合成路线:The reaction of piperidine-4-carboxylic acid (I) with formic acid and acetic anhydride gives 1-formylpiperidine-4-carboxylic acid (II),which is treated with SOCl2 and acetic anhydride to yield the corresponding acyl chloride (III).The Friedel-Crafts condensation of (III) with refluxing 1,3-difluorobenzene (IV) by means of AlCl3 affords 4-(2,4-difluorobenzoyl)-1-formylpiperidine (V),which is treated with hydroxylamine in refluxing ethanol to give the corresponding oxime (VI).The cyclization of (VI) by means of NaH in hot THF/DMF yields 6-fluoro-3-(1-formylpiperidin-4-yl)-1,2-benzisoxazole (VII),which is treated with HCl in refluxing ethanol to afford 6-fluoro-3-(4-piperidyl)-1,2-benzisoxazole (VIII).Finally,this compound is condensed with 4-(3-chloropropoxy)-3-methoxyacetophenone (IX) by means of K2CO3 in hot DMF.The intermediate 4-(3-chloropropoxy)-3-methoxyacetophenone (IX) can be obtained by condensation of 4-hydroxy-3-methoxyacetophenone (IX) with 3-chcloropropyl bromide (X) by means of NaH or K2CO3 in DMF.
参考文献标题:Heteroarylpiperidines,pyrrolidines and piperazines and their use as antipsychotics and analgetics
文献作者:Strupczewski,J.T.; Helsley,G.C.; Chiang,Y.; Bordeau,K.J.; Glamkowski,E.J.(Aventis Pharmaceuticals,Inc.)
参考来源:EP 0542136; EP 0612318; EP 0730452; EP 0957102; EP 0959075; EP 0959076; EP 0963984; JP 1995501055; JP 1997511215; US 5364866; US 5776963; WO 9309102; WO 9511680
合成路线:The reaction of piperidine-4-carboxylic acid (I) with formic acid and acetic anhydride gives 1-formylpiperidine-4-carboxylic acid (II),which is treated with SOCl2 and acetic anhydride to yield the corresponding acyl chloride (III).The Friedel-Crafts condensation of (III) with refluxing 1,3-difluorobenzene (IV) by means of AlCl3 affords 4-(2,4-difluorobenzoyl)-1-formylpiperidine (V),which is treated with hydroxylamine in refluxing ethanol to give the corresponding oxime (VI).The cyclization of (VI) by means of NaH in hot THF/DMF yields 6-fluoro-3-(1-formylpiperidin-4-yl)-1,2-benzisoxazole (VII),which is treated with HCl in refluxing ethanol to afford 6-fluoro-3-(4-piperidyl)-1,2-benzisoxazole (VIII).Finally,this compound is condensed with 4-(3-chloropropoxy)-3-methoxyacetophenone (IX) by means of K2CO3 in hot DMF.The intermediate 4-(3-chloropropoxy)-3-methoxyacetophenone (IX) can be obtained by condensation of 4-hydroxy-3-methoxyacetophenone (IX) with 3-chcloropropyl bromide (X) by means of NaH or K2CO3 in DMF.
参考文献标题:3-(4-Piperidyl)-1,2-benzisoxazoles
文献作者:Strupczewski,J.T.; Allen,R.C.; Gardner,B.A.(Aventis Pharmaceuticals,Inc.)
参考来源:US 4355037
合成路线:The reaction of piperidine-4-carboxylic acid (I) with formic acid and acetic anhydride gives 1-formylpiperidine-4-carboxylic acid (II),which is treated with SOCl2 and acetic anhydride to yield the corresponding acyl chloride (III).The Friedel-Crafts condensation of (III) with refluxing 1,3-difluorobenzene (IV) by means of AlCl3 affords 4-(2,4-difluorobenzoyl)-1-formylpiperidine (V),which is treated with hydroxylamine in refluxing ethanol to give the corresponding oxime (VI).The cyclization of (VI) by means of NaH in hot THF/DMF yields 6-fluoro-3-(1-formylpiperidin-4-yl)-1,2-benzisoxazole (VII),which is treated with HCl in refluxing ethanol to afford 6-fluoro-3-(4-piperidyl)-1,2-benzisoxazole (VIII).Finally,this compound is condensed with 4-(3-chloropropoxy)-3-methoxyacetophenone (IX) by means of K2CO3 in hot DMF.The intermediate 4-(3-chloropropoxy)-3-methoxyacetophenone (IX) can be obtained by condensation of 4-hydroxy-3-methoxyacetophenone (IX) with 3-chcloropropyl bromide (X) by means of NaH or K2CO3 in DMF.
参考文献标题:3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: Antipsychotic profile of iloperidone (HP 873)
文献作者:Strupczewski,J.T.; Bordeau,K.J.; Chiang,Y.; Glamkowski,E.J.; Conway,P.G.; Corbett,R.; Hartman,H.B.; Szewczak,M.R.; Wilmot,C.A.; Helsley,G.C.
参考来源:J Med Chem 1995,38(7),1119-31
合成路线:The reaction of piperidine-4-carboxylic acid (I) with formic acid and acetic anhydride gives 1-formylpiperidine-4-carboxylic acid (II),which is treated with SOCl2 and acetic anhydride to yield the corresponding acyl chloride (III).The Friedel-Crafts condensation of (III) with refluxing 1,3-difluorobenzene (IV) by means of AlCl3 affords 4-(2,4-difluorobenzoyl)-1-formylpiperidine (V),which is treated with hydroxylamine in refluxing ethanol to give the corresponding oxime (VI).The cyclization of (VI) by means of NaH in hot THF/DMF yields 6-fluoro-3-(1-formylpiperidin-4-yl)-1,2-benzisoxazole (VII),which is treated with HCl in refluxing ethanol to afford 6-fluoro-3-(4-piperidyl)-1,2-benzisoxazole (VIII).Finally,this compound is condensed with 4-(3-chloropropoxy)-3-methoxyacetophenone (IX) by means of K2CO3 in hot DMF.The intermediate 4-(3-chloropropoxy)-3-methoxyacetophenone (IX) can be obtained by condensation of 4-hydroxy-3-methoxyacetophenone (IX) with 3-chcloropropyl bromide (X) by means of NaH or K2CO3 in DMF.
参考文献标题:Iloperidone
文献作者:Mucke,H.A.M.; Castar,J.
参考来源:Drugs Fut 2000,25(1),29
产品链接: CAS No. 133454-47-4››