1. 智能化融合:发展数据挖掘、集成、分析、可视化及人工智能工具,实现数据与文献、模型、计算等资源的有机融合,促进领域数智驱动科研新范式变革.
2. 标准化体系建设:以统一的数据标准管理体系为基础,系统整合全链条多源异构数据,聚焦高价值业务需求,精准构建结构合理、标注规范、语义清晰的数据资源.
3. 开放共享生态:开展数据提供方、使用方和服务方生态体系建设,实现多元主体间数据共享、共用、共治。.
4. 多模态数据处理:构建“全模态数据治理平台+高质量数据服务”一体化解决方案,提升非结构化数据处理能力.

Daridorexant, also known as Nemorexant and ACT541468, is a new dual orexin receptor antagonist, used in the treatment of Insomnia Disorder in Adult Patients. By specific binding to both orexin recepto...
Assignee: Nanjing Zhihe Pharmaceutical Technology Co., Ltd.China, CN115925699 A 2023-04-07
Tolvaptan is a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of in...
Cordero-Vargas, Alejandro; Quiclet-Sire, Beatrice; Zard, Samir Z. A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan. Bioorganic & Medicinal Chemistry. Volume 14. Issue 18. Pages 6165-6173. 2006.
Ezogabine, also known as Retigabine, is an anticonvulsant used as an adjunctive treatment for partial epilepsies in treatment-experienced adult patients. The drug was developed by Valeant Pharmaceutic...
Zhu, Lei; Wang, Jia-le; Wang, Pu-hai. Improved synthesis of retigabine. Zhongguo Yaowu Huaxue Zazhi. Volume 24. Issue 1. Pages 31-33, 77. Journal. (2014).
Pemigatinib (INCB054828) is a potent, ATP-competitive inhibitor of FGFR1–3, with IC₅₀ values of approximately 0.4, 0.4, and 1 nM, respectively, and minimal activity against FGFR4 (IC₅₀ ~30 nM). In vit...
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) InhibitorBy: Wu, Liangxing; et alJournal of Medicinal Chemistry (2021), 64(15), 10666-10679
Deuruxolitinib (CP-543) demonstrates potent and selective bioactivity, functioning as a nanomolar-range inhibitor of Janus kinases JAK1 and JAK2 in vitro, with IC50 values of approximately 2.4 nM and ...
Patent#: WO2022036030
Umbralisib is a dual inhibitor of PI3Kδ (phosphoinositide 3-kinase delta) and casein kinase 1 epsilon (CK1ε), enzymes involved in the regulation of cell survival and proliferation in hematologic malig...
Patent#: WO2014006572
Reference: Cagulada, Amy; Chan, Johann; Chan, Lina; Colby, Denise A.; Karki, Kapil Kumar; Kato, Darryl; Keaton, Katie Ann; Kondapally, Sudha; Levins, Chris; Littke, Adam; Martinez, Ruben; Pcion, Dominika; Reynolds, Troy; Ross, Bruce; Sangi, Michael; Schrier, Adam J.; Seng, Pamela; Siegel, Dustin; Shapiro, Nathan; Tang, Donald; Taylor, James G.; Tripp, Jonathan; Waltman, Andrew W.; Yu, Lawrence. Synthesis of an antiviral N-(3-ethyl)prolyl-1-aminocyclopropanecarboxylic acid peptide and new routes to its difluoromethylaminocyclopropanecarboxylic acid intermediate. Assignee Gilead Sciences, Inc., USA. US 20150175626. (2015).
Bexarotene, also known as LGD-1069, is a synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activ...
Wagner, Carl E.; Jurutka, Peter W.; Marshall, Pamela A.; Groy, Thomas L.; van der Vaart, Arjan; Ziller, Joseph W.; Furmick, Julie K.; Graeber, Mark E.; Matro, Erik; Miguel, Belinda V.; Tran, Ivy T.; Kwon, Jungeun; Tedeschi, Jamie N.; Moosavi, Shahram; Danishyar, Amina; Philp, Joshua S.; Khamees, Reina O.; Jackson, Jevon N.; Grupe, Darci K.; Badshah, Syed L.; Hart, Justin W. Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene). Journal of Medicinal Chemistry. Division of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences. Arizona State University. Glendale, USA 85306. Volume 52. Issue 19. Pages 5950-5966. 2009
Abiraterone acetate is an FDA approved drug, and is an orally active acetate ester of the steroidal compound abiraterone with antiandrogen activity. Abiraterone acetate was approved by the U.S. Food a...
Madhra, Mukesh Kumar; Sriram, Hari Mohan; Inamdar, Murad; Sharma, Mukesh Kumar; Prasad, Mohan; Joseph, Sony. Improved Procedure for Preparation of Abiraterone Acetate. Organic Process Research & Development. Volume 18. Issue 4. Pages 555-558. Journal; Online Computer File. (2014).
Alvimopan, also known as HSDB-7704 and LY246736, is a drug which behaves as a peripherally acting μ-opioid antagonist. With limited ability to cross the blood–brain barrier, many of the undesirable si...
Ravilla, Lokesh; Venkata subba Naidu, N.; Dogra, Shalini; Umrao, Deepmala; Yadav, Prem N.; Biswas, Ansuman; Michael, Daliah; Sekar, Kanagaraj; Nagarajan, Kuppuswamy Journal of Medicinal Chemistry Volume 60 Issue 15 Pages 6733-6750 Journal 2017
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