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Abrocitinib CAS# 1622902-68-4 (cis-isomer) PF-04965842(阿布罗替尼)
Abrocitinib, an oral selective Janus kinase 1 (JAK1) inhibitor, showed potent preclinical activity in modulating cytokine signaling relevant to inflammatory diseases. In enzymatic assays, it inhibited...
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune DiseasesBy: Vazquez, Michael L. ; Kaila, Neelu; Strohbach, Joseph W.; Trzupek, John D.; Brown, Matthew F.; et alJournal of Medicinal Chemistry (2018), 61(3), 1130-1152
Fingolimod CAS# 162359-55-9 芬戈莫德
Fingolimod is used to treat multiple sclerosis, and has antineoplastic activity.
Shaikh, Rizwan S.; Schilson, Stefanie S.; Wagner, Stefan; Hermann, Sven; Keul, Petra; Levkau, Bodo; Schaefers, Michael; Haufe, Guenter. Synthesis and Evaluation of Fluorinated Fingolimod (FTY720) Analogues for Sphingosine-1-Phosphate Receptor Molecular Imaging by Positron Emission Tomography. Journal of Medicinal Chemistry. Volume 58. Issue 8. Pages 3471-3484. Journal; Online Computer File. (2015).
Temsirolimus CAS# 162635-04-3 西罗莫司脂化物
Temsirolimus is an ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progressi...
Gu, Jianxin; Ruppen, Mark E.; Raveendranath, Panolil; Chew, Warren; Shaw, Chia-Cheng. Production of rapamycin 42-ester with 2,2-bis(hydroxymethyl)propionic acid (CCI-779) and its proline analog. Assignee Wyeth, USA. US 20050234086. (2005).
Sofpironium bromide CAS# 1628106-94-4
Sofpironium, also known as BBI-4000, belongs to a class of drugs called ‘anticholinergics,’ which exert their effect by blocking the action of acetylcholine, a chemical that transmits signals within t...
Patent#: WO2018026869
Pafolacianine CAS# 1628423-76-6
Pafolacianine, also known as OTL0038 and OTL-38, is a folate receptor-directing imaging agent. OTL0038 accumulated at sites of inflammation in animal models. OTL-0038 displays high affinity and speci...
A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacyBy: Abdelaal, Ahmed M.; et alOncogene (2023), 42(40), 2985-2999
Vimseltinib CAS# 1628606-05-2
Vimseltinib, also known as DCC-3014, is a potent and orally active inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; C-FMS; CD115; M-CSFR), with potential...
Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)By: Caldwell, Timothy M.; et alBioorganic & Medicinal Chemistry Letters (2022), 74, 128928
Fezolinetant CAS# 1629229-37-3 非唑奈坦
Fezolinetant, also known as ESN-364, is Neurokinin-3 (NK-3) receptor antagonist which has been optimized for use in women’s health, and is being developed for sex-hormone related disorders such as end...
Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II)By: Hoveyda, Hamid R.; et alACS Medicinal Chemistry Letters (2015), 6(7), 736-740
Rezafungin Acetate CAS# 1631754-41-0
Rezafungin acetate (CD101) is a next-generation echinocandin antifungal that inhibits fungal β-(1,3)-D-glucan synthase. In preclinical enzyme assays, it blocked glucan synthesis with IC₅₀ values in th...
Benzylic Dehydroxylation of Echinocandin Antifungal Drugs Restores Efficacy against Resistance Conferred by Mutated Glucan SynthaseBy: Logviniuk, Dana ; et alJournal of the American Chemical Society (2022), 144(13), 5965-5975
Mavacamten CAS# 1642288-47-8 玛伐凯泰
Mavacamten (MYK-461) is a first-in-class, selective small-molecule inhibitor of cardiac myosin ATPase developed for hypertrophic cardiomyopathy. In preclinical studies, it reduced myosin-actin cross-b...
Process for preparing Mavacamten and process intermediateInventors: Ricci, Benedetta; et alWorld Intellectual Property OrganizationPatent Number#WO2025027567
Fosnetupitant chloride HCl CAS# 1643757-72-5 盐酸磷奈妥匹坦*
Fosnetupitant is a neurokinin receptor antagonist. Neurokinin 1 (NK1) receptor antagonists (RAs) are a class of drug used to treat nausea and vomiting associated with chemotherapy. Aprepitant, casopit...
Fadini, Luca; Manini, Peter; Pietra, Claudio; Giuliano, Claudio; Lovati, Emanuela; Cannella, Roberta; Venturini, Alessio; Stella, Valentino. (Assignee: Helsinn Healthcare SA, Switz). Substituted 4 - phenyl - pyridines for the treatment of nk-1 receptor related diseases. WO2013082102 (2013).
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