其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Prajmaline CAS Registry Number: 35080-11-6 普拉马林

CAS Name: (17R,21a)-17,21-Dihydroxy-4-propylajmalanium
Additional Names: N4-propylajmalinium; prajmalium; N-propylajmaline
Literature References: Prepn: J. Keck, Z. Naturforsch. 18b, 177 (1963); A. Bonati, E. Bombardelli, Farmaco Ed. Sci. 18, 851 (1963); J. Keck, DE 1154120 (1963 to Thomae); idem, US 3414577 (1968 to Boehringer, Ing.). Pharmacology: R. Koch, Arzneim.-Forsch. 22, 2079 (1972); H. M. Mertens et al., ibid. 23, 642 (1973); K.-W. Diederich, D. Boyksen, ibid. 1302. Toxicology: G. Von Philipsborn, B. Stalder, ibid. 22, 2085 (1972). Pharmacokinetics: A. T. Trompler et al., ibid. 33, 436 (1983). Mechanism of action: H. Langenfeld et al., J. Cardiovasc. Pharmacol. 15, 338 (1990). GC/MS determn in urine: H. H. Maurer, Arch. Toxicol. 64, 218 (1990). Clinical comparison with tocainide, q.v.: B. Schwartzkopff et al., Arzneim.-Forsch. 33, 153 (1983).

Piberaline CAS Registry Number: 39640-15-8 吡贝拉林

CAS Name: 1-(Phenylmethyl)-4-(2-pyridinylcarbonyl)piperazine
Additional Names: 1-benzyl-4-picolinoylpiperazineTrademarks: Trelibet (EGYT)
Percent Composition: C 72.57%, H 6.81%, N 14.94%, O ...
Literature References: Prepn: J. Körösi et al., BE 781494; eidem, US 3865828 (1972, 1975 both to EGYT). Alternate prepns: Z. Budai et al., DE 2828888 C.A. 90, 168643u (1979); eidem, HU 17182 C.A. 92, 215463p (1980) (both 1979 to EGYT); eidem, Acta Chim. Acad. Sci. Hung. 105, 241 (1980), C.A. 94, 192275d (1981). HPLC separation: J. Borda et al., J. Chromatogr. 258, 271 (1983). Effect on avoidance behavior in rats: G. Telegdy et al., Arch. Int. Pharmacodyn. Ther. 266, 50 (1983). Metabolism in animals and humans: K. Magyar, Pol. J. Pharmacol. Pharm. 39, 107 (1987). Mechanism of action study: K. Tekes et al., ibid. 203.

Cyclobendazole CAS Registry Number: 31431-43-3 环苯达唑

CAS Name: [5-(Cyclopropylcarbonyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester
Additional Names: ciclobendazoleTrademarks: Haptocil (Cilag-Chemie)
Percent Composition: C 60.22%, H 5.05%,...
Literature References: Prepn: J. L. Van Gelder et al., DE 2029637; eidem, US 3657267 (1971, 1972 both to Janssen). Synthesis and anthelmintic activity: A. H. M. Raeymaekers et al., Arzneim.-Forsch. 28, 586 (1978). Embryotoxic and antimitotic properties: P. Delatour, Y. Richard, Therapie 31, 505 (1976). Pharmacokinetics: R. R. Brodie et al., Arzneim.-Forsch. 27, 593 (1977). Biotransformation: B. C. Mayo et al., Drug Metab. Dispos. 6, 518 (1978). Clinical evaluation: A. Degrémont, E. Stahel, Schweiz. Med. Wochenschr. 108, 1430 (1978).

Isocyanic Acid CAS Registry Number: 75-13-8 异氰酸酯

Additional Names: Carbimide
Percent Composition: C 27.92%, H 2.34%, N 32.56%, O 37.19%
Literature References: Prepn: J. Liebig, F. Wöhler, Ann. 39, 29 (1846); Steyermark, J. Org. Chem. 28, 586 (1963); R. Vorhoeve, L. E. Trimble, Science 202, 525 (1978). Crystal structure: Von Dohlen, Carpenter, Acta Crystallogr. 8, 646 (1955). Review of prepn and properties: D. J. Belson, A. N. Strachan, Chem. Soc. Rev. 11, 41-56 (1982). See also Cyanic Acid.

Polythiazide CAS Registry Number: 346-18-9 泊利噻嗪

CAS Name: 6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 2-methyl-3-(b,b,b-trifluoroethylthiomethyl)-...
Literature References: Prepn: J. M. McManus, US 3009911 (1961 to Pfizer). Comprehensive description: T. Negendra Varo Prasad, Anal. Profiles Drug Subs. 20, 665-692 (1991).

Picilorex CAS Registry Number: 62510-56-9 匹西雷司

CAS Name: 3-(4-Chlorophenyl)-5-cyclopropyl-2-methylpyrrolidinePercent Composition: C 71.33%, H 7.70%, Cl 15.04%, N 5.94%
Literature References: Prepn: J. M. Teulon, DE 2446317; idem, US 4005103 (1975, 1977 both to Hexachemie). Anorexic activity in animals: G. Dumeur et al., Br. J. Pharmacol. 58, 437 (1976).

Cupric Bisglycinate CAS Registry Number: 13479-54-4 甘氨酸铜

CAS Name: Bis(glycinato-kN,kO)copper
Additional Names: cupric aminoacetate; glycocoll-copper
Trademarks: Copper Chelazome (Albion)
Percent Composition: C 22.70%, H 3.81%, Cu 30.02%, N 13....
Literature References: Prepn: J. Mauthner, W. Suida, Monatsh. Chem. 11, 373 (1890); and characterization: H. Ley, Z. Elektrochem. 10, 954 (1904); and isomerization study: K. Tomita, Bull. Chem. Soc. Jpn. 34, 280 (1961). Thermodynamics of complex formation: K. P. Anderson et al., Inorg. Chem. 5, 2106 (1966). Kinetics of complex formation: A. F. Pearlmutter, J. Stuehr, J. Am. Chem. Soc. 90, 858 (1968). Clinical evaluation in maintenance of bone mineral density: J. Eaton-Evans et al., J. Trace Elem. Exp. Med. 9, 87 (1996).

Pyrrobutamine CAS Registry Number: 91-82-7 吡咯他敏

CAS Name: 1-[4-(4-Chlorophenyl)-3-phenyl-2-butenyl]pyrrolidine
Additional Names: 1-[g-p-(chlorobenzyl)cinnamyl]pyrrolidine; 1-p-chlorophenyl-2-phenyl-4-pyrrolidyl-2-butene
Trademarks: Pyroni...
Literature References: Prepn: J. Mills, US 2655509 (1953 to Eli Lilly). Pharmacology and toxicity: H. M. Lee et al., Proc. Soc. Exp. Biol. Med. 80, 458 (1952). Pharmacology and physical properties: N. G. Lordi, J. E. Christian, J. Am. Pharm. Assoc. 45, 300 (1956). Structure-activity and stereochemical study: A. F. Casy, R. R. Ison, J. Pharm. Pharmacol. 22, 270 (1970). GC-MS determn in urine: H. Maurer, K. Pfleger, J. Chromatogr. 430, 31 (1988).

Hydroxystilbamidine CAS Registry Number: 495-99-8 羟芪巴脒

CAS Name: 4-[2-[4-(Aminoiminomethyl)phenyl]ethenyl]-3-hydroxybenzenecarboximidamide
Additional Names: 2-hydroxy-4,4'-stilbenedicarboxamidine; 2-hydroxy-4,4'-diamidinostilbene; 2-hydroxy-4,4'-di...
Literature References: Prepn: J. N. Ashley, J. O. Harris, J. Chem. Soc. 1946, 567; A. J. Ewins et al., GB 574486; A. J. Ewins, US 2510047 (1946, 1950 both to May Baker). Organ and tissue distribution in animals: I. Snapper et al., Cancer 4, 1246 (1951). Pharmacology and antiprotozoal activity: I. Snapper et al., Trans. N.Y. Acad. Sci. 14, 269 (1952). Probe for studying nucleic acid conformation: B. Festy, C.R. Seances Acad. Sci. Ser. D 266, 1433 (1968); B. Festy, M. Daune, Biochemistry 12, 4827 (1973); B. Festy et al., Biochim. Biophys. Acta 407, 24 (1975). Crystal structure: C. Courseille et al., C.R. Seances Acad. Sci. Ser. C 274, 1921 (1972). Use as a fluorochrome for selective staining of nuclei: L. B. Murgatroyd, Histochemistry 74, 107 (1982). Review: B. Festy in Antibiotics vol. 5, pt. 2, F. E. Hahn, Ed. (Springer-Verlag, New York, 1979) pp 223-235.

Bufencarb CAS Registry Number: 8065-36-9 合杀威乳剂

CAS Name: 3-(1-Ethylpropyl)phenol methylcarbamate mixture with 3-(1-methylbutyl)phenyl methylcarbamate (1:3)
Additional Names: metalkamateTrademarks: Bux (Chevron)
Percent Composition: C 70....
Literature References: Prepn: J. N. Ospenson et al., US 3062864; G. K. Kohn et al., US 3062867 (1962 both to Calif. Res. Corp.). Soil persistence and metabolism: B. V. Tucker, D. E. Pack, J. Agric. Food Chem. 20, 412 (1972). Field trial: T. M. Hills et al., J. Econ. Entomol. 65, 1697 (1972). Acute toxicity: T. B. Gaines, R. E. Linder, Fundam. Appl. Toxicol. 7, 299 (1986). GC/MS determn in liver: R. S. Bakowski et al., J. AOAC Int. 77, 1568 (1994). Review of properties and residue analysis: B. Tucker, Anal. Methods Pestic. Plant Growth Regul. 7, 179-185 (1973).