其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Alverine CAS Registry Number: 150-59-4 阿尔维林

CAS Name: N-Ethyl-N-(3-phenylpropyl)benzenepropanamine
Additional Names: N-ethyl-3,3'-diphenyldipropylamine; bis(g-phenylpropyl)ethylamine; di(phenylpropyl)ethylamine
Percent Composition: C ...
Literature References: Prepn: Külz et al., Ber. 72, 2165 (1939); Stühner, Elbrächter, Arch. Pharm. 287, 139 (1954). Physical properties: E. F. Salim, W. R. Ebert, J. Pharm. Sci. 56, 1162 (1967). Clinical trial in irritable bowel syndrome: G. J. Tudor, Br. J. Clin. Pract. 40, 276 (1985).

Isovaline CAS Registry Number: 595-39-1 2-氨基-2-甲基丁酸

Additional Names: DL-2-Amino-2-methylbutyric acid; a-amino-a-methylbutyric acid
Percent Composition: C 51.26%, H 9.46%, N 11.96%, O 27.31%
Literature References: Prepn: Kurono, Biochem. Z. 134, 427 (1922); Levene, Steiger, J. Biol. Chem. 76, 299 (1928); Bucherer, Steiner, J. Prakt. Chem. 141, 5 (1934); Upham, Dermer, J. Org. Chem. 22, 799 (1957). Optical enantiomorphs: Ehrlich, Wendel, Biochem. Z. 8, 438 (1908); Fischer, von Gravenitz, Ann. 406, 5 (1914); Baker et al., J. Am. Chem. Soc. 74, 4701 (1952); Greenstein et al., J. Biol. Chem. 204, 307 (1953).

Butibufen CAS Registry Number: 55837-18-8 布比布芬

CAS Name: a-Ethyl-4-(2-methylpropyl)benzeneacetic acid
Additional Names: 2-(4-isobutylphenyl)butyric acid
Trademarks: Butilopan (Juste)
Percent Composition: C 76.32%, H 9.15%, O 14.52%
Literature References: Prepn: L. Aparicio et al., DE 2505813; eidem, US 4031243 (1976, 1977 both to Juste); J. M. Carretero et al., Eur. J. Med. Chem. 13, 77 (1978). Pharmacology: L. Aparicio, Arch. Int. Pharmacodyn. Ther. 227, 130 (1977). Pharmacokinetics: R. Revilla De Granda et al., An. R. Acad. Farm. 43, 419 (1977), C.A. 88, 83349 (1978). HPLC determination: L. González Tavares et al., Arzneim.-Forsch. 42, 818 (1992).

Thioglycerol CAS Registry Number: 96-27-5 1-硫代甘油

CAS Name: 3-Mercapto-1,2-propanediol
Additional Names: a-monothioglycerol; thioglycerin
Percent Composition: C 33.31%, H 7.46%, O 29.58%, S 29.65%
Literature References: Prepn: L. Carius, Ann. 124, 221 (1862); B. Sjöberg, Ber. 75, 13 (1942). Use in fast atom bombardment MS: C. Dass, J. Mass Spectrom. 31, 77 (1996); as antioxidant in cell culture media: M. Brielmeier et al., Nucleic Acids Res. 26, 2082 (1998).

Ecabet CAS Registry Number: 33159-27-2 (1R,4aS,10aR)-7-异丙基-1,4a-二甲基-6-磺基-1,2,3,4,4a,9,10,10a-八氢菲-1-羧酸

CAS Name: (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-1-phenanthrenecarboxylic acid
Additional Names: dehydro-6-sulfoabietic acid; 12-sulfodehydroabietic...
Literature References: Prepn: L. F. Fieser, W. P. Campbell, J. Am. Chem. Soc. 60, 2631 (1938); H. Wada et al., Chem. Pharm. Bull. 33, 1472 (1985). Metabolism in animals: Y. Ito et al., J. Pharmacobio-Dyn. 14, 533 (1991). Efficacy in healing expt ulcers in rats: Y. Onoda et al., Arzneim.-Forsch. 41, 546 (1991). Gastroprotective effects in rats in comparison with sucralfate, q.v.: M. Kinoshita et al., Dig. Dis. Sci. 40, 661 (1995). Bactericidal activity against Helicobacter pylori: K. Shibata et al., Antimicrob. Agents Chemother. 39, 1295 (1995).

Butyl Cellosolve® (Union Carbide) CAS Registry Number: 111-76-2 乙二醇丁醚

CAS Name: 2-Butoxyethanol
Additional Names: ethylene glycol monobutyl ether
Percent Composition: C 60.98%, H 11.94%, O 27.08%
Literature References: Prepn: L. H. Cretcher, W. H. Pittenger, J. Am. Chem. Soc. 46, 1503 (1924); W. W. Carlson, US 2448767 (1948 to Mellon Inst. Ind. Res.); R. Riemschneider, P. Gross, Monatsh. Chem. 90, 783 (1959). Toxicity: H. F. Smyth et al., J. Ind. Hyg. Toxicol. 23, 259 (1941); C. P. Carpenter et al., Arch. Ind. Health 14, 114 (1956). Series of articles on toxicology: Environ. Health Perspect. 57, 1-275 (1984). Review of toxicology and human exposure: Toxicological Profile for 2-Butoxyethanol and 2-Butoxyethanol Acetate (PB99-102527, 1998) 404 pp.

Diphenylpyraline CAS Registry Number: 147-20-6 4-(苯甲酰氧基)-1-甲基哌啶

CAS Name: 4-(Diphenylmethoxy)-1-methylpiperidine
Additional Names: diphenylpyrilene; 4-benzhydryloxy-N-methylpiperidine; 1-methyl-4-piperidyl benzhydryl ether; 1-methyl-4-hydroxypiperidine benz...
Literature References: Prepn: L. H. Knox, R. Kapp, US 2479843 (1949 to Nopco). Pharmacokinetics: G. Graham, A. G. Bolt, J. Pharmacokinet. Biopharm. 2, 191 (1974). Clinical trial in allergic rhinitis: H. Puhakka et al., J. Int. Med. Res. 5, 37 (1977). GC determn in blood and urine: H. Hattori et al., J. Chromatogr. 581, 213 (1992).

Cinolazepam CAS Registry Number: 75696-02-5 西诺西泮

CAS Name: 7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-3-hydroxy-2-oxo-1H-1,4-benzodiazepine-1-propanenitrile
Additional Names: 1-(2-cyanoethyl)-7-chloro-3-hydroxy-5-(2'-fluorophenyl)-1,3-dihydro-2H...
Literature References: Prepn: L. H. Schlager, DE 2950235; idem, US 4388313 (1980, 1983 both to Gerot). Benzodiazepine receptor affinity: W. Sieghart, A. Schuster, Biochem. Pharmacol. 33, 4033 (1984). Polarographic and HPLC analyses: H. Oelschläger et al., Arch. Pharm. 325, 65 (1992). Clinical pharmacokinetics: J. Grünberger et al., Adv. Ther. 4, 84 (1987). Clinical evaluation in insomnia: B. Saletu et al., Int. J. Clin. Pharmacol. Res. 7, 407 (1987).

Methyl tert-Butyl Ether CAS Registry Number: 1634-04-4 甲基叔丁基醚

CAS Name: 2-Methoxy-2-methylpropane
Additional Names: tert-butyl methyl ether; MTBE
Percent Composition: C 68.13%, H 13.72%, O 18.15%
Literature References: Prepn: L. Henry, Rec. Trav. Chim. 23, 324 (1904); from methanol and t-butyl alcohol: J. F. Norris, G. W. Rigby, J. Am. Chem. Soc. 54, 2088 (1932); from methanol and isobutylene: K. R. Edlund, T. W. Evans, US 1968601 (1934 to Shell); eidem, Ind. Eng. Chem. 28, 1186 (1936); R. D. Morin, A. E. Bearse, ibid. 43, 1596 (1951); from t-butyl alcohol and diazomethane: M. Neeman et al., Tetrahedron 6, 36 (1959). Use as chromatographic eluent: C. J. Little et al., J. Chromatogr. 169, 381 (1979). Experimental use to dissolve cholesterol gallstones in vivo: M. J. Allen et al., Gastroenterology 88, 122 (1985); eidem, N. Engl. J. Med. 312, 217 (1985). Method for therapeutic use in dissolving cholesterol calculi: J. L. Thistle, M. J. Allen, US 4758596 (1988 to Research Corp.). Acute toxicity: D. F. Marsh, C. D. Leake, Anesthesiology 11, 455 (1950). Reviews of toxicity: R. von Burg, J. Appl. Toxicol. 12, 73-74 (1992); E. Reese, R. D. Kimbrough, Environ. Health Perspect. 101, Suppl. 6, 115-131 (1993); M. G. Costantini, ibid. 151-160; and human exposure: Toxicological Profile for Methyl tert-butyl ether (PB97-121016, 1996) 268 pp.

N-Nitrosomorpholine CAS Registry Number: 59-89-2 N-亚硝基吗啉

CAS Name: 4-Nitrosomorpholine
Additional Names: NMOR
Percent Composition: C 41.37%, H 6.94%, N 24.12%, O 27.56%
Literature References: Prepn: L. Knorr, Ann. 301, 1 (1898); F. Chapman, J. Chem. Soc. 1949, 1631; G. Oláh et al., Ber. 89, 2374 (1956). Metabolism: B. W. Stewart, P. N. Magee, Biochem. J. 126, 21P (1972). Carcinogenicity studies: H. Druckrey et al., Naturwissenschaften 48, 134 (1961); P. Bannasch, H.-A. Müller, Arzneim.-Forsch. 14, 805 (1964); IARC Monographs 17, 263 (1978).