其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Vamicamide CAS Registry Number: 132373-81-0 (2R,4R)-4-二甲基氨基-2-苯基-2-吡啶-2-基戊酰胺

CAS Name: (aR)-rel-a-[(2R)-2-(Dimethylamino)propyl]-a-phenyl-2-pyridineacetamide
Additional Names: 4-dimethylamino-2-phenyl-2-(2-pyridyl)valeramidePercent Composition: C 72.70%, H 7.80%, N 14.1...
Literature References: Prepn: I. Ueda et al., EP 105458; eidem, US 4564621 (1984, 1986 both to Fujisawa); H. Oyasu et al., J. Med. Chem. 37, 1378 (1994). Comparative pharmacology: idem et al., Arzneim.-Forsch. 44, 1242 (1994); T. Yamamoto et al., Drug Dev. Res. 34, 9 (1995). HPLC determn of enantiomers in serum and urine: A. Suzuki et al., J. Chromatogr. 617, 279 (1993). Clinical pharmacokinetics: M. Terakawa, N. Iyota, Yakubutsu Dotai 9, 799 (1994), C.A. 122, 204469g (1995).

Carbazochrome Sodium Sulfonate CAS Registry Number: 51460-26-5 卡络磺钠

CAS Name: 5-[(Aminocarbonyl)hydrazono]-2,3,5,6-tetrahydro-1-methyl-6-oxo-1H-indole-2-sulfonic acid monosodium salt
Additional Names: 5,6-dihydro-1-methyl-5,6-dioxo-2-indolinesulfonic acid 5-sem...
Literature References: Prepn: Iwao, Pharm. Bull. 4, 251 (1956), C.A. 51, 6860f (1957); GB 795184 (1958 to Gohei Tanabe). Revision of structure from a 3- to a 2-sulfonic acid: Kawazu et al., J. Heterocycl. Chem. 10, 1059 (1973).

Nifurfoline CAS Registry Number: 3363-58-4 硝呋复林

CAS Name: 3-(4-Morpholinylmethyl)-1-[[(5-nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione
Additional Names: 3-(morpholinomethyl)-1-[(5-nitrofurfurylidene)amino]hydantoin
Trademarks: U...
Literature References: Prepn: J. A. Bofill-Auge, J. M. Espinos-Taya, ES 297087 (1964), C.A. 63, 11572e (1966); GB 1245095 (1971 to Esteve), C.A. 75, 121382h (1971).

p-Aminohippuric Acid CAS Registry Number: 61-78-9 4-氨基马尿酸

CAS Name: N-(4-Aminobenzoyl)glycine
Additional Names: N-(p-aminobenzoyl)aminoacetic acid; PAH
Percent Composition: C 55.67%, H 5.19%, N 14.43%, O 24.72%
Literature References: Prepn: J. B. Muenzen et al., J. Biol. Chem. 67, 469 (1926). Method to determine renal function: L. Schumann, P. W. Wüstenberg, Clin. Nephrol. 33, 35 (1990); R. A. Gabel et al., J. Pharmacol. Toxicol. Methods 36, 189 (1996).

Tolazamide CAS Registry Number: 1156-19-0 妥拉磺脲

CAS Name: N-[[(Hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methylbenzenesulfonamide
Additional Names: 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea; N-(p-toluenesulfonyl)-N'-hexamethyleni...
Literature References: Prepn: J. B. Wright, GB 887886 (1962 to Upjohn); J. B. Wright, R. E. Willette, J. Med. Pharm. Chem. 5, 815 (1962). Pharmacology: W. E. Dulin et al., Proc. Soc. Exp. Biol. Med. 107, 245 (1961). Mode of action study: Marshall et al., Metab. Clin. Exp. 19, 1046 (1970). Clinical experience and review of early literature: Balodimos, Marble, Curr. Ther. Res. 13, 6-12 (1971). Clinical bioavailability and pharmacokinetics: P. G. Welling et al., J. Pharm. Sci. 71, 1259 (1982). Structural studies: C. H. Koo et al., Arch. Pharmacal Res. 11, 74 (1988). HPLC determn in serum: B. J. Starkey et al., J. Liq. Chromatogr. 12, 1889 (1989). Comprehensive description: J. K. Lee et al., Anal. Profiles Drug Subs. Excip. 22, 489-516 (1993).

Flutrimazole CAS Registry Number: 119006-77-8 氟曲马唑

CAS Name: 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
Additional Names: 1-[o-fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazoleTrademarks: Micetal (Uriach)
Percent Composit...
Literature References: Prepn: J. Bartroli, M. Anguita, EP 352352; eidem, US 5149707 (1990, 1992 both to Uriach). Series of articles on synthesis, antifungal activity, pharmacokinetics: Arzneim.-Forsch. 42, 832-863 (1992). Toxicity study: M. L. Vericat et al., ibid. 841. Clinical trial in dermatomycoses: O. Binet et al., Mycoses 37, 455 (1994).

Clofoctol CAS Registry Number: 37693-01-9 叔辛酚氯

CAS Name: 2-[(2,4-Dichlorophenyl)methyl]-4-(1,1,3,3-tetramethylbutyl)phenol
Additional Names: a-(2,4-dichlorophenyl)-4-(1,1,3,3-tetramethylbutyl)-o-cresol
Trademarks: Gramplus (Chiesi); Octo...
Literature References: Prepn: J. Debat, US 3830852 (1974 to Inst. Recherches Chim. Biol. Appl.). Activity against gram positive and gram negative bacteria: A. Buogo, Drugs Exp. Clin. Res. 10, 321 (1984). Pharmacokinetics in rats: M. Del Tacca et al. in Recent Advances in Chemotherapy, Antimicrobial Section 3, J. Ishigami, Ed. (University of Tokyo Press, 1985) pp 1927-28; in man: eidem, J. Antimicrob. Chemother. 19, 679 (1987). Mechanism of action: J. Combe et al., J. Pharmacol. 11, 411 (1980); F. Yablonsky, G. Simonet, ibid. 13, 515 (1982). Clinical trials in respiratory infections: J. Vialatte, Diagnostics 207, 65 (1978); in infectious bronchopulmonary diseases: R. Danesi, M. Del Tacca, Int. J. Clin. Pharmacol. Res. 5, 175 (1985); in ear, nose and throat infections: P. L. Ghilardi, A. Casani, Drugs Exp. Clin. Res. 11, 815 (1985).

Denatonium Benzoate CAS Registry Number: 3734-33-6 苯甲地那铵

CAS Name: N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]-N,N-diethylbenzenemethanaminium benzoate
Additional Names: benzyldiethyl[(2,6-xylylcarbamoyl)methyl]ammonium benzoate; lignocaine benzyl b...
Literature References: Prepn: J. E. Hay, US 3080327 (1963 to T. H. Smith Ltd.); idem, US 3268575 (1966 to Edinburgh Pharm. Ind.). HPLC determn in rapeseed oil: C. E. Damon, B. C. Pettitt, Jr., J. Chromatogr. 195, 243 (1980). Brief review of substance history and uses: H. A. S. Payne, Chem. Ind. (London) 22, 721-723 (1988).

Isoflupredone CAS Registry Number: 338-95-4 异氟泼尼松

CAS Name: (11b)-9-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
Additional Names: 1-dehydro-9a-fluorohydrocortisone; 9-fluoroprednisolone
Percent Composition: C 66.65%, H 7.19%, F 5....
Literature References: Prepn: J. Fried et al., J. Am. Chem. Soc. 77, 4181 (1955). Microbiological prepn: A. Nobile et al., J. Am. Chem. Soc. 77, 4184 (1955); E. Vischer et al., Helv. Chim. Acta 38, 1502 (1955); T. H. Stoudt et al., Arch. Biochem. Biophys. 59, 304 (1955). Prepn of the 21-acetate: R. F. Hirschmann et al., ibid. 3166; J. A. Hogg et al., ibid. 4438; Ch. Meystre et al., Helv. Chim. Acta 39, 734 (1956); A. Wellstein et al., DE 1020329 (1957 to Ciba), C.A. 54, 25562h (1960); GB 843214 (1960 to Schering), C.A. 55, 5597b (1961). Absorption spectra: L. L. Smith, W. H. Muller, J. Org. Chem. 23, 960 (1958). Mass spectrometry: P. Toft et al., Can. J. Pharm. Sci. 7, 53 (1972). Urinary excretion in horses: D. I. Chapman et al., Vet. Rec. 100, 447 (1977).

Fludrocortisone CAS Registry Number: 127-31-1 氟氢可的松

CAS Name: (11b)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione
Additional Names: 9a-fluorohydrocortisone; 9a-fluoro-17-hydroxycorticosterone; 9a-fluorocortisol; fluodrocortisone; fluohydris...
Literature References: Prepn: J. Fried, E. F. Sabo, J. Am. Chem. Soc. 76, 1455 (1954); GB 792224; J. Fried, US 2852511 (both 1958 to Olin Mathieson). Series of articles on pharmacology and metabolism: Arzneim.-Forsch. 21, 1103-1158 (1971). Comprehensive description of the acetate: K. Florey, Anal. Profiles Drug Subs. 3 281-306 (1974).