其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Buflomedil CAS Registry Number: 55837-25-7 丁洛地尔

CAS Name: 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
Additional Names: 2',4',6'-trimethoxy-4-(1-pyrrolidinyl)butyrophenone; (2,4,6-trimethoxyphenyl)-(3-pyrrolidinopropyl) ketone Literature References: Prepn: L. Lafon, DE 2122144; idem, US 3895030 (both 1971 to Orsymonde). Pharmacology: J. Duteil et al., Therapie 30, 207 (1975); C. Debray et al., ibid. 259. HPLC determn: J. A. Badmin et al., J. Chromatogr. 172, 319 (1979). Clinical pharmacokinetics: U. Gundert-Remy et al., Eur. J. Clin. Pharmacol. 20, 459 (1981). Comparative safety and efficacy study: G. Rosas et al., Angiology 32, 291 (1981). Review of pharmacology and therapeutic effects: S. P. Clissold et al., Drugs 33, 430-460 (1987).

Iprindole CAS Registry Number: 5560-72-5 伊普吲哚

CAS Name: 6,7,8,9,10,11-Hexahydro-N,N-dimethyl-5H-cyclooct[b]indole-5-propanamine
Additional Names: 5-[3-(dimethylamino)propyl]-6,7,8,9,10,11-hexahydro-5H-cyclooct[b]indole; 1-(3-dimethylaminop...
Literature References: Prepn: L. M. Rice, M. E. Freed, BE 623933; eidem, US 3282942 (1963, 1966, both to Am. Home Prods.); Rice et al., J. Med. Chem. 7, 313 (1964). Pharmacology: Gluckman, Baum, Psychopharmacologia 15, 169 (1969); Baum et al., Eur. J. Pharmacol. 13, 287 (1971). Mechanism of action: Miller et al., Experientia 26, 863 (1970); Lemberger et al., Biochem. Pharmacol. 19, 3021 (1970). Freeman, Sulser, J. Pharmacol. Exp. Ther. 183, 307 (1972).

Embramine CAS Registry Number: 3565-72-8 思布拉敏

CAS Name: 2-[1-(4-Bromophenyl)-1-phenylethoxy]-N,N-dimethylethanamine
Additional Names: 2-[(p-bromo-a-methyl-a-phenylbenzyl)oxy]-N,N-dimethylethylamine; [2-(1-p-bromophenyl-1-phenylethoxy)ethyl...
Literature References: Prepn: L. Novak, M. Protiva, Collect. Czech. Chem. Commun. 24, 3966 (1959); M. Protiva, L. Novak, DE 1240877 (1967 to SPOFA), C.A. 67, 73338j (1967).

Sodium Nitroprusside CAS Registry Number: 14402-89-2 硝普酸钠

CAS Name: Pentakis(cyano-C)nitrosylferrate(2-) disodium
Additional Names: sodium nitrosylpentacyanoferrate(III); sodium nitroferricyanide; sodium nitroprussiate
Trademarks: Nipruss (Schwarz)...
Literature References: Prepn: L. Playfair, Proc. Roy. Soc. London 5, 846 (1849). Pharmacology: Fernandez et al., Arch. Inst. Farmacol. Exp. Madrid 23, 1-51 (1971). Review: I. H. Tuzel, J. Clin. Pharmacol. 14, 494-503 (1974). Review of pharmacology, toxicology and therapeutic uses: J. H. Tinker, J. D. Michenfelder, Anesthesiology 45, 340 (1976). Comprehensive description: R. Rucki, Anal. Profiles Drug Subs. 6, 487-513 (1977); A. Bult et al., ibid. 15, 781-792 (1986). Clinical trial in critically ill patients with heart failure: U. N. Khot et al., N. Engl. J. Med. 348, 1756 (2003).

Gemcitabine CAS Registry Number: 95058-81-4 吉西他滨

CAS Name: 2'-Deoxy-2',2'-difluorocytidine
Additional Names: 1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose; dFdC; dFdCydTrademarks: Gemzar (Lilly)
Percent Composition...
Literature References: Prepn: L. W. Hertel, GB 2136425; idem, US 4808614 (1984, 1989 both to Lilly); L. W. Hertel et al., J. Org. Chem. 53, 2406 (1988); T. S. Chou et al., Synthesis 1992, 565. Antitumor activity: L. W. Hertel et al., Cancer Res. 50, 4417 (1990). Mode of action study: V. W. T. Ruiz et al., Biochem. Pharmacol. 46, 762 (1993). Clinical pharmacokinetics and toxicity: J. L. Abbruzzese et al., J. Clin. Oncol. 9, 491 (1991). Review of clinical studies: B. Lund et al., Cancer Treat. Rev. 19, 45-55 (1993).

Omoconazole CAS Registry Number: 74512-12-2 1-[(1Z)-1-[2-(4-氯苯氧基)乙氧基]-1-(2,4-二氯苯基)-1-丙烯-2-基]-1H-咪唑

CAS Name: 1-[(1Z)-2-[2-(4-Chlorophenoxy)ethoxy]-2-(2,4-dichlorophenyl)-1-methylethenyl]-1H-imidazole
Additional Names: (Z)-1-[2,4-dichloro-b-[2-(p-chlorophenoxy)ethoxy]-a-methylstyryl]imidazole...
Literature References: Prepn: L. Zirngibl et al., DE 2839388; eidem, US 4210657 (both 1980 to Siegfried); and crystal structure: K. Thiele et al., Helv. Chim. Acta 70, 441 (1987). Stereospecific synthesis: L. Zirngibl, K. Thiele, US 4554356 (1985 to Siegfried). In vitro fungistatic activity: M. Mosse et al., Pathol. Biol. 34, 684 (1986).

Methylparaben CAS Registry Number: 99-76-3 尼泊金甲酯

CAS Name: 4-Hydroxybenzoic acid methyl ester
Additional Names: methyl p-hydroxybenzoate
Trademarks: Nipagin M; Tegosept M; Methyl Chemosept; Methyl Parasept (Tenneco)
Percent Composition:...
Literature References: Prepn: Ladenburg, Fitz, Ann. 141, 247 (1867); Zbarskii, C.A. 33, 93123 (1939). Identification in the vaginal secretions of female dogs in estrus: M. Goodwin et al., Science 203, 559 (1979).

Sesin CAS Registry Number: 94-83-7 2-(2,4-二氯苯氧基)乙基苯甲酸酯

CAS Name: Benzoic acid 2,4-dichlorophenoxyethyl ester
Additional Names: 2-(2,4-dichlorophenoxy)ethanol benzoate; 2,4-dichlorophenoxyethyl benzoate
Percent Composition: C 57.90%, H 3.89%, Cl ...
Literature References: Prepn: Lambrech, US 2765224 (1956 to Union Carbide).

Teflurane CAS Registry Number: 124-72-1 1-溴-1,2,2,2-四氟乙烷

CAS Name: 2-Bromo-1,1,1,2-tetrafluoroethane
Additional Names: 1,1,1,2-tetrafluoro-2-bromoethaneTrademarks: Terflurane
Percent Composition: C 13.28%, H 0.56%, Br 44.16%, F 42.00%
Literature References: Prepn: Larsen, US 2971990 (1961 to Dow). Pharmacology: Black et al., Br. J. Anaesth. 41, 288 (1969).

Hexapropymate CAS Registry Number: 358-52-1 炔丙环己酯

CAS Name: 1-(2-Propynyl)cyclohexanol carbamate
Additional Names: carbamic acid 1-(2-propynyl)cyclohexyl ester; 1-(2-propynyl)cyclohexyl carbamate; 1-carbamoyloxy-1-(2-propynyl)cyclohexane; hexo...
Literature References: Prepn: Lauger et al., Helv. Chim. Acta 42, 2379 (1959); Prost, US 2931828 (1960 to Soc. Belge des Labs. Labaz).