Ipamorelin, NSAC, NNC-26-0161

伊帕瑞林Chemical Name: 2-Methyl-alanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenyalanyl-L-lysinamide
CAS No. 170851-70-4
项目整合开发状态: Phase I
项目研究机构: Novo Nordisk (Originator)
合成路线:The successive condensations of fluorenylmethoxycarbonyl-Rink amide resin (I) with Nalpha-FMOC-Nepsilon-Boc-L-lysine (II),FMOC-D-phenylalanine (IV),FMOC-D-2-naphthylalanine (VI),FMOC-Npi-trityl-L-histidine (VIII),and finally 2-(tert-butoxycarbonylamino)isobutyric acid (X),using the solid phase peptide technique synthesis yielded resins (III),(V),(VII),(IX) and finally (XI).This last resin was then treated with trifluoroacetic acid in order to eliminate the Boc protecting groups and the solid phase resin and isolate the target compound.