AdThd
5-氨基-5-脱氧胸腺嘧啶脱氧核苷Chemical Name: 5'-Amino-5'-deoxythymidine
CAS No. 25152-20-9, 67883-75-4 (monoacetate salt), 67883-74-3 (monoHCl)
项目整合开发状态: Preclinical
项目研究机构: Research Corporation Technologies (Originator)
合成路线:The reaction of thymidine (I) with tosyl chloride in pyridine gives 5'-O-tosylthymidine (II),which by reaction with lithium azide is converted into 5'-azido-5'-deoxythymidine (III).Finally,this compound is reduced with H2 over PtO2 in ethanol.
📌 参考资料/链接：
参考文献标题:AdThd
文献作者:Blancafort,P.; Hopkins,S.J.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(3),179
📄 详细内容
合成路线:The reaction of thymidine (I) with tosyl chloride in pyridine gives 5'-O-tosylthymidine (II),which by reaction with lithium azide is converted into 5'-azido-5'-deoxythymidine (III).Finally,this compound is reduced with H2 over PtO2 in ethanol.
参考文献标题:Synthesis and biological activity of several amino analogues of thymidine
文献作者:Lin,T.S.; Prusoff,W.H.
参考来源:J Med Chem 1978,21(1),109-112
合成路线:The reaction of thymidine (I) with tosyl chloride in pyridine gives 5'-O-tosylthymidine (II),which by reaction with lithium azide is converted into 5'-azido-5'-deoxythymidine (III).Finally,this compound is reduced with H2 over PtO2 in ethanol.
参考文献标题:Nucleosides.I.5'-Amino-5'-deoxyuridine and 5'-amino-5'-deoxythymidine
文献作者:Urbanski,J.A.; Chua,J.; Tomson,A.J.; Horwitz,J.P.
参考来源:J Org Chem 1962,273045-48
产品链接: CAS No. 25152-20-9››