Ecabet sodium, TA-2711E, TA-2711, Gastrom
伊卡倍特钠(1R,4aS,10aR)-7-异丙基-1,4a-二甲基-6-磺基-1,2,3,4,4a,9,10,10a-八氢菲-1-羧酸Chemical Name: 12-Sulfodehydroabietic acid monosodium salt; [1R-(1alpha,4abeta,10aalpha)]-7-Isopropyl-1,4a-dimethyl-6-sulfo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid monosodium salt; 13-Isopropyl-12-sulfopodocarpa-8,11,13-trien-15-oic acid monosodium salt
CAS No. 86408-72-2, 86408-71-1 (diNa salt), 33159-27-2 (free acid)
项目整合开发状态: Launched-1993
项目研究机构: Tanabe Seiyaku (Originator), Tanabe AAI (Licensee)
合成路线:The dehydrogenation of abietic acid (I) over Pd at 250 C gives dehydroabietic acid (II),which is sulfonated with sulfuric acid at -5 C yielding 12-sulfodehydroabietic acid (III).Finally,this compound is neutralized with NaOH in water.
📌 参考资料/链接：
参考文献标题:TA-2711
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(11),966
📄 详细内容
合成路线:The dehydrogenation of abietic acid (I) over Pd at 250 C gives dehydroabietic acid (II),which is sulfonated with sulfuric acid at -5 C yielding 12-sulfodehydroabietic acid (III).Finally,this compound is neutralized with NaOH in water.
参考文献标题:Antiulcer activity of dehydroabietic acid derivati
文献作者:Wada,H.; Kodato,S.-I.; Kawamori,M.; Morikawa,T.; Nakai,H.; Takeda,M.; Saito,S.; Onoda,Y.; Tamaki,H.
参考来源:Chem Pharm Bull 1985,33(4),1472
合成路线:The dehydrogenation of abietic acid (I) over Pd at 250 C gives dehydroabietic acid (II),which is sulfonated with sulfuric acid at -5 C yielding 12-sulfodehydroabietic acid (III).Finally,this compound is neutralized with NaOH in water.
参考文献标题:Substitution reactions of dehydroabietic acid
文献作者:Fieser,L.F.; Campbell,W.P.
参考来源:J Am Chem Soc 1938,602631
产品链接: CAS No. 86408-72-2›› 产品链接: CAS No.33159-27-2››