其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dialifor CAS Registry Number: 10311-84-9 氯亚胺硫磷

CAS Name: Phosphorodithioic acid S-[2-chloro-1-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl] O,O-diethyl ester
Additional Names: phosphorodithioic acid O,O-diethyl ester S-ester with N-(2-chlo...
Literature References: Prepn: Jamison, US 3355353 (1967 to Hercules). Acute toxicity: T. B. Gaines, R. E. Linder, Fundam. Appl. Toxicol. 7, 299 (1986).

Loperamide CAS Registry Number: 53179-11-6 洛哌丁胺

CAS Name: 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutanamide
Additional Names: 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutyramide
Percen...
Literature References: Prepn: Janssen et al., FR 2100711; eidem, US 3714159 (1972, 1973 to Janssen); Stokbroekx et al., J. Med. Chem. 16, 782 (1973). LC-MS/MS determn in plasma: B. Streel et al., J. Chromatogr. B 814, 263 (2005). Series of articles on pharmacology, toxicology, metabolism, and clinical studies: Arzneim.-Forsch. 24, 1640-1665 (1974). Toxicity studies: C. J. E. Niemegeers et al., ibid. 1633, 1636. Review: D. A. Shriver et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 3, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1981) pp 461-476. Comprehensive description: J. Van Rompay, J. E. Carter, Anal. Profiles Drug Subs. 19, 341-365 (1990).

Pimozide CAS Registry Number: 2062-78-4 匹莫齐特

CAS Name: 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Additional Names: 1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone; 1-[4,4-di-...
Literature References: Prepn: Janssen, FR M3695 (1965 to Janssen), C.A. 66, 115709t (1967). Pharmacological studies: Janssen et al., Arzneim.-Forsch. 18, 261, 279, 282 (1968). Metabolism in rats: Soudijn, Wijngaarden, Life Sci. 8, 291 (1969). Clinical experience: Poldinger, Curr. Ther. Res. 13, 23 (1971). Pimozide blocks establishment but not expression of amphetamine-produced environment-specific conditioning: R. J. Beninger, B. L. Hahn, Science 220, 1304 (1983). Use in treatment of acute schizophrenia: B. Shopsin, G. Selzer, Curr. Ther. Res. 21, 755 (1977); in treatment of chronic schizophrenia: F. Kline et al., ibid. 768. In management of Gilles de la Tourette's syndrome: M. S. Ross, H. Moldofsky, Lancet 1, 103 (1977); A. K. Shapiro, E. Shapiro, Am. J. Psychiatry 140, 1235 (1983); eidem, J. Am. Acad. Child Psychiatry 23, 161 (1984).

Azaperone CAS Registry Number: 1649-18-9 阿扎哌隆

CAS Name: 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone
Additional Names: 4'-fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone; 1-[3-(4-fluorobenzoyl)propyl]-4-(2-pyridyl)pi...
Literature References: Prepn: Janssen, US 2979508 (1961). Synthesis of labeled compound: Soudijn, van Wijngaarden, J. Lab. Comp. 4, 159 (1968). Distribution and metabolism studies in rat and pig: Heykants et al., Arzneim.-Forsch. 21, 982, 1263, 1357 (1971). Veterinary clinical studies: Symoens, van den Brande, Vet. Rec. 85, 64 (1969). Crystal structure: M. H. J. Koch et al., Acta Crystallogr. 33B, 1975 (1977).

Fluanisone CAS Registry Number: 1480-19-9 氟阿尼酮

CAS Name: 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-1-butanone
Additional Names: 4'-fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]butyrophenone; haloanisoneTrademarks: Sedalande (J...
Literature References: Prepn: Janssen, US 2997472 (1961). Determn in human plasma: M. P. Quaglio, A. M. Bellini, Farmaco Ed. Prat. 36, 204 (1981). Comparison between biochemical and behavioral effects: G. B. Fregnan, R. Porta, Arzneim.-Forsch. 31, 70 (1981). Toxicity study: C. Cascio et al., Farmaco Ed. Sci. 35, 605 (1980).

Prozapine CAS Registry Number: 3426-08-2 普罗扎平

CAS Name: 1-(3,3-Diphenylpropyl)hexahydro-1H-azepine
Additional Names: 1-(3,3-diphenylpropyl)hexamethylenimine; 1,1-diphenyl-3-hexamethyleneiminopropane; hexadiphane
Percent Composition: C 8...
Literature References: Prepn: Janssen, de Jongh, US 2881165 (1959 to N. V. Nederland. Comb. Chem. Ind.).

Salicylhydroxamic Acid CAS Registry Number: 89-73-6 水杨羟肟酸

CAS Name: N,2-Dihydroxybenzamide
Additional Names: 2-hydroxybenzhydroxamic acid
Percent Composition: C 54.90%, H 4.61%, N 9.15%, O 31.34%
Literature References: Prepn: Jeanrenaud, Ber. 22, 1272 (1889); Urbanski, Nature 166, 267 (1950). Trypanocidal activity: F. Opperdoes et al., Exp. Parasitol. 40, 198 (1976); A. B. Clarkson, F. H. Brohn, Science 194, 204 (1976); A. J. Barnicoat et al., Experientia 37, 1291 (1981).

Potassium Hexafluoromanganate(IV) CAS Registry Number: 16962-31-5

Additional Names: Potassium manganese hexafluoride; potassium hexafluomanganite
Percent Composition: F 46.13%, K 31.64%, Mn 22.23%
Literature References: Prepn: Jenssen, Bandte, Angew. Chem. 65, 304 (1953).

Phenactropinium Chloride CAS Registry Number: 3784-89-2 芬托氯铵

CAS Name: 3-[(Hydroxyphenylacetyl)oxy]-8-methyl-8-(2-oxo-2-phenylethyl)-8-azoniabicyclo[3.2.1]octane chloride
Additional Names: 8-benzoylmethyl-3a-hydroxy-1aH,5aH-tropanium chloride mandelate; ...
Literature References: Prepn: Johnston, Spencer, US 2828312 (1958 to T. H. Smith). Ganglionic blocking agent.

Dyphylline CAS Registry Number: 479-18-5 二羟丙茶碱

CAS Name: 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(2,3-dihydroxypropyl)theophylline; (1,2-dihydroxy-3-propyl)theophylline; glyphylline; glyfylli...
Literature References: Prepn: Jones, Maney, US 2575344 (1951 to State Univ. of Iowa); Roth, Arch. Pharm. 292, 234 (1959). Toxicity data: R. A. Al'tshuler, Med. Prom. SSSR 16, 57 (1962), C.A. 61, 6230g (1964).