其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Gardol® CAS Registry Number: 137-16-6 N-月桂酰肌氨酸钠

CAS Name: N-Methyl-N-(1-oxododecyl)glycine sodium salt
Additional Names: N-lauroylsarcosine sodium salt; sodium N-lauroyl sarcosinate
Trademarks: Medialan LL-99
Percent Composition: C 61....
Literature References: Prepn: Jungermann et al., J. Am. Chem. Soc. 78, 172 (1956).

Penethamate Hydriodide CAS Registry Number: 808-71-9 喷沙西林氢碘酸盐

CAS Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 2-(diethylamino)ethyl ester monohydriodide
Additional Names: penicillin G 2-d...
Literature References: Prepn: K. A. Jensen et al., Ugeskr. Laeg. 112, 1043, 1075 (1950); E. K. Frederiksen, E. J. Nielsen, US 2694061; A. B. A. Jansen, J. C. Hamlet, US 2880203 (1954, 1959 both to Lövens). Selective concentration in lung: A. G. S. Heathcote, E. Nassau, Lancet 260, 1255 (1951). Properties: W. A. Woodard, J. Pharm. Pharmacol. 4, 1009 (1952). Veterinary trial in cows: G. Ziv, M. Storper, J. Vet. Pharmacol. Ther. 8, 276 (1985).

Viloxazine CAS Registry Number: 46817-91-8 维洛沙秦

CAS Name: 2-[(2-Ethoxyphenoxy)methyl]morpholine
Additional Names: 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazinePercent Composition: C 65.80%, H 8.07%, N 5.90%, O 20.23%
Literature References: Prepn: K. B. Mallion et al., GB 1138405; eidem, US 3714161 (1969, 1973 both to I.C.I.). Manufacturing process: S. A. Lee, GB 1260886; idem, US 3712890 (1972, 1973 both to I.C.I.). Pharmacology: Mallion et al., Nature 238, 157 (1972); Bereen, Lancet 1, 379 (1973). Toxicity: R. D. Brosnan et al., J. Int. Med. Res. 4, 83 (1976). Clinical evaluation in narcolepsy: C. Guilleminault et al., Sleep 9, 275 (1986). Review of pharmacology and therapeutic efficacy: R. M. Pinder et al., Drugs 13, 401 (1977).

Metamitron CAS Registry Number: 41394-05-2 苯嗪草酮

CAS Name: 4-Amino-3-methyl-6-phenyl-1,2,4-triazin-5(4H)-oneTrademarks: Goltix (Bayer)
Percent Composition: C 59.40%, H 4.98%, N 27.71%, O 7.91%
Literature References: Prepn: K. Dickore et al., DE 2107757; eidem, US 3847914 (1972, 1974 both to Bayer); W. Draber et al., Ann. 1976, 2206. Chemistry and mode of action: idem et al., Proc. 8th Int. Plant Prot. Congress 1, 203 (1975). Comprehensive description: H. Lembrich, Pflanzenschutz-Nachr. 31, 197 (1978). Degradation in soil: R. Allen, A. Walker, Pestic. Sci. 18, 95 (1987). HPLC determn in surface water: R. B. Geerdink, J. Chromatogr. 543, 244 (1991).

Prenoxdiazine Hydrochloride CAS Registry Number: 982-43-4 1-[2-[3-(2,2-二苯基乙基)-1,2,4-噁二唑-5-基]乙基]哌啶盐酸盐

CAS Name: 1-[2-[3-(2,2-Diphenylethyl)-1,2,4-oxadiazol-5-yl]ethyl]piperidine monohydrochloride
Additional Names: 3-(b,b-diphenylethyl)-5-(b-piperidinoethyl)-1,2,4-oxadiazole hydrochlorideTradema...
Literature References: Prepn: K. Harsanyi et al., HU 151748 (1964 to Chinoin), C.A. 62, 11821f (1965). Pharmacology: L. Tardos, I. Erdély, Arzneim.-Forsch. 16, 617 (1966). Stability study: E. Pandula et al., Acta Pharm. Hung. 38, 68 (1968). Review of pharmacology and clinical studies: K. Harsanyi et al., Boll. Chim. Farm. 112, 691 (1973).

Oxendolone CAS Registry Number: 33765-68-3 奥生多龙

CAS Name: (16b,17b)-16-Ethyl-17-hydroxyestr-4-en-3-one
Additional Names: 16b-ethyl-19-nortestosteroneTrademarks: Prostetin (Takeda)
Percent Composition: C 79.42%, H 10.00%, O 10.58%
Literature References: Prepn: K. Hiraga et al., DE 2100319; eidem, US 3856829 (1971, 1974 both to Takeda); K. Yoshioka et al., Chem. Pharm. Bull. 23, 3203 (1975). Stereoselective synthesis and NMR study: G. Goto et al., ibid. 25, 1295 (1977). Synthesis and anti-androgenic activity: eidem, ibid. 26, 1718 (1978). Physico-chemical properties and stabilities: K. Itakura et al., Takeda Kenkyushoho 37, 297 (1978), C.A. 91, 20879 (1979). Disposition and metabolism: S. Tanayama et al., Steroids 33, 65 (1979). Series of articles on pharmacology, mechanism of action, anti-androgen effects: Acta Endocrinol. 92 (Suppl 2), 1-107 (1979).

Ozagrel CAS Registry Number: 82571-53-7 奥扎格雷

CAS Name: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid
Additional Names: (E)-4-(imidazol-1-ylmethyl)cinnamic acidPercent Composition: C 68.41%, H 5.30%, N 12.27%, O 14.02%
Literature References: Prepn: K. Iizuka et al., DE 2923815; eidem, US 4226878 (both 1980 to Ono; Kissei). Synthesis and thromboxane synthetase inhibitory activity: K. Iizuka et al., J. Med. Chem. 24, 1139 (1981). Pharmacology: S. Hiraku et al., Jpn. J. Pharmacol. 41, 393 (1986). Pulmonary vascular effects: R. Garcia-Szabo et al., Prostaglandins 28, 851 (1984). Metabolism in animals: M. Shimizu et al., Iyakuhin Kenkyu 17, 289 (1986), C.A. 105, 72012q (1986). HPLC determn in biological fluids: eidem, ibid. 298, C.A. 105, 72013r (1986). Clinical pharmacology and evaluation in myocardial infarction: T. Ito et al., Biomed. Biochim. Acta 43, S125 (1984). Clinical evaluation in prevention of cerebral vasospasm: S. Suzuki et al., Acta Neurochir. 77, 133 (1985); in coronary artery disease: M. Shikano et al., Jpn. Heart J. 28, 663 (1987). Toxicity data: T. Nishigake et al., Clin. Rep. 20, 2671 (1986). Series of articles on pharmacology: Pharmacometrics 31, 527-565 (1986), C.A. 105, 35349-35352 (1986).

Monosodium Glutamate CAS Registry Number: 142-47-2 谷氨酸钠

CAS Name: L-Glutamic acid monosodium salt
Additional Names: sodium glutamate; Chinese seasoning; MSGTrademarks: Accent (Underwood); Aji-no-moto (Suzuki)
Percent Composition: C 35.51%, H 4.77...
Literature References: Prepn: K. Ikeda, S. Suzuki, GB 9440 (1910), C.A. 5, 836 (1910). Commercial prepn: P. R. Shildneck, US 2306646 (1942 to Staley Manuf.). Determn in food by HPLC: A. T. Rhys Williams, S. A. Winfield, Analyst 107, 1092 (1982); by LC: O.W. Lau, C. S. Mok, Anal. Chim. Acta 302, 45 (1995). Review of use and biological effects: Food. Technol. 41, 143-154 (1987). Review: T. Kawakita, "L-Monosodium Glutamate (MSG)" in Kirk-Othmer Encyclopedia of Chemical Technology Vol. 2 (John Wiley Sons, New York, 4th ed., 1992) pp 571-579. Review of toxicology: O. U. Eka et al., Biokemistri 4, 57-73 (1994). Book: Glutamic Acid: Advances in Biochemistry and Physiology L. J. Filer et al., Eds. (Raven Press, New York, 1979) 416 pp.

Clanobutin CAS Registry Number: 30544-61-7 利胆丁酸

CAS Name: 4-[(4-Chlorobenzoyl)(4-methoxyphenyl)amino]butanoic acid
Additional Names: 4-[p-chloro-N-(p-methoxyphenyl)benzamido]butyric acid; N-(p-chlorobenzoyl)-g-(p-anisidino)butyric acid
Tr...
Literature References: Prepn: K. Klemm et al., DE 1917036; eidem, US 3780095 (1971, 1973 both to Byk-Gulden). Series of articles on synthesis, physical and pharmacological properties: Arzneim.-Forsch. 29, 1-15 (1979). In vitro biochemical study: H. Wolf et al., Biochem. Pharmacol. 29, 1649 (1980). Effect on bile excretion in rats, dogs: P. Berchtold et al., Arzneim.-Forsch. 30, 1878 (1980).

Emorfazone CAS Registry Number: 38957-41-4 依莫法宗

CAS Name: 4-Ethoxy-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinoneTrademarks: Nandron (Morishita); Pentoyl (Morishita)
Percent Composition: C 55.22%, H 7.16%, N 17.56%, O 20.06%
Literature References: Prepn: K. Satoda et al., JP 72 24030 (1972 to Morishita), C.A. 77, 164732f (1972); M. Takaya et al., J. Med. Chem. 22, 53 (1979). Metabolism studies: T. Hayashi et al., Chem. Pharm. Bull. 26, 3124 (1978); 27, 317 (1979). General pharmacological study: M. Sato et al., Nippon Yakurigaku Zasshi 75, 291 (1979), C.A. 91, 117292 (1979). Mechanism of action studies: M. Sato, A. Yamaguchi, Arzneim.-Forsch. 32, 379 (1982). Antigenicity study: M. Sato et al., Oyo Yakuri 18, 65 (1979), C.A. 92, 104391 (1980). Toxicity studies: eidem, ibid. 16, 1011 (1978), C.A. 90, 197741 (1979); C. Onodera et al., J. Toxicol. Sci. 4, 229 (1979); K. Shimpo et al., ibid. 255.