Ibandronate sodium hydrate, Ibandronic acid monosodium salt monohydrate, Ro-200-5450, R-484, RPR-102289A, BM-21.0955 monosodium salt monohydrate, Boniva, Destara, Bonviva(former Brand Name), Bondronat

伊班膦酸钠 伊班膦酸钠 伊班膦酸Chemical Name: [1-Hydroxy-3-(N-methyl-N-pentylamino)propylidene]bisphosphonic acid monosodium salt monohydrate
CAS No. 138926-19-9, 138844-81-2 (anhydrous), 114084-78-5 (anhydrous free acid)
项目整合开发状态: Launched-1996
项目研究机构: Chugai (Originator), Roche (Originator), GlaxoSmithKline (Codevelopment)
合成路线:Starting from N-pentylamine (I),the intermediate N-methyl-N-pentylamine (IV) is condensed with methyl methacrylate to give N-methyl-N-pentyl-beta-alanine methyl ester (V).After hydrolysis of the methyl ester (V),the bisphosphonate is produced in the common way using phosphorous oxychloride/phosphorous acid.