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CAS号6320-02-1 2-溴苯硫醇 | CAS号1628-29-1 10-乙酰基吩噻嗪 | CAS号92-84-2 吩噻嗪 | CAS号6632-11-7 Ethanone,1,1'-(... | CAS号6631-94-3 2-乙酰基吩噻嗪 | CAS号109-54-6 3-氯-1-(N,N-二甲基)丙胺 | CAS号59995-97-0 2-acetyl-phenot... | CAS号39481-55-5 1-(10-(3-氯丙基)-1... | CAS号124-40-3 二甲胺 | CAS号73644-43-6 2-(1-羟乙基)丙嗪

📜甲基吩噻嗪-10-基甲酮置于盐酸,三氯化铝,Sodium Hydride体系中,用 二硫化碳,乙醇 作为反应溶剂,化学反应 6.0H,反应生成 乙酰丙嗪
参考文献:锥虫嘧啶还原酶的吩噻嗪抑制剂可作为潜在的抗锥虫和抗疟药.
标题:锥虫嘧啶还原酶的吩噻嗪抑制剂可作为潜在的抗锥虫和抗疟药.
摘要:鉴于锥虫硫磷在致病性锥虫和利什曼原虫的氧化还原防御中的作用,与谷胱甘肽作为哺乳动物宿主相比,锥虫硫磷还原酶的选择性抑制剂是对抗锥虫病和利什曼病的潜在药物.在本研究中,合理的药物设计方法被用于发现三环抗精神病药物分子框架,作为开发抑制剂的先导结构,对宿主的谷胱甘肽还原酶具有选择性的锥虫硫醇还原酶选择性.根据锥虫还原酶的同源模型结构,在研究的后期阶段,用crisidia Fasciculata的酶的x射线坐标代替,设计了一系列基于吩噻嗪的抑制剂.这些物质被证明是克氏锥虫中锥虫硫醇还原酶的可逆抑制剂,与锥虫硫磷作为底物线性竞争,与nadph不竞争,这与乒乓球的bi Bi动力学一致.合成以定义活性位点的结构-活性关系的类似物包括n-酰基吡嗪,2-取代的吩噻嗪和三取代的丙嗪.根据计算出的log P和摩尔折光率值对ki和i50数据进行分析,提供了特别有利的小2-取代基(尤其是2-氯和2-三氟甲基)与酶
DOI:10.1021/jm960814J

专利信息

专利号:US-4923851-A
优先权日:1987-12-29
标 题:Composition of matter for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair
发明人：CARNIGLIA FRANCIS J
权利人:RONCARI RAYMOND A
摘要:A composition of matter for increasing the intracellular synthesis of ATP. The composition consists of amino acids, metabolites, electrolyte and a pentose sugar. When applied to wounds, the invention increases the rate of wound repair. When administered orally, the invention increases ATP blood levels and physical performance levels.

专利号:US-9913926-B2
优先权日:2008-01-24
标题 :Adhesive complex coacervates and method of making and using thereof
发明人：STEWART RUSSELL J; SHAO HUI
权利人:STEWART RUSSELL J; SHAO HUI; UNIV UTAH RES FOUND
摘要:Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. They have numerous biological applications as bioadhesives and drug delivery devices and are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.

专利号:US-9272069-B2
优先权日:2008-01-24
标 题:Adhesive complex coacervates and methods of making and using thereof
发明人：STEWART RUSSELL; SHAO HUI
权利人:STEWART RUSSELL; SHAO HUI; UNIV UTAH RES FOUND
摘要:Described herein is the synthesis of adhesive complex coacervates. The adhesive complex coacervates are composed of a mixture of one or more polycations, one or more polyanions, and one of more multivalent cations. The polycations and polyanions in the adhesice complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applicatgions. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.

专利号:US-5391550-A
优先权日:1987-12-29
标题 :Compositions of matter and methods for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair
发明人：CARNIGLIA FRANCIS J; KENYON ALAN J
权利人:RONCARI RAYMOND A
摘要:Disclosed are methods and compositions of matter for increasing the intracellular synthesis of ATP. The compositions comprise amino acids, metabolites, electrolyte and/or a pentose sugar. When applied to wounds, the invention increases the rate of wound repair and has a antimicrobial effect. When administered orally, the invention increases ATP blood levels and physical performance levels.

专利号:US-7741435-B2
优先权日:1997-07-09
标题 :Substance P-saporin (SP-SAP) conjugates and methods of use thereof
发明人：LAPPI DOUGLAS A; WILEY RONALD G
权利人:ADVANCED TARGETING SYSTEMS INC
摘要:This invention provides a conjugate comprising Substance P, or an analog thereof, and a protein, such as Saporin, that inhibits protein synthesis. n This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective amount of the pharmaceutical composition of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to reduce the perception of pain by the subject. n This invention provides a method of selectively destroying NK-1R-expressing neuronal cells in a subject comprising administering to the subject an effective amount of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to selectively destroy NK-1R-expressing neuronal cells. n Lastly, this invention provides a method for treating a NK-1R-associated disorder in a subject, which comprises administering to the subject an amount of the pharmaceutical composition comprising substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, in an effective amount to treat the disorder associated with the NK-1R.

专利号:WO-2012076696-A1
优先权日:2010-12-09
标 题 :New metal carbonyl complexes of curcumin derivatives, their synthesis and their uses in therapeutic application
发明人：MOTTERLINI ROBERTO; BRULE EMILIE; AREZKI ANUSCH; LE BIDEAU FRANCK; JAOUEN GERARD; BOCZKOWSKI JORGE
权利人:UNIV PARIS CURIE; CENTRE NAT RECH SCIENT; MOTTERLINI ROBERTO; BRULE EMILIE; AREZKI ANUSCH; LE BIDEAU FRANCK; JAOUEN GERARD; BOCZKOWSKI JORGE
摘要:The present invention relates to new metal carbonyl complexes of curcumin derivatives, their synthesis and their uses in therapeutic application.