Isradipine, PN-200110, Lomir, Icaz, DynaCirc, Prescal

伊拉地平Chemical Name: Isopropyl (?-4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylate; (?-4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester; (?-4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl 5-methyl diester
CAS No. 75695-93-1
项目整合开发状态: Launched-1989
项目研究机构: Novartis (Originator), Sankyo (Marketer), Reliant Pharmaceuticals (Licensee)
合成路线:By cyclization of 2,1,3-benzoxadiazole-4-carbaldehyde (I) with isopropyl acetoacetate (II) and methyl 3-aminocrotonate (III) in refluxing ethanol.