Properties: Oily liquid, bp0.3 190-195°. On standing gives crystals, mp 48-49°. d25 1.1052. uv max (95% ethanol): 360, 243 nm (a 112, 9500), (c = 0.538, 0.00538 mg/ml).
Melting point: mp 48-49°
Boiling point: bp0.3 190-195°
Absorption maximum: uv max (95% ethanol): 360, 243 nm (a 112, 9500), (c = 0.538, 0.00538 mg/ml)
Density: d25 1.1052
Derivative Type: Diphosphate
CAS Registry Number: 135-31-9
Percent Composition: C 47.30%, H 5.56%, Cl 6.98%, N 2.76%, O 25.20%, P 12.20%
Properties: Crystals from alcohol + ether, mp 129.5-130°. pKa1 8.77, pka2 5.23. Sol in warm water to the extent of 10%. Soly in alcohol at 25° about 5%. Soly at pH 7.4 (37.5°): 0.00087 M/l. Practically insol in chloroform, ether. LD50 in mice, guinea pigs (mg/kg): 1270 ±156, 1241 ±165 s.c.; 836.8 ±95, 625.6 ±41.9 i.m.; 1116 ±73, 992.6 ±107 orally; in mice (mg/kg): 53.53 ±1.61 i.v. (Lee).
Melting point: mp 129.5-130°
pKa: pKa1 8.77, pka2 5.23
Toxicity data: LD50 in mice, guinea pigs (mg/kg): 1270 ±156, 1241 ±165 s.c.; 836.8 ±95, 625.6 ±41.9 i.m.; 1116 ±73, 992.6 ±107 orally; in mice (mg/kg): 53.53 ±1.61 i.v. (Lee)
Derivative Type: Hydrochloride
Percent Composition: C 68.97%, H 6.66%, Cl 20.36%, N 4.02%
Properties: Crystals from alcohol + ether, mp 227-228°.
Melting point: mp 227-228°
Derivative Type: Hydrobromide
Percent Composition: C 61.16%, H 5.90%, Cl 9.03%, N 3.57%, Br 20.34%
Properties: Crystals from alcohol + ether, mp 228-229°.
Melting point: mp 228-229°
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Alkylamine Derivatives.
产品链接: 91-82-7››