项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

FPL-66096(formerly), ARL-66096, AR-C66096

5'-腺苷酸,2-(丙硫代)-,5'-酐与(二氟甲基)双[磷酸]Chemical Name: 5'-O-[[[Difluoro(phosphono)methyl](hydroxy)phosphoryloxy](hydroxy)phosphoryl]-2-(propylsulfanyl)adenosine
CAS No. 145783-24-0, 145782-74-7 (tetrasodiu...
参考文献标题:ATP analogues
文献作者:Ingall,A.H.; Cage,P.A.(Celltech Medeva plc)
参考来源:EP 0508687; US 5654285

ARL-67085, AR-C67085MX(former code)

5'-腺苷酸,2-(丙硫代)-,单酐与(二氯甲基苯)双[磷酸],四钠盐(9CI)Chemical Name: 5'-O-[[[Dichloro(phosphono)methyl](hydroxy)phosphoryloxy](hydroxy)phosphoryl]-2-(propylsulfanyl)adenosine tetrasodium salt; 2-(Propylsulfanyl)-5'...
参考文献标题:Antagonists of the platelet P2T receptor: A novel approach to antithrombotic therapy
文献作者:Ingall,A.H.; Dixon,J.; Bailey,A.; Coombs,M.E.; Cox,D.; McInally,J.I.; Hunt,S.F.; Kindon,N.D.; Teobald,B.J.; Willis,P.A.; Humphries,R.G.; Leff,P.; Clegg,J.A.; Smith,J.A.; Tomlinson,W.
参考来源:J Med Chem 1999,42(2),213

ILX-295501, LY-295501

5-苯呋喃磺酰胺,N-[[(3,4-二氯苯基)氨基]-2,3-二氢-Chemical Name: 1-(3,4-Dichlorophenyl)-3-(2,3-dihydrobenzofuran-5-ylsulfonyl)urea; N1-(3,4-Dichlorophenyl)-N2-(2,3-dihydrobenzofuran-5-ylsulfonyl)urea
CAS No. 15086...
参考文献标题:Synthesis of bicyclic aromatic sulfonic acids,sulfonyl chlorides and sulfonamides
文献作者:Tao,E.V.-P.; Miller,W.D.(Eli Lilly and Company)
参考来源:EP 0583960

AY-31637

5-萘-2-基磺酰基-1,3-噻唑烷-2,4-二酮Chemical Name: 5-(2-Naphthylsulfonyl)-2,4-thiazolidinedione
CAS No. 125518-46-9
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:AY-31,637 may...
参考文献标题:5-[(1- and 2-Naphthalenyl)sulfonyl]-2,4-thiazolidinediones and derivs.Thereof
文献作者:Zask,A.; Jirkovsky,I.(American Home Products Corp.)
参考来源:US 4997948

Liarozole fumarate, R-75251(monohydrochloride), R-85246, Liazal

6-((3-氯苯基)(1H-咪唑-1-基)甲基)-1H-苯并[d]咪唑Chemical Name: (?-5-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-benzimidazole (E)-2-butenedioate (2:3); (?-5-(3-Chloro-alpha-imidazol-1-ylbenzyl)benzimidazole fuma...
参考文献标题:Novel (1H-imidazol-1-ylmethyl) substd.benzimidazole derivs
文献作者:Raeymaekers,A.H.M.; Freyne,E.J.E.; Sanz,G.C.(Janssen Pharmaceutica NV)
参考来源:AU 8778385; EP 0260744; JP 1989085975; US 4859684

Tetomilast, OPC-6535

6-(2-(3,4-二乙氧基苯基)噻唑-4-基)甲酸吡啶Chemical Name: 6-[2-(3,4-Diethoxyphenyl)thiazol-4-yl]pyridine-2-carboxylic acid
CAS No. 145739-56-6
项目整合开发状态: Phase III
项目研究机构: Otsuka (Originator)
合成路线:Bromina...
参考文献标题:Cytokine production inhibitors and adhesion inhibitors
文献作者:Chihiro,M.; Matsuzaki,T.; Nagamoto,T.; Toda,G.; Sueyoshi,S.; Mori,T.; Kitano,K.; Takemura,I.; Yamashita,H.; Kurimura,M.; Tabusa,F.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:JP 1998152437; US 2002013469; US 6583163; WO 9814191

Nanterinone, UK-61260-27(mesylate), UK-61260

6-(2,4-二甲基咪唑-1-基)-8-甲基-1H-喹啉-2-酮 6-(2,4-二甲基咪唑-1-基)-8-甲基-1h-喹啉-2-酮甲烷磺酸 Chemical Name: 6-(2,4-Dimethylimidazol-1-yl)-8-methylquinolin-2(1H)-one
CAS No. 102791-47-9, 102791-74-2 (mesylate salt)
项目整...
参考文献标题:Quinolone inotropic agents
文献作者:Roberts,D.A.; Campbell,S.F.(Pfizer Inc.)
参考来源:AU 8543032; EP 0166533; ES 8608874; ES 8801797; JP 1986000082; US 4728653

CI-1029, PD-178390

6(S)-[2-(4-氨基苯基)乙基]-3-[2-叔丁基-4-(羟甲基甲基)-5-甲基苯基磺酰]-4-羟基-6-异丙基-5,6-二氢-2H-吡喃-2-1Chemical Name: 6(S)-[2-(4-Aminophenyl)ethyl]-3-[2-tert-butyl-4-(hydroxymethyl)-5-methylphenylsulfanyl]-4-hydroxy-6-isopropyl...
参考文献标题:Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices.PD 178390: A lead HIV protease inhibitor
文献作者:Vara Prasad,J.V.N.; Boyer,F.E.; Domagala,J.M.; Ellsworth,E.L.; Gajda,C.; Hamilton,H.W.; Hagen,S.E.; Markoski,L.J.; Steinbaugh,B.A.; Tait,B.D.; Humblet,C.; Lunney,E.A.; Pavlovsky,A.; Rubin,J.R.; Ferguson,D.; Graham,N.; Holler,T.; et al.
参考来源:Bioorg Med Chem 1999,7(12),2775

Anisperimus, LF-15-0195

6-(二氨基亚甲基氨基)己基氨基甲酰甲基N-[4-[[(3R)-3-氨基丁基]氨基]丁基]氨基甲酸酯Chemical Name: N-[4-[3(R)-Aminobutylamino]butyl]carbamic acid N-(6-guanidinohexyl)carbamoylmethyl ester
CAS No. 170368-04-4
项目整合开发状态: Phase I/II...
参考文献标题:Structure - Immunosuppressive activity relationships of new analogues of 15-deoxyspergualin.2.Structural modifications of the spermidine moiety
文献作者:Lebreton,L.; Jost,E.; Carboni,B.; Annat,J.; Vaultier,M.; Dutartre,P.; Renaut,P.
参考来源:J Med Chem 1999,42(23),4749

Sepimostat mesilate, TO-187, FUT-187

6-(氨基亚胺甲基)-2-萘基4-((4,5-二氢-1H-咪唑-2-基)氨基苯甲酸酯二甲烷磺酸盐司匹司他Chemical Name: 4-(4,5-Dihydro-1H-imidazol-2-ylamino)benzoic acid 6-amidinonaphthalen-2-yl ester dimethanesulfonate; 6-[4-(2-Imidazolidinylideneamino...
参考文献标题:Novel amidine cpds
文献作者:Fujii,S.; Okutome,T.; Nakayama,T.; Nunomura,S.; Sudo,K.; Watanabe,S.; Kurumi,M.; Aoyama,T.(Torii Pharmaceutical Co.,Ltd.)
参考来源:AU 8545492; EP 0190356; ES 8607218; US 4777182; US 4820730; WO 8600893