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Glisoxepid CAS Registry Number: 25046-79-1 格列派特

CAS Name: N-[2-[4-[[[[(Hexahydro-1H-azepin-1-yl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-3-isoxazolecarboxamide
Additional Names: 1-(hexahydro-1H-azepin-1-yl)-3-[[p-[2-(5-methyl-3-isoxazolecarboxamido)ethyl]phenyl]sulfonyl]urea; 4-[4-[b-(5-methylisoxazole-3-carboxamido)ethyl]phenylsulfonyl]-1,1-hexamethylenesemicarbazideTrademarks: Pro-Diaban (Bayer; Schering AG)
Percent Composition: C 53.44%, H 6.05%, N 15.58%, O 17.80%, S 7.13%

📌 参考资料/链接：
Literature References: Prepn: H. Plümpe, W. Puls, ZA 6806886; eidem, US 3668215 (1969, 1972 both to Bayer). Pharmacology: Loubatieres et al., C.R. Seances Acad. Sci. Ser. D 271, 1446 (1970); J. Pharmacol. 3, 171, 229 (1972). Toxicity study: Tettenborn, Arzneim.-Forsch. 24, 409 (1974). Series of articles: ibid. 363-452.

📄 详细内容

Properties: Colorless crystals from ethanol, mp 189°. LD50 in mice, rats, cats, dogs (g/kg): 10.0, 10.0, 4.0, 2.0 orally; in mice, rats (mg/kg): 283, 196 i.v. (Tettenborn).
Melting point: mp 189°
Toxicity data: LD50 in mice, rats, cats, dogs (g/kg): 10.0, 10.0, 4.0, 2.0 orally; in mice, rats (mg/kg): 283, 196 i.v. (Tettenborn)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives.
产品链接: 25046-79-1››

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