其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Nicoclonate CAS Registry Number: 10571-59-2 尼可氯酯

CAS Name: 3-Pyridinecarboxylic acid 1-(4-chlorophenyl)-2-methylpropyl ester
Additional Names: nicotinic acid p-chloro-a-isopropylbenzyl ester; 1-(p-chlorophenyl)isobutyl nicotinate; p-chlorophe...
Literature References: Prepn: J. Nordmann, H. B. Swierkot, FR M3454; eidem, US 3367939 (1965, 1968 both to Kuhlmann).

Bufeniode CAS Registry Number: 22103-14-6 丁苯碘胺

CAS Name: 4-Hydroxy-3,5-diiodo-a-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzenemethanol
Additional Names: 1-(4-hydroxy-3,5-diiodophenyl)-2-(1-methyl-3-phenylpropylamino)propanol; diiodobuphen...
Literature References: Prepn: J. P. Fourneau, J. M. Delourme, ZA 6800046; eidem, US 3542870 (1968, 1970 both to Lab. Houdé). Metabolism: Veyre et al., C.R. Seances Soc. Biol. Ses Fil. 163, 136 (1969).

Propetamphos CAS Registry Number: 31218-83-4 异丙氧磷

CAS Name: (E)-3-[[(Ethylamino)methoxyphosphinothioyl]oxy]-2-butenoic acid 1-methylethyl ester
Additional Names: (E)-3-hydroxycrotonic acid isopropyl ester O-ester with O-methyl ethylphosphorami...
Literature References: Prepn: J. P. Leber, K. Lutz, DE 2035103 corresp to US 3758645 (1971, 1973 to Sandoz). Activity: W. Berg, R. Gothe, Proc. Br. Crop Prot. Conf. - Pests Dis. 1979, 517.

Fluocinolone Acetonide CAS Registry Number: 67-73-2 醋酸氟轻松

CAS Name: (6a,11b,16a)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
Additional Names: 6a,9a-difluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-...
Literature References: Prepn: J. S. Mills et al., J. Am. Chem. Soc. 82, 3399 (1960); J. S. Mills, A. Bowers, US 3014938; H. J. Ringold et al., US 3126375 (1961, 1964 both to Syntex). IR spectrum: Sammul et al., J. Assoc. Off. Agric. Chem. 47, 952 (1964).

Ibufenac CAS Registry Number: 1553-60-2 异丁芬酸

CAS Name: 4-(2-Methylpropyl)benzeneacetic acid
Additional Names: (p-isobutylphenyl)acetic acid; p-isobutyl-a-toluic acid
Trademarks: Dytransin; Ibunac (Kaken)
Percent Composition: C 74.97...
Literature References: Prepn: J. S. Nicholson, S. S. Adams, GB 971700; eidem, US 3385887 (1964, 1968 both to Boots Pure Drug). Pharmacology: S. S. Adams et al., J. Pharm. Pharmacol. 20, 305 (1968). Toxicity data: S. S. Adams et al., Nature 200, 271 (1962).

Acepromazine CAS Registry Number: 61-00-7 乙酰丙嗪

CAS Name: 1-[10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]ethanone
Additional Names: 10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl ketone; 2-acetyl-10-(3-dimethylaminopropyl)phenot...
Literature References: Prepn: J. Schmitt et al., Bull. Soc. Chim. Fr. 1957, 938. Pharmacology and toxicology: W. Wirth et al., Arch. Int. Pharmacodyn. 123, 78 (1959). GLC determn in plasma: S. Ballard, T. Tobin, J. Toxicol. Environ. Health 7, 745 (1981). Clinical trial in cats: D. H. Dyson et al., Can. Vet. J. 33, 462 (1992); in horses: A. Hashem, H. Keller, J. Vet. Pharmacol. Ther. 16, 359 (1993). Brief review of clinical experience: N. Brock, Can. Vet. J. 35, 458-459 (1994).

Benfurodil Hemisuccinate CAS Registry Number: 3447-95-8 琥珀苯呋地尔

CAS Name: Butanedioic acid mono[1-[5-(2,5-dihydro-5-oxo-3-furanyl)-3-methyl-2-benzofuranyl]ethyl] ester
Additional Names: succinic acid monoester with 4-[2-(1-hydroxyethyl)-3-methyl-5-benzofura...
Literature References: Prepn: J. Schmitt, FR 1408721; idem, US 3355463 (1965, 1967 to Clin-Byla). Prepn and toxicity: J. Schmitt et al., Bull. Soc. Chim. Fr. 1967, 74. Synthesis and pharmacology: eidem, Chim. Ther. 1, 305 (1966).

Amoxapine CAS Registry Number: 14028-44-5 阿莫沙平

CAS Name: 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepineTrademarks: Asendin (Lederle); Asendis (Wyeth); Defanyl (Lederle); Demolox (Am. Cyanamid); Moxadil (Lederle)
Percent Composition: C...
Literature References: Prepn: J. Schmutz et al., Helv. Chim. Acta 50, 245 (1967); eidem, Chim. Ther. 2, 424 (1967); C. F. Howell et al., FR 1508536; eidem, US 3663696 (1968, 1972 both to Am. Cyanamid). Analysis of amoxapine and its metabolites by GLC: T. B. Cooper, R. G. Kelly, J. Pharm. Sci. 68, 216 (1979). X-ray crystallography: D. B. Cosulich, F. M. Lovell, Acta Crystallogr. B33, 1147 (1977). Pharmacology: E. N. Greenblatt et al., Arch. Int. Pharmacodyn. Ther. 233, 107 (1978). Clinical study: R. Takahashi et al., J. Int. Med. Res. 7, 7 (1979). Review: T. A. Ban, Psychopharmacol. Bull. 15, 22-25 (1979); E. N. Greenblatt et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 2, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1979) pp 1-18. Review of pharmacology and therapeutic efficacy: S. G. Jue et al., Drugs 24, 1-23 (1982).

Azodicarbonamide CAS Registry Number: 123-77-3 偶氮二甲酰胺

CAS Name: Diazenedicarboxamide
Additional Names: 1,1'-azobisformamide; azodicarboxamide; azobiscarbonamide; azobiscarboxamide; 1,1'-azobiscarbamide
Percent Composition: C 20.69%, H 3.47%, N ...
Literature References: Prepn: J. Thiele, Ann. 270, 1 (1892); 271, 127 (1892); T. Curtis, K. Heindenreich, J. Prakt. Chem. [2] 52, 454 (1895); J. P. Picard, J. L. Boivin, Can. J. Chem. 29, 223 (1951). Crystal structure: D. T. Cromer, A. C. Larson, J. Chem. Phys. 60, 176 (1974). Safety assessment as a flour-maturing agent: B. L. Oser et al., Toxicol. Appl. Pharmacol. 7, 445 (1965).

Tetrahydrothiophene CAS Registry Number: 110-01-0 四氢噻吩(THT)

Additional Names: Tetramethylene sulfide; thiacyclopentane; THT; THTP
Percent Composition: C 54.49%, H 9.15%, S 36.37%
Literature References: Prepn: J. v. Braun, A. Trümpler, Ber. 43, 545 (1910); J. K. Lawson et al., Org. Synth. coll. vol. IV, 892 (1963). Method for odorizing liquified natural gas: D. K. Mulliner, Proc., Opec. Sect., Am. Gas Assoc. D, 27 (1974). GC/MS determn in water: G. Carlucci et al., J. Chromatogr. 287, 425 (1984). On-site GC determn in natural gas: R. C. M. de Nijs et al., J. High Resolut. Chromatogr. 16, 379 (1993).