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Acepromazine CAS Registry Number: 61-00-7 乙酰丙嗪

CAS Name: 1-[10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]ethanone
Additional Names: 10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl ketone; 2-acetyl-10-(3-dimethylaminopropyl)phenothiazine; 3-acetyl-10-(3-dimethylaminopropyl)phenothiazine; 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone; acetazine; acetopromazine; acetylpromazinePercent Composition: C 69.90%, H 6.79%, N 8.58%, O 4.90%, S 9.82%

📌 参考资料/链接：
Literature References: Prepn: J. Schmitt et al., Bull. Soc. Chim. Fr. 1957, 938. Pharmacology and toxicology: W. Wirth et al., Arch. Int. Pharmacodyn. 123, 78 (1959). GLC determn in plasma: S. Ballard, T. Tobin, J. Toxicol. Environ. Health 7, 745 (1981). Clinical trial in cats: D. H. Dyson et al., Can. Vet. J. 33, 462 (1992); in horses: A. Hashem, H. Keller, J. Vet. Pharmacol. Ther. 16, 359 (1993). Brief review of clinical experience: N. Brock, Can. Vet. J. 35, 458-459 (1994).

📄 详细内容

Properties: Yellow-colored oil, bp0.5 220-240°.
Boiling point: bp0.5 220-240°
Derivative Type: Maleate
CAS Registry Number: 3598-37-6
Trademarks: Atravet (Wyeth-Ayerst); Calmivet (Stricker); Plegicil (Sanofi); PromAce (Fort Dodge); Sedalin (Chassot); Vetranquil (Sanofi)
Percent Composition: C 62.42%, H 5.92%, N 6.33%, O 18.08%, S 7.25%
Properties: Yellow crystals from ethyl acetate, mp 135-136°. pKa 9.3. Sol in water, alcohol, chloroform. pH of aq solns: ~4.0. LD50 orally in rats: 400 mg/kg; i.v. in mice: 59 mg/kg (Wirth).
Melting point: mp 135-136°
pKa: pKa 9.3
Toxicity data: LD50 orally in rats: 400 mg/kg; i.v. in mice: 59 mg/kg (Wirth)
Therap-Cat-Vet: Tranquilizer.
产品链接: 61-00-7››

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