Ro-200-5450, R-484, RPR-102289A, BM-21.0955 monosodium salt monohydrate, Boniva, Destara, Bonviva(former Brand Name), Bondronat

伊班膦酸钠伊班膦酸钠伊班膦酸Chemical Name: [1-Hydroxy-3-(N-methyl-N-pentylamino)propylidene]bisphosphonic acid monosodium salt monohydrate
CAS No. 138926-19-9, 138844-81-2 (anhydrous), 114084-78-5 (anhydrous f...
参考文献标题:BM-21.0955,Monosodium Salt,Monohydrate
文献作者:M黨lbauer,R.C.; Bauss,F.
参考来源:Drugs Fut 1994,19(1),13

Ifoxetine sulfate(Rec INNM), CGP-15210G

伊福西汀Chemical Name: (?-Bis[cis-3-hydroxy-4-(2,3-dimethylphenoxy)piperidine] sulfate
CAS No. 66208-11-5 (free base)
项目整合开发状态: Phase II
项目研究机构: Novartis (Originator)
合成路线:Reaction of the N-ca...
参考文献标题:Derivs.of perhydro-aza-heterocycles
文献作者:Paioni,R.(Novartis AG)
参考来源:DE 2738477; US 4160837

Isoxicam, W-9495, Maxicam

伊索昔康Chemical Name: 4-Hydroxy-2-methyl-N-(5-methylisoxazol-3-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
CAS No. 34552-84-6
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合...
参考文献标题:4-Hydroxy-3-(3-isoxazolocarbamyl)-2H-1,2-benzothiazine-1-dioxides and process for their production
文献作者:Zinnes,H.; et al.(Pfizer Inc.)
参考来源:CA 978187; DE 2208351; FR 2128371; GB 1323283; US 3787324; US 3816628; US 3822258

Isomazole hydrochloride, BW-A746C(free base), EMD-41064, BW-746, LY-175326

伊索马唑盐酸盐伊索马唑 Chemical Name: 2-[2-Methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine hydrochloride
CAS No. 87359-33-9, 86315-52-8 (free base), 86315-53-9 (fumarate (1:1))
项目整合开发状态: Phase...
参考文献标题:Pyridine compounds
文献作者:Robertson,D.W.; Hayes,J.S.(Eli Lilly and Company)
参考来源:DD 210273; EP 0093593; GB 2119377; JP 58203991

Ilmofosine, TLP, BM-41440

伊莫福新Chemical Name: 1-Hexadecylmercapto-2-methoxymethyl-rac-glycero-3-phosphocholine
CAS No. 83519-04-4
项目整合开发状态: Phase II
项目研究机构: Roche (Originator)
合成路线:An improved synthesis of ilmofosin...
参考文献标题:Antitumor ether lipids: An improved synthesis of ilmofosine and an enantioselective synthesis of an ilmofosine analog
文献作者:Reddy,K.C.; Byun,H.S.; Bittman,R.
参考来源:Tetrahedron Lett 1994,35(17),2679

Ifetroban, BMS-180291

伊非曲班Chemical Name: (+)-[1(S)-(1alpha,2alpha,3alpha,4alpha)]-3-[2-[3-[4-(Pentylcarbamoyl)oxazol-2-yl]-7-oxabicyclo[2.2.1]hept-2-ylmethyl]phenyl]propanoic acid
CAS No. 143443-90-7
项目整合开发状态: Phase ...
参考文献标题:Thromboxane receptor antagonist BMS-180291: A new pre-clinical lead
文献作者:Misra,R.N.; Brown,B.R.; Sher,P.M.; et al.
参考来源:Bioorg Med Chem Lett 1992,2(1),73

Fopirtoline, D-1126(diHCl)

伏哌托宁Chemical Name: 4-[2-(6-Chloropyridin-2-ylsulfany)]ethyl]morpholine
CAS No. 22514-23-4
项目整合开发状态: Not Determined
项目研究机构:
合成路线:Fopirtoline was synthesized by reaction of 2-morpholinoethy...
参考文献标题:
文献作者:Beschke; et al.
参考来源:DE 2201633

Voglibose, A-71100, AO-128, Basen, Glustat

伏格列波糖Chemical Name: N-[2-Hydroxy-1-(hydroxymethyl)ethyl]valiolamine; 2(S),3(R),4(S),5(S)-Tetrahydroxy-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-5-(hydroxymethyl)-1(S)-cyclohexylamine; 3,4-Dideoxy-4-[[2-hyd...
参考文献标题:N-substituted pseudo-aminosugars,their production and use
文献作者:Horii,S.; Kameda,Y.; Fukase,H.(Takeda Chemical Industries,Ltd.)
参考来源:EP 0056194; US 4701559; US 4777294; US 4803303