Pafolacianine CAS# 1628423-76-6

Pafolacianine, also known as OTL0038 and OTL-38, is a folate receptor-directing imaging agent. OTL0038 accumulated at sites of inflammation in animal models. OTL-0038 displays high affinity and specificity for FRs and was shown (i) to accumulate in vivo in tumor cells expressing FRs, and (ii) to be non-toxic in mice at clinical dose x 1000. OTL0038 has the ability to predict responses to multiple therapies in four murine models of inflammation. Pafolacianine was approved to identify ovarian cancer lesions.