其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Naepaine CAS Registry Number: 2188-67-2 2-(戊基氨基)乙基4-氨基苯甲酸酯

CAS Name: 2-(Pentylamino)ethanol 4-aminobenzoate (ester)
Additional Names: p-aminobenzoic acid 2-n-pentylaminoethyl ester; p-aminobenzoic acid 2-n-amylaminoethyl ester; 2-n-amylaminoethyl p-ami...
Literature References: Prepn: Goldberg, Whitmore, J. Am. Chem. Soc. 59, 2280 (1937). Prepn of dimorphic cryst forms: Kreider, Menotti, ibid. 64, 1227 (1942).

Phenamet CAS Registry Number: 3819-34-9

CAS Name: N-[[4-[Bis(2-chloroethyl)amino]phenyl]acetyl]-L-methionine ethyl ester
Percent Composition: C 52.41%, H 6.48%, Cl 16.28%, N 6.43%, O 11.02%, S 7.36%
Literature References: Prepn: Golubeva et al., Dokl. Akad. Nauk SSSR 119, 83 (1958); Knunyants et al., ibid. 132, 836 (1960).

Myrtecaine CAS Registry Number: 7712-50-7 麦替卡因

CAS Name: 2-[2-(6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethoxy]-N,N-diethylethanamine
Additional Names: 2-[2-(6,6-dimethyl-2-norpinen-2-yl)ethoxy]triethylamine; 2-homomyrtenyloxy-1-(diethylami...
Literature References: Prepn: Goudin, GB 861900 (1961).

N-(Hydroxymethyl)nicotinamide CAS Registry Number: 3569-99-1 N-羟甲基烟酰胺

CAS Name: N-(Hydroxymethyl)-3-pyridinecarboxamide
Additional Names: 3-pyridinecarboxylic acid hydroxymethylamide; pyridine-3-carboxylic acid N-methylolamide
Trademarks: Bilamid(e) (Cilag-Che...
Literature References: Prepn: Graf, J. Prakt. Chem. 138, 292 (1933); Chechelska, Urbanski, Rocz. Chem. 27, 396 (1953), C.A. 49, 1033f (1955).

Etoglucid CAS Registry Number: 1954-28-5 依托格鲁

CAS Name: 2,2'-(2,5,8,11-Tetraoxadodecane-1,12-diyl)bisoxirane
Additional Names: 1,2:15,16-diepoxy-4,7,10,13-tetraoxahexadecane; 1,2-bis[2-(2,3-epoxypropoxy)ethoxy]ethane; triethylene glycol di...
Literature References: Prepn: Greenshields et al., GB 901876 (1962 to ICI); Blyakhman, Zh. Org. Khim. 3, 1423 (1967), C.A. 68, 59384k (1968); X.-P. Gu et al., Synthesis 1985, 649. Pharmacology and metabolism: Duncan, Snow, Biochem. J. 82, 8P (1962); James, Solheim, Xenobiotica 1, 43 (1971). Clinical evaluation in bladder tumors: M. R. G. Robinson et al., J. Urol. 118, 972 (1977); J. Flamm, F. Grof, Urologe B27, 26 (1987).

Benzophenone-6 CAS Registry Number: 131-54-4 2,2'-二羟基-4,4'-二甲氧基二苯甲酮

CAS Name: Bis(2-hydroxy-4-methoxyphenyl)methanone
Additional Names: 2,2'-dihydroxy-4,4'-dimethoxybenzophenone
Trademarks: Uvinul D49 (BASF)
Percent Composition: C 65.69%, H 5.14%, O 29.17...
Literature References: Prepn: Grover et al., J. Chem. Soc. 1955, 3982; Hardy, Forster, US 2773903 (1956 to Am. Cyanamid); Dayan, Roberts; Hahn, Stanley, US 2853522 and US 2853523 (both 1958 to Gen. Aniline); Hosler, Storfer, US 2928878 (1960 to Am. Cyanamid).

Sodium Hexachloroplatinate(IV) CAS Registry Number: 16923-58-3 六氯代铂酸(2-)二钠盐

CAS Name: Disodium hexachloroplatinate(2-)
Additional Names: sodium platinichloride; sodium chloroplatinate
Percent Composition: Cl 46.88%, Na 10.13%, Pt 42.99%
Literature References: Prepn: Grube in Handbook of Preparative Inorganic Chemistry vol. 2, G. Brauer, Ed. (Academic Press, New York, 2nd ed., 1965) pp 1571-1572; Cox, Peters, Inorg. Synth. 13, 173 (1971).

Phenprocoumon CAS Registry Number: 435-97-2 苯丙香豆素

CAS Name: 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one
Additional Names: 3-(a-ethylbenzyl)-4-hydroxycoumarin; 3-(1-phenylpropyl)-4-hydroxycoumarin
Trademarks: Falithrom (Hexal); Marcou...
Literature References: Prepn: Grüssner, Balthasar, US 2723276 (1955 to Hoffmann-La Roche); Junek, Ziegler, Monatsh. Chem. 87, 218 (1956); Schroeder, Link, J. Am. Chem. Soc. 79, 3291 (1957); US 2872457 (1959 to Wisconsin Alumni Res. Found.); GB 805748 (1958 to Geigy); L. R. Pohl, J. Med. Chem. 18, 513 (1975). Resolution: Preis et al., US 3239529 (1966 to Wisconsin Alumni Res. Found.). Conformation in soln: E. J. Valente et al., J. Med. Chem. 21, 141, 231 (1978).

Cacodylic Acid CAS Registry Number: 75-60-5 卡可基酸

CAS Name: Dimethylarsinic acid
Additional Names: hydroxydimethylarsine oxide
Trademarks: Phytar (Monterey)
Percent Composition: C 17.41%, H 5.11%, As 54.29%, O 23.19%
Literature References: Prepn: Guinot, J. Pharm. Chim. 27, 55 (1923), C.A. 17, 21038 (1923); Inverni, Boll. Chim. Farm. 62, 129 (1923), C.A. 17, 24137 (1923); Challenger, Ellis, J. Chem. Soc. 1935, 396; Fioretti, Portelli, Ann. Chim. (Rome) 53, 1869 (1963), C.A. 60, 10712c (l964). Use as herbicide: Sprague, US 3056668 (1962 to Ansul). Toxicity study: G. W. Bailey, J. L. White, Residue Rev. 10, 97 (1965). Review of toxicology and human exposure: Toxicological Profile for Arsenic (PB2000-108021, 2000) 468 pp.

Bismuth Sodium Iodide CAS Registry Number: 53778-50-0

CAS Name: Disodium pentaiodobismuthate(2-)
Additional Names: sodium pentaiodobismuthate(III); sodium bismuth iodide; sodium iodobismuthite
Trademarks: Aniobi; Bismjol
Percent Composition:...
Literature References: Prepn: Gurchot et al., J. Pharmacol. 45, 427 (1932).