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    • 项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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    其它产品项目整合

  • Tetramethylurea CAS Registry Number: 632-22-4 四甲基脲


    Additional Names: TMU
    Trademarks: Temur
    Percent Composition: C 51.70%, H 10.41%, N 24.12%, O 13.77%
    Literature References: Prepn: Lawson, Croom, J. Org. Chem. 28, 232 (1963). Review of prepn, manuf, properties and use as solvent and as reagent: Lüttringhaus, Dirksen, Angew. Chem. Int. Ed. 3, 260 (1964).

  • Leucinocaine Mesylate CAS Registry Number: 135-44-4 亮氨卡因


    CAS Name: 2-(Diethylamino)-4-methyl-1-pentanol 4-aminobenzoate (ester) monomethanesulfonate (salt)
    Additional Names: 2-diethylamino-4-methylpentyl p-aminobenzoate methanesulfonate; p-aminobenzo...
    Literature References: Prepn: Lebeau, Janot, Traité de Pharmacie Chimique vol. III (Masson et Cie, Paris, 1955-1956) p 1296. Prepn of hydrochloride: Karrer, US 1555217 and see also DE 464484 (1925, 1928 to Chem. Fabrik Flora). Efficacy and toxicity in animals: R. N. Bieter et al., J. Pharmacol. Exp. Ther. 57, 221 (1936).

  • Colpormon CAS Registry Number: 1247-71-8 3,16alpha-二羟基雌甾-1,3,5(10)-三烯-17-酮3,16-二乙酸酯


    CAS Name: (16a)-3,16-Bis(acetyloxy)estra-1,3,5(10)-trien-17-one
    Additional Names: 3,16a-dihydroxyestra-1,3,5(10)-trien-17-one diacetate; 16a-hydroxyestrone diacetate; 3,16a-diacetoxy-D1,3,5-est...
    Literature References: Prepn: Leeds et al., J. Am. Chem. Soc. 76, 2943 (1954); FR M1390 (1962 to Lab. Albert Rolland), C.A. 58, 3484c (1963).

  • Mercaptomerin Sodium CAS Registry Number: 21259-76-7


    CAS Name: (T-4)-[3-[[(3-Carboxylato-2,2,3-trimethylcyclopentyl)carbonyl]amino]-2-methoxypropyl][mercaptoacetato(2-)-O,S]mercurate(2-) disodium
    Additional Names: N-(g-carboxymethylmercaptomercur...
    Literature References: Prepn: Lehman, US 2576349 (1951 to Wyeth); Wendt, Bruce, J. Org. Chem. 23, 1448 (1958); Wendt, US 2834795 (1958 to Am. Home Prod.).

  • Resorantel CAS Registry Number: 20788-07-2 N-(4-溴苯基)-2,6-二羟基苯甲酰胺


    CAS Name: N-(4-Bromophenyl)-2,6-dihydroxybenzamide
    Additional Names: 4'-bromo-g-resorcylanilide; 4'-bromo-2,6-dihydroxybenzanilide; 2,6-dihydroxybenzoic acid 4'-bromoanilide; resorcylamTrademar...
    Literature References: Prepn: LeMaire et al., J. Pharm. Sci. 50, 831 (1961); GB 1124613; H. Ruschig et al., US 3449420 (1968, 1969 to Hoechst). Animal studies: Düwel; Behrens, Matschullat; Pfeiffer, Dtsch. Tieraerztl. Wochenschr. 77, 97-107 (1970); Christ et al., Berl. Muench. Tieraerztl. Wochenschr. 83, 61 (1970).

  • Dichloroxylenol CAS Registry Number: 133-53-9 二氯二甲酚


    CAS Name: 2,4-Dichloro-3,5-dimethylphenol
    Additional Names: 2,4-dichloro-3,5-xylenol; DCMX
    Percent Composition: C 50.29%, H 4.22%, Cl 37.11%, O 8.37%
    Literature References: Prepn: Lesser, Gad, Ber. 56, 963 (1923); Jones, J. Chem. Soc. 1941, 267; Gemmell, Manuf. Chem. 23, 63 (1952).

  • sec-Butyl Bromide CAS Registry Number: 78-76-2 溴代仲丁烷


    CAS Name: 2-Bromobutane
    Additional Names: methylethylbromomethane
    Percent Composition: C 35.06%, H 6.62%, Br 58.32%
    Literature References: Prepn: Levene, Marker, J. Biol. Chem. 91, 405 (1931); Kenyon et al., J. Chem. Soc. 1935, 1080; Skau, McCullough, J. Am. Chem. Soc. 57, 2440 (1935); Colson et al., J. Chem. Soc. 1965, 2364. Prepn of optically pure isomers: Goodwin, Hudson, J. Chem. Soc. B 1968, 1333.

  • Hydracarbazine CAS Registry Number: 3614-47-9 肼卡巴嗪


    CAS Name: 6-Hydrazino-3-pyridazinecarboxamide
    Additional Names: 3-hydrazino-6-carbamoylpyridazine; 3-hydrazinopyridazine-6-carboxamide
    Percent Composition: C 39.21%, H 4.61%, N 45.73%, O 10....
    Literature References: Prepn: Libermann, Rouaix, Bull. Soc. Chim. Fr. 1959, 1793; GB 856409 (1960 to Chimie et Atomistique).

  • Bitoscanate CAS Registry Number: 4044-65-9 对苯二异硫氰酸酯


    CAS Name: 1,4-Diisothiocyanatobenzene
    Additional Names: phenylene-1,4-diisothiocyanate; isothiocyanic acid p-phenylene ester
    Trademarks: Jonit (Hoechst)
    Percent Composition: C 49.98%, H 2...
    Literature References: Prepn: Lieber, Slutkin, J. Org. Chem. 27, 2214 (1962). Prepn and use as anthelmintic: FR M1652 and GB 1001314 (1963, 1965 to Hoechst). Purification: Soeder, Laemmer, DE 1172664 (1964 to Hoechst). Series of articles on clinical studies: Progress in Drug Research vol. 19, E. Jucker, Ed. (Birkhäuser Verlag, Basel and Stuttgart, 1975) pp 2-107.

  • Methylthiouracil CAS Registry Number: 56-04-2 甲硫尿嘧啶


    CAS Name: 2,3-Dihydro-6-methyl-2-thioxo-4(1H)-pyrimidinone
    Additional Names: 6-methyl-2-thiouracil; 4-methyl-2-thiouracil; MTU
    Trademarks: Alkiron; Antibason; Basecil; Basethyrin; Methiacil;...
    Literature References: Prepn: List, Ann. 236, 1 (1886). Toxicity data: Simon, Boll. Soc. Ital. Biol. Sper. 24, 803 (1948).

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