其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dioxybenzone CAS Registry Number: 131-53-3 二羟苯宗

CAS Name: (2-Hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone
Additional Names: 2,2'-dihydroxy-4-methoxybenzophenone; 4-methoxy-2,2'-dihydroxybenzophenone; benzophenone-8
Trademarks: Cyaso...
Literature References: Prepn: Hardy et al., US 2853521 (1958 to Am. Cyanamid).

Thozalinone CAS Registry Number: 655-05-0 托扎啉酮

CAS Name: 2-(Dimethylamino)-5-phenyl-4(5H)-oxazolone
Additional Names: 2-(dimethylamino)-5-phenyl-2-oxazolin-4-one; 5-phenyl-2-(dimethylamino)-2-oxazolin-4-one; tozalinone
Trademarks: Stimse...
Literature References: Prepn: Hardy, Jr. et al., US 3037990 (1962 to Am. Cyanamid). Pharmacological studies: B. M. Bernstein, C. N. Latimer, Psychopharmacologia 12, 338 (l968); U. H. Lindberg, J. Pedersen, Acta Pharm. Suec. 5, 15 (1968). In treatment of Parkinsonism: W. D. Gray, C. E. Edward, US 3665075 (1972 to Am. Cyanamid).

Gallacetophenone CAS Registry Number: 528-21-2 2',3',4'-三羟基苯乙酮

CAS Name: 1-(2,3,4-Trihydroxyphenyl)ethanone
Additional Names: 2',3',4'-trihydroxyacetophenone; Alizarine yellow C; C.I. 57000
Percent Composition: C 57.14%, H 4.80%, O 38.06%
Literature References: Prepn: Hart, Woodruff, J. Am. Chem. Soc. 58, 1957 (1936); Campbell, Coppinger, US 2686123 (1954 to U.S. Secy. Agr.); Knowles, US 2763691 (1956 to Kodak); Price, Israelstam J. Org. Chem. 29, 2800 (1964).

Hydrofuramide CAS Registry Number: 494-47-3 三呋喃甲醛二亚胺

CAS Name: 1-(2-Furanyl)-N,N'-bis(2-furanylmethylene)methanediamine
Additional Names: N,N'-difurfurylidene-2-furanmethanediamine; furfuramide
Percent Composition: C 67.16%, H 4.51%, N 10.44%,...
Literature References: Prepn: Hartley, Dobbie, J. Chem. Soc. 73, 598 (1898); Taniyama, J. Chem. Soc. Jpn. Ind. Chem. Sect. 51, 33 (1948); Kapur et al., J. Sci. Ind. Res. 19B, 509 (1960); Kamal et al., Tetrahedron 19, 869 (1963). Structure: Soundararajan, Anantakrishnan, Proc. Indian Acad. Sci. 38A, 176 (1953).

Thurfyl Nicotinate CAS Registry Number: 70-19-9 烟酸呋酯

CAS Name: Nicotinic acid tetrahydrofurfuryl ester
Additional Names: tetrahydrofurfuryl nicotinate; nicotafuryl
Trademarks: Trafuril (Novartis)
Percent Composition: C 63.75%, H 6.32%, N 6....
Literature References: Prepn: Hartmann, Merz, US 2485152 (1949 to Ciba). Brief review: A. A. Fisher, Cutis 51, 225-227 (1993).

Butanilicaine CAS Registry Number: 3785-21-5 盐酸布坦卡因

CAS Name: 2-(Butylamino)-N-(2-chloro-6-methylphenyl)acetamide
Additional Names: 2-(butylamino)-6'-chloro-o-acetotoluidide; w-n-butylaminoacetic acid 2-methyl-6-chloroanilide; 1-(butylaminoacety...
Literature References: Prepn: Häussler, Ther, Arzneim.-Forsch. 3, 609 (1953); GB 726080 (1955 to Polymer Corp.); GB 759744 (1956 to Cilag); GB 782971; G. Ehrhart et al., US 2912460 (1957, 1959 both to Hoechst); Epstein, Kaminsky, J. Am. Chem. Soc. 80, 1892 (1958). Structure activity study: P. P. Koelzer, K. H. Wehr, Arzneim.-Forsch. 8, 181 (1958).

Nifenazone CAS Registry Number: 2139-47-1 尼芬那宗

CAS Name: N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-pyridinecarboxamide
Additional Names: N-antipyrinylnicotinamide; 2,3-dimethyl-1-phenyl-4-(3-pyridinecarboxamido)-5-pyrazo...
Literature References: Prepn: Heid, DE 897407 (1953); Trommsdorff, BE 635597 (1963); Pongraz, Zirm, Monatsh. Chem. 88, 330 (1957); Zorn, Schmidt, Pharmazie 12, 396 (1957).

Nitrilotriacetic Acid CAS Registry Number: 139-13-9 氨三乙酸

CAS Name: N,N-Bis(carboxymethyl)glycine
Additional Names: triglycollamic acid; a,a',a''-trimethylaminetricarboxylic acid; tri(carboxymethyl)amine; triglycine; NTA
Percent Composition: C 37.7...
Literature References: Prepn: Heintz, Ann. 122, 260 (1862); Michaelis, Schubert, J. Biol. Chem. 106, 331 (1934); Martell, Bersworth, J. Org. Chem. 15, 46 (1950); Singer, Weisberg, US 2855428 and US 3061628 (1958 and 1962, both to Hampshire Chem.). IR studies: Nakamoto et al., J. Am. Chem. Soc. 84, 2081 (1962); Chapman et al., Proc. Chem. Soc. London 1962, 336. Solubility data: Bird, J. Soc. Dyers Colour. 56, 473 (1940). Toxicity data: Soap Chem. Spec. 42, 58 (1966). pK data: Schwarzenbach et al., Helv. Chim. Acta 28, 828 (1945). Review: Souchay, Graizon, Bull. Soc. Chim. Fr. 1952, 34.

Drometrizole CAS Registry Number: 2440-22-4 2-(2-羟基-5-苯甲基)苯并三唑

CAS Name: 2-(2H-Benzotriazol-2-yl)-4-methylphenol
Additional Names: 2-(2H-benzotriazol-2-yl)-p-cresol; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole
Trademarks: Tinuvin P (Ciba)
Percent Com...
Literature References: Prepn: Heller et al., US 3004896; US 3189615 (1961, 1965 to Geigy). Stabilization mechanism in acrylonitrile-butadiene-styrene (ABS) latex: J. B. Adeniyi, J. Polym. Mater. 3, 25 (1986). HPLC determn in plastic: B. Niklasson, B. Björkner, Contact Dermatitis 21, 330 (1989). Review of uses: Dunn, Fogg, J. Appl. Polym. Sci. 2, 367 (1959); of toxicology and cosmetic use: CTFA, J. Am. Coll. Toxicol. 5, 455-470 (1986).

Triclofos CAS Registry Number: 306-52-5 磷酸三氯乙酯

CAS Name: 2,2,2-Trichloroethanol dihydrogen phosphate
Additional Names: trichloroethyl phosphate
Percent Composition: C 10.47%, H 1.76%, Cl 46.37%, O 27.90%, P 13.50%
Literature References: Prepn: Hems et al., Br. Med. J. 1, 1834 (1962).