Polythiazide CAS Registry Number: 346-18-9 泊利噻嗪
CAS Name: 6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 2-methyl-3-(b,b,b-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-3,4-dihydro-2-methyl-7-sulphamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide
Trademarks: Drenusil (Pfizer); Nephril (Pfizer); Renese (Pfizer)
Percent Composition: C 30.03%, H 2.98%, Cl 8.06%, F 12.96%, N 9.55%, O 14.55%, S 21.87%
📌 参考资料/链接：
Literature References: Prepn: J. M. McManus, US 3009911 (1961 to Pfizer). Comprehensive description: T. Negendra Varo Prasad, Anal. Profiles Drug Subs. 20, 665-692 (1991).
📄 详细内容
Properties: Crystals from isopropanol, mp 202.5°. Sol in methanol and acetone. Practically insol in water and chloroform. Sol in aq solns made alkaline with carbonates or hydroxides of the alkali metals. Rate of decompn increases with increase in pH.
Melting point: mp 202.5°
Therap-Cat: Diuretic, antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs.
产品链接: 346-18-9››