CAS: 1628423-76-6; Pafolacianine
- 英文名称Pafolacianine
- 中文名称2-((E)-2-((E)-2-(4-((S)-2-(4-(((2-氨基-4-氧代-3,4-二氢蝶啶-6-基)甲基)氨基)苯甲酰氨基)-2-羧基乙基)苯氧基)-3-(2-((E)-3,3-二甲基-5-磺酰氯-1-(4-磺基丁基)吲哚-2-亚基)亚乙基)环己-1-烯-1-基)乙烯基)-3,3-二甲基-1-(4-磺基丁基)-3H-吲哚-1-咪唑-5-磺酸盐
- IUPAC名称2-((E)-2-((E)-2-(4-((S)-2-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-2-carboxyethyl)phenoxy)-3-(2-((E)-3,3-dimethyl-5-sulfo-1-(4-sulfobutyl)indolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfobutyl)-3H-indol-1-ium-5-sulfonate
- 其它别名Pafolacianine Otl-38; Pafolacianine
- CAS编号1628423-76-6
- FDA UNII编号:F7BD3Z4X8L
- 分子式:C61H67N9O17S4分子量:1326.52
- 产品CID: 824480
- 同类组份化合物CAS1628858-03-6 (sodium)1628423-76-6 (free acid)
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
2902600000-乙苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-9789208-B2
优先权日:2013-03-15
标 题:Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
发明人：KULARATNE SUMITH A
权利人:PURDUE RESEARCH FOUNDATION
摘要:The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.
专利号:US-10881747-B2
优先权日:2013-03-15
标题:Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
专利号:US-9333270-B2
优先权日:2013-03-15
标题:Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
专利号:US-9341629-B2
优先权日:2013-03-15
标题 :Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
专利号:US-9061057-B2
优先权日:2013-03-15
标题:Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
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主要参考文献
1: Muynck LDAN, Gaarenstroom KN, Sier CFM, Duijvenvoorde MV, Bosse T, Mieog JSD, Kroon CD, Vahrmeijer AL, Peters ITA. Novel Molecular Targets for Tumor-Specific Imaging of Epithelial Ovarian Cancer Metastases. Cancers (Basel). 2020 Jun 12;12(6):1562. doi: 10.3390/cancers12061562.
2: Boogerd LSF, Hoogstins CES, Gaarenstroom KN, de Kroon CD, Beltman JJ, Bosse T, Stelloo E, Vuyk J, Low PS, Burggraaf J, Vahrmeijer AL. Folate receptor-α targeted near-infrared fluorescence imaging in high-risk endometrial cancer patients: a tissue microarray and clinical feasibility study. Oncotarget. 2017 Dec 11;9(1):791-801. doi: 10.18632/oncotarget.23155.
3: Bahler CD, Maniar V, Marley KN, Kheyfets SV, Shum CF, Sundaram CP. OTL-38-Guided Fluorescent Imaging in Renal Cell Cancer Robotic Partial Nephrectomy. J Endourol B Videourol. 2017 Feb 6;31(3):vid.2016.0068. doi: 10.1089/vid.2016.0068.
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