其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Sulfaproxyline CAS Registry Number: 116-42-7 磺胺普罗林

CAS Name: p-Isopropoxy-N-sulfanilylbenzamide
Additional Names: N1-(p-isopropoxybenzoyl)sulfanilamide; N1-(4-isopropoxybenzoyl)-p-aminobenzenesulfonamide; sulphaproxyline
Percent Composition:...
Literature References: Prepn: Gysin, US 2503820 (1950 to Geigy).

Sulfoxone Sodium CAS Registry Number: 144-75-2 阿地砜钠

CAS Name: Disodium[sulfonylbis(p-phenylenimino)]dimethanesulfinate
Additional Names: 4,4'-diaminodiphenylsulfone disodium formaldehyde sulfoxylate; disodium formaldehydesulfoxylate-diaminodiphe...
Literature References: Prepn: H. Bauer, J. Am. Chem. Soc. 61, 617 (1939); S. M. Rosenthal, H. Bauer, US 2234981 (1941); G. W. Raiziss et al., J. Am. Pharm. Assoc. 33, 43 (1944); US 2256575 (1941). Therapeutic use in dermatitis herpetiformis: T. Cornbleet, Arch. Dermatol. Syphilol. 64, 684 (1951); S. I. Katz, Arch. Dermatol. 118, 809 (1982); in leprosy: J. H. Peters et al., Lepr. Rev. 46, 171 (1975). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. 19, 553-573 (1990).

Glibornuride CAS Registry Number: 26944-48-9 格列波脲

CAS Name: [1S-(endo,endo)]-N-[[(3-Hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl)amino]carbonyl]-4-methylbenzenesulfonamide
Additional Names: (1R,2R,3S,4S)-1-(2-hydroxy-3-bornyl)-3-(p-tolylsulf...
Literature References: Prepn: H. Bretschneider et al., Monatsh. Chem. 100, 2133 (1969). See also: eidem, ZA 6706161; eidem, US 3770761; eidem, ZA 6902395; eidem, US 3654357 (1968, 1973, 1969, 1972, all to Hoffmann-La Roche). Comprehensive review of pharmacology: Arzneim.-Forsch. 22, 2153-2222 (1972).

Phentydrone CAS Registry Number: 634-19-5 1,2,3,4-四氢-9-芴酮

CAS Name: 1,2,3,4-Tetrahydro-9-fluorenone
Additional Names: THF
Percent Composition: C 84.75%, H 6.57%, O 8.68%
Literature References: Prepn: H. C. Beyerman, W. L. C. Veer, US 2692898 (1954 to Organon); House et al., J. Am. Chem. Soc. 82, 1457 (1960).

Oxamniquine CAS Registry Number: 21738-42-1 硝羟四氢喹啉胺

CAS Name: 1,2,3,4-Tetrahydro-2-[[(1-methylethyl)amino]methyl]-7-nitro-6-quinolinemethanol
Additional Names: 1,2,3,4-tetrahydro-2-[(isopropylamino)methyl]-7-nitro-6-quinolinemethanol; 6-hydroxym...
Literature References: Prepn: H. C. Richards, ZA 6803636; idem, US 3821228 (1967, 1974 both to Pfizer). Discovery of schistosomicidal activity: H. C. Richards, R. Foster, Nature 222, 581 (1969). Metabolism: N. M. Woolhouse, B. Kaye, Parasitology 15, 111 (1977). Genetic activity: T. M. Ong, Mutat. Res. 55, 43 (1978). In vitro activity: C. J. Chavasse et al., Ann. Trop. Med. Parasitol. 72, 293 (1978). Mutagenicity study: R. P. Batzinger, E. Bueding, J. Pharmacol. Exp. Ther. 200, 1 (1977). Pharmacology: R. Foster, Rev. Inst. Med. Trop. Sao Paulo 15, Suppl. 1, 189 (1973), C.A. 83, 188417g (1975). Clinical study: R. J. Pitchford, M. Lewis, S. Afr. Med. J. 53, 677 (1978). HPLC determn in biological fluids: H. W. Jun, M. A. Radwan, Anal. Lett. 18, 1345 (1985). Comprehensive description: I. Ahmad, et al., Anal. Profiles Drug Subs. 20, 601-625 (1991).

Octogen CAS Registry Number: 2691-41-0 环四亚甲基四硝基胺

CAS Name: Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine
Additional Names: 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane; cyclotetramethylene tetranitramine; HMX
Percent Composition: C 16....
Literature References: Prepn: H. Fischer, Ber. 82, 192 (1949); A. F. McKay et al., Can. J. Res. 27, 462 (1949). Determn in explosives by infrared: W. Selig, U.S. Atomic Energy Commission UCRL-7873 (part II), 29 (1965); by HPLC: P. Vouros et al., Anal. Chem. 49, 1039 (1977). Mass spec: E. P. Burrows, Org. Mass Spectrom. 26, 1027 (1991). Thermal analysis of phases using x-ray diffraction: M. Herrmann et al., Z. Kristallogr. 204, 121 (1993). 14N-NMR: M. Kony et al., J. Org. Chem. 59, 5623 (1994). Review of syntheses and properties: B. Singh et al., Def. Sci. J. 28, 41-50 (1978); of thermal behavior: T. L. Boggs, Prog. Astronaut. Aeronaut. 90, 121-175 (1984). Review of toxicology and human exposure: Toxicological Profile for HMX (PB98-101058, 1997) 130 pp.

Carbetapentane CAS Registry Number: 77-23-6 枸橼酸喷托维林

CAS Name: 1-Phenylcyclopentanecarboxylic acid 2-(2-diethylaminoethoxy)ethyl ester
Additional Names: 2-(diethylaminoethoxy)ethyl 1-phenyl-1-cyclopentanecarboxylate; 2-(diethylaminoethoxy)ethyl 1...
Literature References: Prepn: H. G. Morren, GB 753779; idem, US 2842585 (1956, 1958 both to Union Chimique Belge). Antispasmodic activity: D. Wellens, Arzneim.-Forsch. 17, 495 (1967). Clinical effect on lung function: E. Krieger, ibid. 22, 389 (1972).

Trimazosin CAS Registry Number: 35795-16-5 三甲哌唑嗪

CAS Name: 4-(4-Amino-6,7,8-trimethoxy-2-quinazolinyl)-1-piperazinecarboxylic acid 2-hydroxy-2-methylpropyl ester
Percent Composition: C 55.16%, H 6.71%, N 16.08%, O 22.04%
Literature References: Prepn: H. J. Hess, DE 2120495 corresp to US 3669968 (1971, 1972 both to Pfizer). Pharmacological study in rats: J. P. Buyniski et al., Clin. Exp. Hypertens. 2, 1039 (1980), C.A. 94, 76779x (1981). Cardiocirculatory effects in congestive heart failure: N. A. Awan et al., Am. J. Cardiol. 44, 126 (1979). Long-term therapeutic use: K. T. Weber et al., N. Engl. J. Med. 303, 242 (1980).

Flurandrenolide CAS Registry Number: 1524-88-5 氟氢缩松

CAS Name: (6a,11b,16a)-6-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
Additional Names: 6a-fluoro-11b,16a,17,21-tetrahydroxypregn-4-ene-3,20-dione cyclic 16...
Literature References: Prepn: H. J. Ringold et al., DE 1131213; eidem, US 3126375 (1962, 1964 both to Syntex). HPLC determn in pharmaceutical cream: R. Pearlman et al., Int. J. Pharm. 18, 53 (1984); in urine: E. Neufeld et al., J. Chromatogr. B 718, 273 (1998). Clinical trial in psoriasis: G. G. Krueger et al., J. Am. Acad. Dermatol. 38, 186 (1998).

Cloprednol CAS Registry Number: 5251-34-3 氯泼尼醇

CAS Name: (11b)-6-Chloro-11,17,21-trihydroxypregna-1,4,6-triene-3,20-dione
Additional Names: 6-chloro-D1,4,6-pregnatriene-11b,17a,21-triol-3,20-dioneTrademarks: Cloradryn (Recordati); Novacort ...
Literature References: Prepn: H. J. Ringold, G. Rosenkranz, FR 1271981 C.A. 58, 1148a (1963); eidem, US 3232965 (1962, 1966 both to Syntex). Metabolic effects: E. Ortega et al., J. Clin. Pharmacol. 16, 122 (1976). Effects on hypothalamic-pituitary-adrenal axis function: eidem, J. Int. Med. Res. 4, 326 (1976). Bioavailability in humans: E. Mroszczak et al., J. Pharm. Sci. 67, 920 (1978). HPLC determn in plasma: C. Lee et al., ibid. 70, 669 (1981).