其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Butaperazine CAS Registry Number: 653-03-2 布他哌嗪

CAS Name: 1-[10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazin-2-yl]-1-butanone
Additional Names: 2-butyryl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine; N-[g-(4'-methyl-1'-piperazin...
Literature References: Prepn: Hoerlein et al., DE 1120451 (1961 to Bayer), C.A. 57, 4677c (1962).

Floxuridine CAS Registry Number: 50-91-9 5-氟-2'-脱氧脲核苷

CAS Name: 2'-Deoxy-5-fluorouridine
Additional Names: 1-(2-deoxy-b-D-ribofuranosyl)-5-fluorouracil; 5-fluoro-2'-deoxy-b-uridineTrademarks: FUDR (Roche)
Percent Composition: C 43.91%, H 4.50%,...
Literature References: Prepn: Hoffer et al., J. Am. Chem. Soc. 81, 4112 (1959); Heidelberger, Duschinsky, US 2885396 (1959); Duschinsky et al., US 2970139 (1961); Hoffer, US 2949451; US 3041335 (1960, 1962 both to Hoffmann-La Roche). Structure: Lemieux, Hoffer, Can. J. Chem. 39, 110 (1961). Crystal and molecular structure: Harris, Diss. Abstr. 24, 4425 (1964); Harris, McIntyre, Biophys. J. 4, 203 (1964). Conformation of furanose ring in molecule: Sundaralingam, J. Am. Chem. Soc. 87, 599 (1965).

Amitriptyline CAS Registry Number: 50-48-6 阿米替林

CAS Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
Additional Names: 10,11-dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-D5,g-propylamine; 5-(g-dimet...
Literature References: Prepn: Hoffsommer et al., J. Org. Chem. 27, 4134 (1962); 28, 1751 (1963); J. Med. Chem. 8, 555 (1965); Engelhardt et al., BE 584061 (1960 to Merck Co.); GB 858187; GB 858188 (both 1961 to Hoffmann-La Roche); Tristram, Tull, US 3205264 (1965 to Merck Co.). Toxicity data: A. Tobe et al., Arzneim.-Forsch. 31, 1278 (1981). Comprehensive description: K. W. Blessel et al., Anal. Profiles Drug Subs. 3, 127-148 (1974).

Octacaine CAS Registry Number: 13912-77-1 奥他卡因

CAS Name: 3-(Diethylamino)-N-phenylbutanamide
Additional Names: 3-diethylaminobutyranilide
Percent Composition: C 71.75%, H 9.46%, N 11.95%, O 6.83%
Literature References: Prepn: Hofstetter, Wilder Smith, Helv. Chim. Acta 36, 1698 (1953); Hofstetter, US 2851393 (1958 to E. Geistlich Söhne).

Fluprednisolone CAS Registry Number: 53-34-9 6-α-氟泼尼龙

CAS Name: (6a,11b)-6-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
Additional Names: 6a-fluoroprednisolone; 6a-fluoro-1,4-pregnadiene-11b,17a,21-triol-3,20-dione; 6a-fluoro-1-dehydrohyd...
Literature References: Prepn: Hogg, Spero, US 2841600 (1958 to Upjohn); Batres et al., DE 1079042 (1960 to Syntex); Lettré, Hotz, DE 1088953 (1960 to Bayer).

Dimetacrine CAS Registry Number: 4757-55-5 二甲他林

CAS Name: N,N,9,9-Tetramethyl-10(9H)-acridinepropanamine
Additional Names: 10-[3-(dimethylamino)propyl]-9,9-dimethylacridan; 5,5-dimethyl-10-dimethylaminopropylacridan; dimethacrine
Percent ...
Literature References: Prepn: Holm, GB 933875 (1963 to Kefalas), C.A. 60, 510a (1964); Molnar, Wagner-Jauregg, Helv. Chim. Acta 48, 1782 (1965); FR 1438357 (1966 to Siegfried), C.A. 66, 10856k (1967). Pharmacology and metabolism: Schatz et al., Arzneim.-Forsch. 18, 862 (1968); Ishitani et al., Jpn. J. Pharmacol. 20, 432 (1970).

tert-Butylacetic Acid CAS Registry Number: 1070-83-3 3,3-二甲基丁酸

CAS Name: 3,3-Dimethylbutanoic acid
Additional Names: 3,3-dimethylbutyric acid
Percent Composition: C 62.04%, H 10.41%, O 27.55%
Literature References: Prepn: Homeyer et al., J. Am. Chem. Soc. 55, 4209 (1933); Botterson, Shulman, J. Org. Chem. 27, 1059 (1962); A. Nilsson, R. Carlson, Acta Chem. Scand. B34, 621 (1980).

Histapyrrodine CAS Registry Number: 493-80-1 希司吡定

CAS Name: N-Phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine
Additional Names: 1-[2-(N-benzylanilino)ethyl]pyrrolidine; N-pyrrolidylethyl-N-phenylbenzylamine; N-benzyl-N-phenylpyrrolidinoethylam...
Literature References: Prepn: Hopff et al., US 2623880 (1952). Chemical properties: Auterhoff, Arch. Pharm. 284, 123 (1951).

Chloracizine CAS Registry Number: 800-22-6 氯拉西嗪

CAS Name: 2-Chloro-10-[3-(diethylamino)-1-oxopropyl]-10H-phenothiazine
Additional Names: 2-chloro-10-(N,N-diethyl-b-alanyl)phenothiazine; 10-(b-diethylaminopropionyl)-2-chlorophenothiazine; 2-c...
Literature References: Prepn: Horclois, Metivier, FR 1060715 (1954 to Rhône Poulenc); GB 740932 (1955); Zhuravlev, Gritsenko, Zh. Obshch. Khim. 26, 3385 (1956), C.A. 51, 9623h (1957). For other prepns in Russian journals see C.A. 55, 6484b, 9425a (1961).

Homocamfin CAS Registry Number: 535-86-4

CAS Name: 3-Methyl-5-(1-methylethyl)-2-cyclohexen-1-one
Additional Names: m-menth-6-en-5-one; methylisopropylcyclohexenone; 5-isopropyl-3-methyl-D2-cyclohexenone
Trademarks: Cyclosal; Hexeto...
Literature References: Prepn: Horning et al., J. Org. Chem. 9, 547 (1944); Whitmore, Roberts, ibid. 13, 31 (1948).