其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Piracetam CAS Registry Number: 7491-74-9 吡拉西坦

CAS Name: 2-Oxo-1-pyrrolidineacetamide
Additional Names: 2-pyrrolidoneacetamide; 2-pyrrolidinoneacetamide; 2-ketopyrrolidine-1-ylacetamide; 1-acetamido-2-pyrrolidinoneTrademarks: Avigilen (Riem...
Literature References: Prepn: H. Morren, NL 6509994; eidem, US 3459738 (1966, 1969 both to U.C.B.). Pharmacology: Giurgea et al., Arch. Int. Pharmacodyn. Ther. 166, 238 (1967); Giurgea, Moyersoons, ibid. 188, 401 (1970); Giurgea et al., Psychopharmacologia 20, 160 (1971). Metabolism and biochemical studies: Gobert, J. Pharm. Belg. 27, 281 (1972). Clinical studies: W. J. Oosterveld, Arzneim.-Forsch. 30, 1947 (1980); G. Chouinard et al., Psychopharmacol. Bull. 17, 129 (1981); in dyslexia: M. Di Ianni et al., J. Clin. Psychopharmacol. 5, 272 (1985).

Proquazone CAS Registry Number: 22760-18-5 普罗喹宗

CAS Name: 7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone
Additional Names: 1-isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinoneTrademarks: Biarison (Sandoz-Wander)
Percent Composition:...
Literature References: Prepn: H. Ott, M. Denzer, DE 1805501 corresp to US 3845128 and US 3925548 (1969, 1974 and 1975, all to Sandoz); R. V. Coombs et al., J. Med. Chem. 16, 1237 (1973). Metabolism: M. B. Zucker, Proc. Soc. Exp. Biol. Med. 156, 209 (1977); H. Ott, J. Meier, Scand. J. Rheumatol. Suppl. 21, 12 (1978). Pharmacology: H. U. Gubler, M. Baggiolini, ibid. 8; H. Ott, ibid. 5. Clinical studies: P. Sfikakis, P. Tsachalos, Ther. Umsch. 34, 730 (1977); series of articles in Scand. J. Rheumatol. Suppl. 21, 15-39 (1978). Review of pharmacodynamics, pharmacokinetics and therapeutic efficacy: S. P. Clissold, R. Beresford, Drugs 33, 478-502 (1987).

Glisoxepid CAS Registry Number: 25046-79-1 格列派特

CAS Name: N-[2-[4-[[[[(Hexahydro-1H-azepin-1-yl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-3-isoxazolecarboxamide
Additional Names: 1-(hexahydro-1H-azepin-1-yl)-3-[[p-[2-(5-methyl-3-i...
Literature References: Prepn: H. Plümpe, W. Puls, ZA 6806886; eidem, US 3668215 (1969, 1972 both to Bayer). Pharmacology: Loubatieres et al., C.R. Seances Acad. Sci. Ser. D 271, 1446 (1970); J. Pharmacol. 3, 171, 229 (1972). Toxicity study: Tettenborn, Arzneim.-Forsch. 24, 409 (1974). Series of articles: ibid. 363-452.

Ontianil CAS Registry Number: 35727-72-1 翁硫尼尔

CAS Name: N-(4-Chlorophenyl)-2,6-dioxocyclohexanecarbothioamide
Additional Names: 4'-chloro-2,6-dioxothiocyclohexanecarboxanilide
Percent Composition: C 55.42%, H 4.29%, Cl 12.58%, N 4.97%, ...
Literature References: Prepn: H. Ruschig et al., DE 2039466; eidem, US 3746765 (1972, 1973 both to Hoechst); of sodium, potassium, calcium salts: eidem, DE 2317579 (1974 to Hoechst), C.A. 82, 64537f (1975).

Carticaine CAS Registry Number: 23964-58-1 阿替卡因

CAS Name: 4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester
Additional Names: 3-propylamino-a-propionylamino-2-carbomethoxy-4-methylthiophene; methyl 4-met...
Literature References: Prepn: H. Ruschig et al., ZA 6804265; eidem, US 3855243 (1969, 1974 both to Farbwerke Hoechst). Pharmacological studies: R. Muschaweck, R. Rippel, Prakt. Anaesth. 9, 135 (1974); H. Hofer et al., ibid. 157; A. Den Hertog, Eur. J. Pharmacol. 26, 175 (1974). Toxicity studies: C. Baeder et al., Prakt. Anaesth. 9, 147 (1974). Mechanism of action: U. Borchard, H. Drouin, Eur. J. Pharmacol. 62, 73 (1980). Review: H. Schneider, Schweiz. Monatsschr. Zahnheilkd. 86, 1188-1194 (1976).

Bacitracin Zinc CAS Registry Number: 1405-89-6 杆菌肽锌

Additional Names: Zinc bacitracin
Trademarks: Albac (Alpharma); Baciferm (Roche)
Literature References: Prepn: H. S. Anker et al., J. Bacteriol. 55, 249 (1948). Review of properties and formulatory characteristics: H. M. Gross, Drug Cosmet. Ind. 75, 612 (1954); idem et al., J. Am. Pharm. Assoc. Sci. Ed. 45, 447 (1956). Solubility data: P. J. Weiss et al., Antibiot. Chemother. 7, 374 (1957). ELISA determn in animal feed: C. Williams et al., Analyst 119, 427 (1994). Field trials as performance enhancer in pigs: S. C. Kyriakis et al., Vet. Rec. 138, 489 (1996); in chickens: G. Huyghebaert, G. De Groote, Poult. Sci. 76, 849 (1997). Clinical trial in giardiasis: B. J. Andrews et al., Am. J. Trop. Med. Hyg. 52, 318 (1995); in prevention of wound infection: D. J. Dire et al., Acad. Emerg. Med. 2, 4 (1995).

Spizofurone CAS Registry Number: 72492-12-7 螺佐呋酮

CAS Name: 5-Acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-oneTrademarks: Maon (Takeda)
Percent Composition: C 71.28%, H 4.98%, O 23.74%
Literature References: Prepn: H. Sugihara et al., EP 3084; eidem, US 4284644 (1979, 1981 both to Takeda); M. Kawada et al., Chem. Pharm. Bull. 32, 3532 (1984). One step synthesis: M. Watanabe et al., ibid. 3373. Anti-ulcerative effect in animals: N. Inatomi et al., Arzneim.-Forsch. 35, 1553 (1985). Cytoprotective effects on rat gastric mucosa: eidem, Eur. J. Pharmacol. 112, 81 (1985). Stimulation of endogenous prostaglandin synthesis in vitro: I. Inada et al., ibid. 124, 149 (1986).

N,N-Dimethylglycine CAS Registry Number: 1118-68-9 N,N-二甲基甘氨酸

Additional Names: (Dimethylamino)acetic acid; N-methylsarcosine; DMG
Percent Composition: C 46.59%, H 8.80%, N 13.58%, O 31.03%
Literature References: Prepn: H. T. Clarke et al., J. Am. Chem. Soc. 55, 4571 (1933); D. E. Pearson, J. D. Bruton, ibid. 73, 864 (1951). Mutagenicity study: N. Colman et al., Proc. Soc. Exp. Biol. Med. 164, 9 (1980). Constituent of some products sold in the U.S. as "pangamic acid".

Epichlorohydrin CAS Registry Number: 106-89-8 环氧氯丙烷

CAS Name: Chloromethyloxirane
Additional Names: dl-a-epichlorohydrin; 1-chloro-2,3-epoxypropane; g-chloropropylene oxide
Percent Composition: C 38.95%, H 5.45%, Cl 38.32%, O 17.29%
Literature References: Prepn: H. T. Clarke, W. W. Hartman, Org. Synth. coll. vol. I, 233 (2nd ed., 1941); G. Braun, ibid. coll. vol. II, 256 (1943). Manuf: Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 335-338. Toxicity data: H. F. Smyth, C. P. Carpenter, J. Ind. Hyg. Toxicol. 30, 63 (1948).

Heptaminol CAS Registry Number: 372-66-7 6-氨基-2-甲基-2-庚醇

CAS Name: 6-Amino-2-methyl-2-heptanol
Additional Names: 2-methyl-6-amino-2-heptanol; 6-methyl-2-amino-6-heptanol
Percent Composition: C 66.16%, H 13.19%, N 9.64%, O 11.02%
Literature References: Prepn: H. T. F. Givens, R. M. Herbst, US 2457656 (1948 to Bilhuber); of hydrochloride: J. Doeuvre, J. Poizat, Compt. Rend. 224, 286 (1947). Pharmacokinetics and metabolism: F. Chanoine et al., Arzneim.-Forsch. 31, 1430 (1981). HPLC determn in biological fluids: R. R. Brodie et al., J. Chromatogr. 274, 179 (1983). Clinical trial in hypotension: D. Milon et al., Fundam. Clin. Pharmacol. 4, 695 (1990). Review of mode of action: B. Pourrias Ann. Pharm. Fr. 49, 127-138 (1991).