其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Anisindione CAS Registry Number: 117-37-3 茴茚二酮

CAS Name: 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione
Additional Names: 2-p-anisyl-1,3-indandione; 2-(p-methoxyphenyl)-1,3-indandioneTrademarks: Miradon (Schering); Unidone (Schering)
Percen...
Literature References: Prepn: Koelsch, J. Am. Chem. Soc. 58, 1331 (1936); Horeau, Jacques, Bull. Soc. Chim. Fr. 1948, 53; Sperber, US 2899358 (1959 to Schering).

tert-Butylbenzene CAS Registry Number: 98-06-6 叔丁基苯

CAS Name: (1,1-Dimethylethyl)benzene
Additional Names: 2-methyl-2-phenylpropane; trimethylphenylmethane; pseudobutylbenzene
Percent Composition: C 89.49%, H 10.51%
Literature References: Prepn: Konowalow, Bull. Soc. Chim. [3] 16, 865 (1896); Shoesmith, Mackie, J. Chem. Soc. 1928, 2336; Meyer, Bernhauer, Monatsh. Chem. 53, 727 (1929); Wilt, Abegg, J. Org. Chem. 33, 923 (1968). See also Groose, Ipatieff, J. Am. Chem. Soc. 57, 2415 (1935); Ipatieff, Pines, ibid. 58, 1056 (1936).

Salazosulfadimidine CAS Registry Number: 2315-08-4 柳氮磺嘧啶

CAS Name: 5-[[4-[[(4,6-Dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]azo]-2-hydroxybenzoic acid
Additional Names: 5-[p-[(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]phenylazo]salicylic acid; 4'-(4,6-di...
Literature References: Prepn: Korkuczanski, Przem. Chem. 37, 162 (1958), C.A. 52, 13727 (1958); Malatesta, Lotti, Ann. Chim. (Rome) 50, 114 (1960), C.A. 56, 8613g (1962).

Nitroxoline CAS Registry Number: 4008-48-4 5-硝基-8-羟基喹啉

CAS Name: 5-Nitro-8-quinolinol
Additional Names: 5-nitro-8-hydroxyquinoline
Trademarks: Enterocol; Nibiol; Noxibiol; Uritrol; Urocoli
Percent Composition: C 56.84%, H 3.18%, N 14.73%, O 2...
Literature References: Prepn: Kostanecki, Ber. 24, 154 (1891); Petrow, Sturgeon, J. Chem. Soc. 1954, 570; Pratt, Duke, J. Am. Chem. Soc. 82, 1155 (1960). In vitro antibacterial and antifungal activity: A. Desvignes, P. Leguen, Ann. Pharm. Fr. 21, 803 (1963); M. Medic-Saric et al., Chemotherapy 26, 263 (1980). Toxicological study: O. Angelova et al., Adv. Antimicrob. Antineoplast. Chemother., Proc. 7th Int. Congr. Chemother. 1, 507 (1972). Clinical pharmacokinetics: A. Mrhar et al., Int. J. Clin. Pharmacol. Biopharm. 17, 476 (1979). HPLC determn in plasma and urine: R. H. A. Sorel et al., J. Chromatogr. 222, 241 (1981). Clinical evaluation in urinary tract infections: M. R. Jacobs et al., S. Afr. Med. J. 54, 959 (1978); B. Cancet, A. Amgar, Pathol. Biol. 35, 879 (1987).

Phenopyrazone CAS Registry Number: 3426-01-5 非诺吡酮

CAS Name: 1,4-Diphenyl-3,5-pyrazolidinedione
Additional Names: 1,4-diphenyl-3,5-dioxopyrazolidine
Percent Composition: C 71.42%, H 4.79%, N 11.10%, O 12.68%
Literature References: Prepn: Kraft, US 2909465 (1959 to Knoll).

Tiomesterone CAS Registry Number: 2205-73-4 硫甲睾酮

CAS Name: (1a,7a,17b)-1,7-Bis(acetylthio)-17-hydroxy-17-methylandrost-4-en-3-one
Additional Names: 17b-hydroxy-1a,7a-dimercapto-17-methylandrost-4-en-3-one 1,7-diacetate; 1a,7a-bis(acetylthio)-...
Literature References: Prepn: Krämer, Ber. 96, 2803 (1963); Brueckner et al., US 3087942 (1963 to E. Merck).

Aluminum Benzoate CAS Registry Number: 555-32-8 苯甲酸铝

Percent Composition: C 64.62%, H 3.87%, Al 6.91%, O 24.59%
Literature References: Prepn: Kränzlein et al., DE 569946 (1933 to I. G. Farbenind.); Frdl. 19, 597.

Carbiphene CAS Registry Number: 15687-16-8 alpha-乙氧基-N-甲基-N-[2-[甲基(苯乙基)氨基]乙基]-alpha-苯基苯乙酰胺

CAS Name: a-Ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-a-phenylbenzeneacetamide
Additional Names: 2-ethoxy-N-methyl-N-[2-(methylphenethylamino)ethyl]-2,2-diphenylacetamide; etomide...
Literature References: Prepn: Krapcho, Turk, J. Med. Chem. 6, 547 (1963).

Triethylenediamine CAS Registry Number: 280-57-9 三乙烯二胺

CAS Name: 1,4-Diazabicyclo[2.2.2]octane
Trademarks: Dabco (Air Prods.)
Percent Composition: C 64.25%, H 10.78%, N 24.97%
Literature References: Prepn: Krause et al., GB 871754 (1958 to Houdry Process).

N 4 - b - D -Glucosylsulfanilamide CAS Registry Number: 53274-53-6

CAS Name: 4-(b-D-Glucopyranosylamino)benzenesulfonamide
Additional Names: N4-b-d-glucosidosulfanilamide; sulfanilamide-d-glucoside; N-p-sulfamylphenyl-D-glucosylamine
Trademarks: Prontogluca...
Literature References: Prepn: Kuhn, Birkofer, Ber. 71, 621 (1938); Bognár, Nánási, J. Chem. Soc. 1953, 1703; Bognár et al., Magy. Kem. Foly. 62, 271 (1956), C.A. 54, 4399g (1960). Structure: Braun et al., J. Org. Chem. 7, 19 (1942).