其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Piperonyl Butoxide CAS Registry Number: 51-03-6 胡椒基丁醚

CAS Name: 5-[[2-(2-Butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole
Additional Names: a-[2-(2-butoxyethoxy)ethoxy]-4,5-methylenedioxy-2-propyltoluene; [3,4-(methylenedioxy)-6-propylbenzyl]...
Literature References: Prepn: H. Wachs, US 2485681; US 2550737 (1949, 1951 both to U.S. Industrial Chemicals); idem, Science 105, 530 (1947). Toxicity: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969). Review of carcinogenic risk: IARC Monographs 30, 183-195 (1983).

Nioxime CAS Registry Number: 492-99-9 1,2-环己二酮二肟

CAS Name: 1,2-Cyclohexanedione dioxime
Percent Composition: C 50.69%, H 7.09%, N 19.71%, O 22.51%
Literature References: Prepn: Hach et al., Org. Synth. 32, 35 (1952); Boyer, Ellzey, J. Am. Chem. Soc. 82, 2525 (1960); Borger et al., Bull. Soc. Chim. Belg. 73, 73 (1964); Arthur, FR 1339224 (1963 to du Pont).

Chlorobenzilate CAS Registry Number: 510-15-6 乙酯杀螨醇

CAS Name: 4-Chloro-a-(4-chlorophenyl)-a-hydroxybenzeneacetic acid ethyl ester
Additional Names: 4,4'-dichlorobenzilic acid ethyl ester; ethyl 4,4'-dichlorobenzilate; ethyl 2-hydroxy-2,2-bis(4-c...
Literature References: Prepn: Häfliger, US 2745780 (1956 to Geigy); GB 831421 (1960 to Metal Thermit). Toxicity study: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969). Review of carcinogenic risk: IARC Monographs 30, 73-85 (1983).

Oxyphenbutazone CAS Registry Number: 129-20-4 羟基保泰松

CAS Name: 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
Additional Names: 4-butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione; 1-phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-but...
Literature References: Prepn: Hafliger, US 2745783 (1956 to Geigy); Pfister, Hafliger, Helv. Chim. Acta 40, 395 (1957).

Asaprol CAS Registry Number: 516-18-7

CAS Name: 2-Hydroxy-1-naphthalenesulfonic acid calcium salt
Additional Names: calcium 2-hydroxy-1-naphthalenesulfonate; calcium b-naphthol-a-monosulfonate; calcium 2-naphthol-1-sulfonate; 2-nap...
Literature References: Prepn: Hagers Handb. Pharm. Praxis Band 2, 204 (Berlin, 1930).

Bismuth Iodosubgallate CAS Registry Number: 138-58-9 没食子酸铋碘

CAS Name: Hydroxyiodo[(3,4,5-trihydroxybenzoyl)oxy]bismuthine
Additional Names: (gallato)hydroxyiodobismuth; (galloyloxy)hydroxyiodobismuthine; bismuth oxyiodogallate
Trademarks: Airoform; A...
Literature References: Prepn: Hagers Handb. Pharm. Praxis Band I, 1565 (Berlin, 1930).

Bismuth Valerate, Basic CAS Registry Number: 5798-47-0 戊酸氧代铋基酯

CAS Name: Valeric acid bismuth basic salt
Additional Names: basic bismuth valerate; bismuth oxide n-valerate; bismuth valerate oxide; bismuth valerianate; bismuthyl valerate
Percent Composit...
Literature References: Prepn: Hagers Handb. Pharm. Praxis Band I, 687 (Berlin, 1930); Aurivillius, Acta Chem. Scand. 9, 1213 (1955). Crystal structure: Aurivillius, loc. cit.

Ammonium Valerate CAS Registry Number: 42739-38-8 纈草酸銨

CAS Name: Pentanoic acid ammonium salt
Additional Names: valeric acid ammonium salt; ammonium valerianate
Percent Composition: C 50.40%, H 11.00%, N 11.75%, O 26.85%
Literature References: Prepn: Hagers Handb. Pharm. Praxis Vol. II (Springer-Verlag, Berlin, 1969) p 1060; Zuffanti, J. Am. Chem. Soc. 63, 3123 (1941).

Metharbital CAS Registry Number: 50-11-3 美沙比妥

CAS Name: 5,5-Diethyl-1-methyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5,5-diethyl-1-methylbarbituric acid
Trademarks: Gemonil (Abbott)
Percent Composition: C 54.53%, H 7.12%, ...
Literature References: Prepn: Halpern, Jones, J. Am. Pharm. Assoc. 38, 352 (1949); Snyder, Link, J. Am. Chem. Soc. 75, 1881 (1953).

Diphetarsone CAS Registry Number: 515-76-4

CAS Name: [1,2-Ethanediylbis(imino-4,1-phenylene)]bis[arsonic acid] disodium salt
Additional Names: N,N'-ethylenediarsanilic acid disodium salt; bis[p-arsonophenylamino]-1,2-ethane disodium; N,...
Literature References: Prepn: Hamilton, J. Am. Chem. Soc. 45, 2751 (1923).