其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Acediasulfone CAS Registry Number: 80-03-5 N-[4-[(4-氨基苯基)磺酰基]苯基]甘氨酸

CAS Name: N-[4-[(4-Aminophenyl)sulfonyl]phenyl]glycine
Additional Names: N-p-sulfanilylphenylglycine; p-amino-p'-(carboxymethylamino)diphenyl sulfone; 4-carboxymethylamino-4'-aminodiphenylsulfo...
Literature References: Prepn: Jackson, J. Am. Chem. Soc. 70, 680 (1948); CH 254803 and CH 278482 (1949, 1952, to Cilag Ltd.); Rawlins, US 2589211 (1952 to Parke, Davis).

Indolebutyric Acid CAS Registry Number: 133-32-4 3-吲哚丁酸

CAS Name: 1H-Indole-3-butanoic acid
Additional Names: indole-3-butyric acid; 4-(3-indolyl)butyric acid
Trademarks: Seradix (Rhone-Poulenc)
Percent Composition: C 70.92%, H 6.45%, N 6.89%,...
Literature References: Prepn: Jackson, Manske, J. Am. Chem. Soc. 52, 5029 (1930); by heating indole, g-butyrolactone, and sodium hydroxide, followed by acidification of the product: Fritz, US 3051723 (1962 to Union Carbide); by decarboxylation of 2-carboxyindole-3-butyric acid: Bowman, Islip, Chem. Ind. (London) 1971, 154. Toxicity studies: Anderson et al., Proc. Soc. Exp. Biol. Med. 34, 138 (1936); Pesonen, Acta Endocrinol. 5, 409 (1950). Hypoglycemic effect in rats: Mirsky et al., Endocrinology 59, 715 (1956).

Levophacetoperane CAS Registry Number: 24558-01-8 左法哌酯

CAS Name: a-Phenyl-2-piperidinemethanol acetate
Additional Names: threo-1-acetoxy-1-phenyl-1-(2-piperidyl)methane; acetic acid a-phenyl-2-piperidylmethyl ester; 1-phenyl-1-(2'-piperidyl)-1-acet...
Literature References: Prepn: Jacob, Joseph, US 2928835 (1960 to Rhône-Poulenc).

Trimipramine CAS Registry Number: 739-71-9 三甲丙咪嗪

CAS Name: 10,11-Dihydro-N,N,b-trimethyl-5H-dibenz[b,f]azepine-5-propanamine
Additional Names: 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,f]azepine; 5-(3-dimethylamino-2-meth...
Literature References: Prepn: Jacob, Messer, Compt. Rend. 252, 2117 (1961). Toxicity studies: Okamoto, C.A. 72, 77299y (1970). Chemistry: Bever, Bredenstein, Dtsch. Apoth. Ztg. 113, 1562 (1973). Comprehensive description of the maleate: A. A. Al-Badr, Anal. Profiles Drug Subs. 12, 683-712 (1983).

Metopimazine CAS Registry Number: 14008-44-7 美托哌丙嗪

CAS Name: 1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-4-piperidinecarboxamide
Additional Names: 1-[3-[2-(methylsulfonyl)phenothiazin-10-yl]propyl]isonipecotamide; 10-[3-(4-carbamoyl...
Literature References: Prepn: Jacob, Robert, DE 1092476 (to Rhône-Poulenc), C.A. 56, 8723h (1962). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Etymemazine CAS Registry Number: 523-54-6 乙异丁嗪

CAS Name: 2-Ethyl-N,N,b-trimethyl-10H-phenothiazine-10-propanamine
Additional Names: 10-[3-(dimethylamino)-2-methylpropyl]-2-ethylphenothiazine; 3-ethyl-10-(3-dimethylamino-2-methylpropyl)pheno...
Literature References: Prepn: Jacob, Robert, US 2837518 (1958 to Rhône-Poulenc). Activity studies in pigs: Lambrerth, Aust. Vet. J. 44, 333 (1968). Biotransformation studies: Robinson, J. Pharm. Pharmacol. 18, 19 (1966).

Cyamemazine CAS Registry Number: 3546-03-0 氰美马嗪

CAS Name: 10-[3-(Dimethylamino)-2-methylpropyl]-10H-phenothiazine-2-carbonitrile
Additional Names: 2-cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazine; 10-(3-dimethylamino-2-methylpropyl)-...
Literature References: Prepn: Jacob, Robert, US 2877224 (1959 to Rhône-Poulenc). Synthesis: Craig et al., J. Org. Chem. 26, 1138 (1961). Biotransformation studies: Robinson, J. Pharm. Pharmacol. 18, 19 (1966). Chemistry: Kiger, Kiger, Ann. Pharm. Fr. 23, 489 (1965).

Oxomemazine CAS Registry Number: 3689-50-7 奥索马嗪

CAS Name: N,N,b-Trimethyl-10H-phenothiazine-10-propanamine 5,5-dioxide
Additional Names: 10-(3-dimethylamino-2-methylpropyl)phenothiazine 5,5-dioxide; 3-(9,9-dioxo-10-phenothiazinyl)-2-methyl-1...
Literature References: Prepn: Jacob, Robert, US 2972612 (1961 to Rhône-Poulenc).

Nitarsone CAS Registry Number: 98-72-6 硝苯胂酸

CAS Name: 4-Nitrophenylarsonic acid
Additional Names: p-nitrobenzenearsonic acid
Percent Composition: C 29.17%, H 2.45%, As 30.33%, N 5.67%, O 32.38%
Literature References: Prepn: Jacobs et al., J. Am. Chem. Soc. 40, 1580 (1918); Doak, Freedman, US 2653160 (1953 to the U.S.A. as represented by the Administrator of the Federal Security Agency); Ruddy, Starkey, Org. Synth. coll. vol. III, 665 (1955).

Docusate Sodium CAS Registry Number: 577-11-7 多库脂钠

CAS Name: Sulfobutanedioic acid 1,4-bis(2-ethylhexyl) ester sodium salt
Additional Names: sulfosuccinic acid 1,4-bis(2-ethylhexyl) ester S-sodium salt; bis(2-ethylhexyl)sodium sulfosuccinate; d...
Literature References: Prepn: Jaeger, US 2028091; US 2176423 (1936, 1939, both to Am. Cyanamid). Structure and wetting power: Caryl, Ind. Eng. Chem. 33, 731 (1941). Comprehensive description: S. Ahuja, J. Cohen, Anal. Profiles Drug Subs. 2, 199-219 (1973); 12, 713-720 (1983). For structure see Docusate calcium.