其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Tinofedrine CAS Registry Number: 66788-41-8 替诺非君

CAS Name: a-[1-[(3,3-Di-3-thienyl-2-propenyl)amino]ethyl]benzenemethanol
Additional Names: a-[1-[(3,3-di-3-thienylallyl)amino]ethyl]benzyl alcohol
Percent Composition: C 67.57%, H 5.95%, N 3...
Literature References: Prepn: K. Thiele, K. Posselt, DE 1921453 (1970 to Degussa), C.A. 74, 76320c (1971); K. Posselt, H. Offermanns, DE 2150977 corresp to US 3767675 (1972, 1973 both to Degussa); K. Thiele et al., Arzneim.-Forsch. 28, 2047 (1978). Absolute configuration determined by circular dichroism: J. Engle et al., Chem. Ztg. 105, 85 (1981). Series of articles on pharmacology, hemodynamics, pharmacokinetics, metabolism: Arzneim.-Forsch. 28, 1335-1367 (1978). Synthesis of radioactive tinofedrine: A. Saus, K. Posselt, ibid. 30, 917 (1980). Spectroscopic study: K. Thiele et al., ibid. 1057. EEG study in geriatric patients: B. Saletu, P. Anderer, ibid. 1218. General effects on heart and blood circulation: F. Stroman, K. Thiemer, ibid. 31, 1892 (1981).

N-Bromosuccinimide CAS Registry Number: 128-08-5 N-溴代丁二酰亚胺

CAS Name: 1-Bromo-2,5-pyrrolidinedione
Additional Names: succinbromimide; NBS
Percent Composition: C 26.99%, H 2.27%, Br 44.89%, N 7.87%, O 17.98%
Literature References: Prepn: K. Ziegler et al., Ann. 551, 109 (1942). In bromination of olefins: eidem, ibid. 80. The method has been extended to other classes of compds by the use of catalysts: H. Schmid, P. Karrer, Helv. Chim. Acta 29, 573 (1946); H. Schmid, ibid. 1144. In oxidation of aldehydes: Y. F. Cheung, Tetrahedron Lett. 1979, 3809. Review of uses: C. Djerassi, Chem. Rev. 43, 271-317 (1948); R. Filler, ibid. 63, 21-43 (1963); J. S. Pizey, Synthetic Reagents vol. 2 (John Wiley, New York, 1974) pp 1-63.

Bamipine CAS Registry Number: 4945-47-5 苄哌苯胺

CAS Name: 1-Methyl-N-phenyl-N-(phenylmethyl)-4-piperidinamine
Additional Names: 4-N-benzylanilino-1-methylpiperidine; N-phenyl-N-benzyl-4-amino-1-methylpiperidine
Percent Composition: C 81.3...
Literature References: Prepn: Kallischnigg, US 2683714 (1954 to Knoll). Toxicity studies: Hanna, Toxicol. Appl. Pharmacol. 3, 393 (1961). Determn in pharmaceutical preparations: M. H. Barary, Pharmazie 39, 706 (1984).

Difenamizole CAS Registry Number: 20170-20-1 二苯米唑

CAS Name: 2-(Dimethylamino)-N-(1,3-diphenyl-1H-pyrazol-5-yl)propanamide
Additional Names: 1,3-diphenyl-5-(2-dimethylaminopropionamido)pyrazoleTrademarks: Pasalin (Takeda)
Percent Composition...
Literature References: Prepn: Kameyama, Niwa, JP 68 6621 (1968 to Takeda), C.A. 69, 106704x (1968). Physicochemical properties and stability: Uda, Yashiki, Takeda Kenkyushoho 29, 42 (1970), C.A. 73, 28847n (1970). Pharmacology: Fukuda et al., ibid. 30, 389 (1971); Saji et al., ibid. 406; Nagawa et al., ibid. 427, C.A. 76, 108025v, 108021r, 108023t (1972), resp. Toxicity studies: Tanaka et al., Oyo Yakuri 6, 279 (1972). Mechanism of action studies: Yasuhara et al., ibid. 313. Acute toxicity: M. Hayashi et al., Gifu Daigaku Igakubu Kiyo 20, 360 (1972), C.A. 78, 92505e (1973). Review: Jpn. Med. Gaz. 10(11), 12 (1973).

N-Methylphenazonium Methosulfate CAS Registry Number: 299-11-6 5-甲基吩嗪硫酸甲酯

CAS Name: 5-Methylphenazinium methyl sulfate
Additional Names: phenazine methosulfate
Percent Composition: C 54.89%, H 4.61%, N 9.14%, O 20.89%, S 10.47%
Literature References: Prepn: Kehrmann, Ber. 46, 341 (1913); Hillemann, ibid. 71, 34 (1938); Dickens, McIlwain, Biochem. J. 32, 1615 (1938). Mutagenicity study: S. Venitt, C. Crofton-Sleigh, Mutat. Res. 68, 107 (1979).

Ammonium Bimalate CAS Registry Number: 5972-71-4 丁二酸,2-羟基-,铵盐(1:1)

CAS Name: Hydroxybutanedioic acid monoammonium salt
Additional Names: l-malic acid monoammonium salt; ammonium acid malate
Percent Composition: C 31.79%, H 6.00%, N 9.27%, O 52.94%
Literature References: Prepn: Kendrick, Ber. 30, 1749 (1897); Holmberg, ibid. 61, 1885 (1928).

Clorophene CAS Registry Number: 120-32-1 4-氯-2-苄基苯酚

CAS Name: 4-Chloro-2-(phenylmethyl)phenol
Additional Names: 4-chloro-a-phenyl-o-cresol; 2-benzyl-4-chlorophenol; 5-chloro-2-hydroxydiphenylmethane; o-benzyl-p-chlorophenol
Trademarks: Septip...
Literature References: Prepn: Klarmann et al., J. Am. Chem. Soc. 54, 3315 (1932); Klarmann, Gate, US 1967825 (to Lehn Fink); from Na or K phenoxide and benzyl chloride followed by chlorination of the resulting o-benzylphenol: Kaiser, DE 703955 (1941 to Deutsche Hydrierwerke).

Choline Dihydrogen Citrate CAS Registry Number: 77-91-8 柠檬酸二氢胆碱

Additional Names: (2-Hydroxyethyl)trimethylammonium citrate
Trademarks: Chothyn (Tilden-Yates); Cirrocolina; Citracholine
Percent Composition: C 44.74%, H 7.17%, N 4.74%, O 43.35%
Literature References: Prepn: Klein et al., US 2870198 (1959).

Phenamacide Hydrochloride CAS Registry Number: 31031-74-0 2-氨基-2-苯基乙酸异戊酯盐酸盐

CAS Name: a-Aminobenzeneacetic acid 3-methylbutyl ester hydrochloride
Additional Names: 2-phenylglycine isopentyl ester hydrochloride; isopentyl 2-phenylglycinate hydrochloride; phenylaminoacet...
Literature References: Prepn: Klosa, Arch. Pharm. 285, 332 (1952). Pharmacology: Schultz et al., Pharmazie 25, 560 (1970).

Ammonium Pentachlorozincate CAS Registry Number: 14639-98-6

Additional Names: Zinc ammonium chloride
Percent Composition: Cl 59.73%, H 4.08%, N 14.16%, Zn 22.04%
Literature References: Prepn: Klug, Alexander, J. Am. Chem. Soc. 66, 1056 (1944).