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Tinofedrine CAS Registry Number: 66788-41-8 替诺非君

CAS Name: a-[1-[(3,3-Di-3-thienyl-2-propenyl)amino]ethyl]benzenemethanol
Additional Names: a-[1-[(3,3-di-3-thienylallyl)amino]ethyl]benzyl alcohol
Percent Composition: C 67.57%, H 5.95%, N 3.94%, O 4.50%, S 18.04%

📌 参考资料/链接：
Literature References: Prepn: K. Thiele, K. Posselt, DE 1921453 (1970 to Degussa), C.A. 74, 76320c (1971); K. Posselt, H. Offermanns, DE 2150977 corresp to US 3767675 (1972, 1973 both to Degussa); K. Thiele et al., Arzneim.-Forsch. 28, 2047 (1978). Absolute configuration determined by circular dichroism: J. Engle et al., Chem. Ztg. 105, 85 (1981). Series of articles on pharmacology, hemodynamics, pharmacokinetics, metabolism: Arzneim.-Forsch. 28, 1335-1367 (1978). Synthesis of radioactive tinofedrine: A. Saus, K. Posselt, ibid. 30, 917 (1980). Spectroscopic study: K. Thiele et al., ibid. 1057. EEG study in geriatric patients: B. Saletu, P. Anderer, ibid. 1218. General effects on heart and blood circulation: F. Stroman, K. Thiemer, ibid. 31, 1892 (1981).

📄 详细内容

Derivative Type: Hydrochloride
CAS Registry Number: 50776-39-1Trademarks: Novocebrin (Asta)
Percent Composition: C 61.28%, H 5.66%, N 3.57%, O 4.08%, S 16.36%, Cl 9.04%
Properties: Cryst from isopropanol, mp 226-229° (dec). LD50 in mice, rats (mg/kg): 1890, 6600 orally, 20.15, 14.00 i.v., P. St. Janiak, Drugs Future
4, 286 (1979).
Melting point: mp 226-229° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 1890, 6600 orally, 20.15, 14.00 i.v., P. St. Janiak, Drugs Future
4, 286 (1979)
Therap-Cat: Vasodilator (cerebral).
Keywords: Vasodilator (Cerebral).
Status: This monograph has been retired and is no longer subject to revision or update.
产品链接: 66788-41-8››

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