项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Methyl aminolevulinate, Aminolevulinic acid methyl ester, ALA Me ester, P-1202, Metvix PDT, Metvix

5-氨基-4-氧代戊酸甲酯 5-氨基酮戊酸甲酯盐酸盐 Chemical Name: 5-Amino-4-oxopentanoic acid methyl ester; 5-Aminolevulinic acid methyl ester
CAS No. 33320-16-0, 79416-27-6 (hydrochloride)
项目整合开发状态: Launched-2001
项...
参考文献标题:Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
文献作者:Moan,J.; Steen,H.; Gierskcky,K.E.; Warloe,T.; Bjorseth,A.; Peng,Q.(PhotoCure ASA)
参考来源:US 6034267; WO 9628412

AdThd

5-氨基-5-脱氧胸腺嘧啶脱氧核苷Chemical Name: 5'-Amino-5'-deoxythymidine
CAS No. 25152-20-9, 67883-75-4 (monoacetate salt), 67883-74-3 (monoHCl)
项目整合开发状态: Preclinical
项目研究机构: Research Corporation Technolog...
参考文献标题:AdThd
文献作者:Blancafort,P.; Hopkins,S.J.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(3),179

Freselestat, ONO-PO-736, ONO-6818

5-氨基-N-[1-[[5-(1,1-二甲基乙基)-1,3,4-恶二唑-2-基]羰基]-2-甲基丙基]-6-氧-2-苯基-1(6H)-嘧啶乙酰胺Chemical Name: 2-(5-Amino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-ycarbonyl)-2-methylprop...
参考文献标题:1,3,4-Oxadiazole derivs.and process for producing the same
文献作者:Kojima,T.; Hachiya,K.; Ohmoto,K.(Ono Pharmaceutical Co.,Ltd.)
参考来源:EP 1162199; WO 0055145

Aminolevulinic acid hydrochloride, delta-Aminolevulinic acid hydrochloride, ALA-PDT, ALA HCl, Levulan Kerastick, Levulan

5-氨基乙酰丙酸盐酸盐Chemical Name: 5-Amino-4-oxopentanoic acid hydrochloride; 5-Aminolevulinic acid hydrochloride
CAS No. 5451-09-2, 60556-69-6 ([15N]-labeled), 7729-71-7 ([4-14C]-labeled), 106-60-5 (free b...
参考文献标题:Method of producing delta-aminolevulinic acid hydrochloride
文献作者:Aronova,N.I.; Makhova,N.N.; Zavyalov,S.I.; Volkenshtein,J.B.; Kunitskaya,G.M.
参考来源:US 3846490

新产品编号:19493

5-氯-1-(4-氯苄基)-3-(苯基硫基)-1H-吲哚-2-羧酸Chemical Name: 5-Chloro-1-(4-chlorobenzyl)-3-(phenylsulfanyl)-1H-indole-2-carboxylic acid
CAS No. 118414-59-8
项目整合开发状态: Preclinical
项目研究机构: Merck & Co. (Origi...
参考文献标题:3-Hetero-substd.-N-benzyl-indoles
文献作者:Yamamoto,H.; et al.(Sumitomo Chemical Co.,Ltd.)
参考来源:US 3907812

新产品编号:777271

5-氯-1-甲基-2-(三氟甲基)-1H-苯并[d]咪唑Chemical Name: 5-Chloro-1-methyl-2-(trifluoromethyl)-1H-benzimidazole
CAS No. 30064-10-9
项目整合开发状态: Biological Testing
项目研究机构: Cent. Invest. Estudios Avanzados IPN ...
参考文献标题:Synthesis and biological activity of novel 2-trifluoromethylbenzimidazole derivatives
文献作者:Hernandez,F.; Cedillo,R.; Navarrete,G.; Castillo,R.; Morales,R.; Y閜ez,L.; Tapia,A.
参考来源:219th ACS Natl Meet (March 26 2000,San Francisco) 2000,Abst MEDI 146

Clamikalant sodium, HMR-1098

5-氯-2-甲氧基-N-[2-[4-甲氧基-3-(3-甲基噻哜二磺酰)苯]乙基]苯甲胺钠盐 5-氯-2-甲氧基-N-[2-[4-甲氧基-3-[[[(甲基氨基)硫代甲酰]氨基]磺酰基]苯基]乙基]-苯甲酰胺 Chemical Name: 5-Chloro-2-methoxy-N-[2-[4-methoxy-3-(3-methylthioureidosulfonyl)phenyl]ethyl]benz...
参考文献标题:Substd.benzenesulfonylureas and -thioureas,process for their preparation and their use as pharmaceuticals
文献作者:Englert,H.; Mania,D.; Hartung,J.; G鰃elein,H.; Kaiser,J.; Linz,W.; Wettlaufer,D.(Aventis Pharma Deutschland GmbH)
参考来源:CA 2116165; EP 0612724; JP 1995304728; US 5574069; US 5698596; US 5776980

SB-272183

5-氯-6-(4-甲基哌嗪-1-基)-N-[4-(4-吡啶)萘-1-基]吲哚哚-1-羧酰胺Chemical Name: 5-Chloro-6-(4-methylpiperazin-1-yl)-N-[4-(4-pyridyl)naphthalen-1-yl]indoline-1-carboxamide
CAS No. 216058-27-4
项目整合开发状态: Preclinical 参考文献标题:Indole derivs.having combined 5HT1A,5HT1B and 5HT1D receptor antagonist activity
文献作者:Gaster,L.M.; Rami,H.K.; Wyman,P.A.(SmithKline Beecham plc)
参考来源:EP 0975593; WO 9850358

NBI-27914

5-氯-N-(环丙基甲基)-2-甲基-N-丙基-N'-(2,4,6-三氯苯基)嘧啶-4,6-二胺Chemical Name: N-[5-Chloro-2-methyl-6-(2,4,6-trichlorophenylamino)pyrimidin-4-yl]-N-(cyclopropylmethyl)-N-propylamine
CAS No. 184241-44-9
项目整合开发状态...
参考文献标题:Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists
文献作者:Dagnino,R.jr.; Chen,C.; de Souzza,E.B.; et al.
参考来源:J Med Chem 1996,39(22),4360

Brimonidine tartrate, AGN-190342-LF, UK-14304-18, Alphagan P, Alphagan

5-溴-6-(2-咪唑林-2-乙氨基)喹喲沙林D-酒石酸盐溴莫尼定布林莫尼定酒石酸盐Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline D-tartrate; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine D-tartrate
CAS No. 7...
参考文献标题:Synthesis and characterization of degradation products andmetabolites of brimonidine - A potent alpha2 adrenergic agonist
文献作者:Tang-Liu,D.; Burke,J.; Garst,M.; Harcourt,D.; Acheampong,A.; Breau,A.; Munk,S.A.; Wong,H.; Lai,R.; Wheeler,L.
参考来源:211th ACS Natl Meet (March 24-28,New Orleans) 1996,Abst MEDI 021