其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Penfluridol CAS Registry Number: 26864-56-2 五氟利多

CAS Name: 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol
Additional Names: 1-[4,4-bis(p-fluorophenyl)butyl]-4-(4-chloro-a,a,a-trifluoro-m-tolyl)-4-piperid...
Literature References: Prepn: H. K. F. Hermans, C. J. E. Niemegeers, DE 2040231; eidem, US 3575990 (both 1971 to Janssen); Sindelár et al., Collect. Czech. Chem. Commun. 38, 3879 (1973). Pharmacology and toxicology: Janssen et al., Eur. J. Pharmacol. 11, 139 (1970). Crystal structure: Koch, Acta Crystallogr. 29B, 1538 (1973).

Dimethylolpropionic Acid CAS Registry Number: 4767-03-7 二羟甲基丙酸

CAS Name: 3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid
Additional Names: 2,2-bis(hydroxymethyl)propionic acid; dihydroxypivalic acid
Trademarks: DMPA (Geo)
Percent Composition: C 44...
Literature References: Prepn: H. Koch, T. Zerner, Monatsh. Chem. 22, 447, 450 (1891); K. E. Wilzbach et al., J. Am. Chem. Soc. 70, 4069 (1948); R. Riemschneider et al., Monatsh. Chem. 88, 1099 (1957); H. Vieregge, J. F. Arens, Rec. Trav. Chim. 78, 921 (1959).

Febantel CAS Registry Number: 58306-30-2 非班太尔

CAS Name: [[2-[(Methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]biscarbamic acid dimethyl ester
Additional Names: dimethyl [[2-(2-methoxyacetamido)-4-(phenylthio)phenyl]imidocarbonyl]di...
Literature References: Prepn: H. Koelling et al., DE 2423679; eidem, US 3993682 (1975, 1976 both to Bayer). Anthelmintic efficacy: H. Wollweber et al., Arzneim.-Forsch. 28, 2193 (1977); H. Thomas, Res. Vet. Sci. 25, 290 (1978). Safety evaluation in horses: J. A. Shmidl, Vet. Med. Small Anim. Clin. 73, 775 (1978).

Isothipendyl CAS Registry Number: 482-15-5 氮异丙嗪

CAS Name: N,N,a-Trimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-ethanamine
Additional Names: 10-(2-dimethylamino-2-methylethyl)-10H-pyrido[3,2-b][1,4]benzothiazine; 10-(2-dimethylaminopropyl)-...
Literature References: Prepn: H. L. Yale, F. Sowinski, J. Am. Chem. Soc. 80, 1651 (1958). Pharmacology: A. von Schlichtegroll, Arzneim.-Forsch. 8, 489 (1958). Clinical evaluation: N. W. Klehr et al., Therapiewoche 34, 6050 (1984); E. Milsmann, P. Rohdewald, Dermatologica 170, 230 (1985). Spectroscopic determn: M. H. Abdel-Hay et al., J. Pharm. Belg. 45, 259 (1990). HPLC determn: A. Turcant et al., Clin. Chem. 37, 1210 (1991).

Fluphenazine CAS Registry Number: 69-23-8 氟奋乃静

CAS Name: 4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol
Additional Names: 1-(2-hydroxyethyl)-4-[3-(trifluoromethyl-10-phenothiazinyl)propyl]piperazine; 10-[3'-[4'...
Literature References: Prepn: H. L. Yale, F. Sowinski, J. Am. Chem. Soc. 82, 2039 (1960); GB 829246; G. E. Ullyot, US 3058979 (1960, 1962 both to SKF); GB 833474 (1960 to Scherico), C.A. 54, 21143e (1960); E. L. Anderson et al., Arzneim.-Forsch. 12, 937 (1962); H. L. Yale, R. C. Merrill, US 3194733 (1965 to Olin Mathieson). Metabolism: J. Dreyfuss, A. J. Cohen, J. Pharm. Sci. 60, 826 (1971). Comprehensive description of the enanthate ester: K. Florey, Anal. Profiles Drug Subs. 2, 245-262 (1973); of the dihydrochloride: idem, ibid. 263-294; of the decanoate ester: G. Clarke, ibid. 9, 275-294 (1980).

Minaprine CAS Registry Number: 25905-77-5 米那卜林盐酸盐

CAS Name: N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
Additional Names: 4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]morpholine
Percent Composition: C 68.43%, H 7.43%, N...
Literature References: Prepn: H. Laborit, DE 2229215; idem, US 4169158 (1973, 1979 to Centre Etudes Exper. Clin. Physio-Biologie); C.-G. Wermuth, A. Exinger, Agressologie 13, 285 (1972). Pharmacology: H. Laborit et al., ibid. 291. Metabolism of 14C-minaprine: A. G. Rico et al., J. Pharmacol. 9, 170 (1978). Pharmacokinetics: J. P. Jeanniot et al., ibid. 169. Clinical evaluation: A. Garcia-Maffla, M. H. de Garcia, Pharmatherapeutica 2, 265 (1979). Pharmacological evaluation in depression: K. Bizière et al., Arzneim.-Forsch. 32, 824 (1982). Toxicologic study: A. G. Mazure et al., Agressologie 13, 319 (1972).

Fenbendazole CAS Registry Number: 43210-67-9 芬苯达唑

CAS Name: [5-(Phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester
Additional Names: 5-(phenylthio)-2-benzimidazolecarbamic acid methyl ester; methyl 5-(phenylthio)-2-benzimidazolecarbam...
Literature References: Prepn: H. Loewe et al., DE 2164690; eidem, US 3954791 (1973, 1976 both to Hoechst); C. Baeder et al., Experientia 30, 753 (1974). Efficacy vs gastrointestinal nematodes in swine: Enigk et al., Dtsch. Tieraerztl. Wochenschr. 81, 177 (1974).

Bromacil CAS Registry Number: 314-40-9 乙腈中除草定

CAS Name: 5-Bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione
Additional Names: 5-bromo-3-sec-butyl-6-methyluracil; 5-bromo-6-methyl-3-(1-methylpropyl)uracilTrademarks: Hyvar (DuPont...
Literature References: Prepn: H. M. Loux, US 3235357 (1966 to du Pont). Mode of action: C. E. Hoffman, Pestic. Chem., Proc. 2nd Int. Congr. Pestic. 5, A. S. Tahori, Ed, (Gordon and Breach Science Publishers, New York, 1972) pp 65-85. Toxicology: H. Sherman, A. M. Kaplan, Toxicol. Appl. Pharmacol. 34, 189 (1975). Review: Pease, Deye, Anal. Methods Pestic. Plant Growth Regul. Food Addit. 5, 335 (1967).

Sulfisoxazole CAS Registry Number: 127-69-5 磺胺二甲异唑

CAS Name: 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide
Additional Names: N1-(3,4-dimethyl-5-isoxazolyl)sulfanilamide; 3,4-dimethyl-5-sulfanilamidoisoxazole; 5-(4-aminophenylsulfonami...
Literature References: Prepn: H. M. Wuest, M. Hoffer, US 2430094 (1947 to Hoffmann-La Roche). Toxicity study: Seki et al., Arzneim.-Forsch. 15, 1441 (1965). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 487-506 (1973). HPLC determn in biological fluids: D. Jung, S. Oie, Clin. Chem. 26, 51 (1980). Clinical trial in otitis media: P. A. M. Bernard et al., Pediatrics 88, 215 (1991).

Dixyrazine CAS Registry Number: 2470-73-7 地西拉嗪

CAS Name: 2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]ethanol
Additional Names: 10-[2-methyl-3-(4-hydroxyethoxyethyl-1-piperazinyl)propyl]phenothiazine; 1-[2-(2-hyd...
Literature References: Prepn: H. Morren, GB 861420 (1961). Partition properties: B.-A. Persson, Acta Pharm. Suec. 5, 335 (1968). GC-MS determn in blood: G. Brante et al., Eur. J. Clin. Pharmacol. 20, 307 (1981). Clinical pharmacokinetics: H. Liedholm et al., Drug-Nutr. Interact. 3, 87 (1985). Clinical trial in postoperative nausea and vomiting: E. Kokinsky et al., Acta Anaesthesiol. Scand. 43, 191 (1999); A. Johansson et al., ibid. 44, 1093 (2000); as topical anesthetic for cataract surgery: E. Monestam et al., J. Cataract Refract. Surg. 27, 445 (2001). Review of clinical chemistry and early clinical studies: T. Fokstuen, Int. J. Neuropsychiat. 340, 294-299 (1965).