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Everolimus CAS# 159351-69-6 依维莫司
Everolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK ...
Polymer compositions containing a macrocyclic triene compound; Shulze, John E.; Betts, Ronald E.; Savage, Douglas R.; Assignee Sun Bow Co., Ltd., Bermuda; Sun Biomedical Ltd. 2003; Patent Information; Nov 06, 2003; WO 2003090684 A2
etripamil CAS# 1593673-23-4 艾曲帕米
Etripamil is a potent, short‑acting L‑type calcium channel blocker that inhibits calcium influx and prolongs atrioventricular nodal refractory periods in vitro via Cav1.2/Cav1.3 channel blockade (elec...
Das, Arijit; Mudgal, Shrikant Suresh; Patil, Chandrajeet Dattatraya; Sawant, Pratap Ramesh. Process for synthesis of Etripamil and use of Etripamil or its pharmaceutically acceptable salt for treatment of paroxysmal supraventricular tachycardia (2024).
Ulipristal CAS# 159811-51-5 乌利司他
Ulipristal acetate, also known as CDB-2914, is a selective progesterone receptor modulator (SPRM) approved for contraception, and for uterine fibroid. As a SPRM, ulipristal acetate has partial agonist...
Kim, Hyun K.; Rao, Pemmaraju Narasinha; Burdett, James E., Jr.; Acosta, Carmie Kirk. improved preparation of 17α-acetoxy-11β-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione and its intermediates. Assignee United States Dept. of Health and Human Services, USA. WO 9630390. (1996).
Deucravacitinib CAS# 1609392-27-9
Deucravacitinib (BMS-986165) is a selective, oral allosteric inhibitor of tyrosine kinase 2 (TYK2). Unlike JAK1/2/3 inhibitors, it binds the regulatory pseudokinase (JH2) domain of TYK2 with high affi...
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165By: Wrobleski, Stephen T. ; et alJournal of Medicinal Chemistry (2019), 62(20), 8973-8995
Silodosin CAS# 160970-54-7 西洛多辛
Silodosin is an α1-adrenoceptor antagonist approved for the symptomatic treatment of benign prostatic hyperplasia. It acts as an α1-adrenoceptor antagonist with high uroselectivity (selectivity for t...
Yamaguchi, Toshiaki; Tsuchiya, Ikuo; Kikuchi, Ken; Yanagi, Takashi. Process for preparation of silodosin. Assignee Kissei Pharmaceutical Co., Ltd., Japan. WO 2006046499. (2006).
Bictegravir CAS# 1611493-60-7 比克替拉韦
Bictegravir (GS-9883) is a potent second-generation HIV-1 integrase strand transfer inhibitor (INSTI) with strong activity in preclinical models. In vitro, it demonstrates low nanomolar inhibitory con...
Three-step synthetic procedure to prepare dolutegravir, cabotegravir, and bictegravirBy: Wang, Xianheng; et alGreen Chemistry Letters and Reviews (2022), 15(2), 312-319
Dordaviprone CAS# 1616632-77-9 2,4,6,7,8,9-六氢-4-[(2-甲基苯基)甲基]-7-苄基咪唑并[1,2-a]吡啶并[3,4-e]嘧啶-5(1H)-酮
Dordaviprone, also known as ONC-201 and TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrie...
Tandem copper catalyzed regioselective N-arylation-amidation: synthesis of angularly fused dihydroimidazoquinazolinones and the anticancer agent TIC10/ONC201By: Honnanayakanavar, Jyoti M.; et alOrganic & Biomolecular Chemistry (2021), 19(39), 8497-8501
Amprenavir CAS# 161814-49-9 安普那韦
Amprenavir (original brand name Agenerase, GlaxoSmithKline) is a protease inhibitor used to treat HIV infection. The mechanism of action of amprenavir is as a HIV Protease Inhibitor and Cytochrome P45...
Kim, B. Moon; Bae, Sung Jin; So, Soon Mog; Yoo, Hyun Tae; Chang, Sun Ki; Lee, Jung Hwan; Kang, JaeSung. Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors. Organic Letters. Volume 3. Issue 15. Pages 2349-2351. 2001.
Zoliflodacin CAS# 1620458-09-4 唑利氟达星
Zoliflodacin, also known as AZD0914 and ETX0914, is a new spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor with potent in vitro antibacterial activity against key Gram-positive (Sta...
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)By: Basarab, Gregory S.; et alJournal of Medicinal Chemistry (2015), 58(15), 6264-6282
Envonalkib CAS# 1621519-26-3
Envonalkib (TQ-B3139) is a potent, orally bioavailable ALK tyrosine kinase inhibitor with demonstrated efficacy in both in vitro and in vivo models. In preclinical studies, it exhibited high potency a...
Patent#: WO2017016514
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