NBI-27914

5-氯-N-(环丙基甲基)-2-甲基-N-丙基-N'-(2,4,6-三氯苯基)嘧啶-4,6-二胺Chemical Name: N-[5-Chloro-2-methyl-6-(2,4,6-trichlorophenylamino)pyrimidin-4-yl]-N-(cyclopropylmethyl)-N-propylamine
CAS No. 184241-44-9
项目整合开发状态: Preclinical
项目研究机构: Neurocrine Biosciences (Originator)
合成路线:The condensation of 4,6-dichloro-2-methylpyrimidine (I) with 2,4,6-trichloroaniline (II) by means of NaH in THF gives N-(6-chloro-2-methylpyrimidin-4-yl)-N-(2,4,6-trichlorophenyl)amine (III),which is condensed with N-(cyclopropylmethyl)-N-propylamine (IV) by heating at 100-190 C yielding N-(cyclopropylmethyl)-N-[2-methyl-6-(2,4,6-trichlorophenylamino)-pyrimidin-4-yl]-N-propylamine (V).Finally,this compound is chlorinated with N-chlorosuccinimide (NCS) in refluxing chloroform.