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Pralatrexate CAS# 146464-95-1 普拉曲沙
Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralat...
DeGraw, Joseph I.; Colwell, William T.; Piper, James R.; Sirotnak, Francis M. Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin. Journal of Medicinal Chemistry. Volume 36. Issue 15. Pages 2228-31. 1993.
Alcaftadine CAS# 147084-10-4 阿卡他定
Alcaftadine is used to prevent eye irritation brought on by allergic conjunctivitis. It is a H1 histamine receptor antagonist. It was approved by the U.S. Food and Drug Administration in 2010 under th...
Ponnaiah, Ravi; Hashmi, Arshad Moosa; Neela, Praveen Kumar; Seemala, Dhanunjaya Naidu; Mokka, Raviteja; Lahoti, Anandkumar Madanlal; Deepthi, V. P. S. S.; Saradhi, G. Srinivas Pardha. A process for the preparation of alcaftadine (Assignee Neuland Laboratories Limited, India). 2014 Patent Information. Jun 05, 2014. WO 2014083571 A1
Omaveloxolone CAS# 1474034-05-3 奥马索龙
Omaveloxolone is a semi-synthetic oleanane triterpenoid that activates Nrf2 by disrupting Keap1–Nrf2 binding. In biochemical and cellular assays, it increased Nrf2-driven antioxidant response element ...
Synthesis of omaveloxoloneAssignee: Reata Pharmaceuticals Holdings, LLCInventors: Bates, Craig G.; et alWorld Intellectual Property OrganizationPatent#WO2025029691 A1
Pitavastatin (Calcium) CAS# 147511-69-1 / 147526-32-7 匹伐他汀
Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox. In addition, pitava...
Yagi, Yusuke; Kimura, Hiroyuki; Arimitsu, Kenji; Ono, Masahiro; Maeda, Kazuya; Kusuhara, Hiroyuki; Kajimoto, Tetsuya; Sugiyama, Yuichi; Saji, Hideo. The synthesis of [18F]pitavastatin as a tracer for hOATP using the Suzuki coupling. Organic & Biomolecular Chemistry. Volume 13. Issue 4. Pages 1113-1121. 2015.
Bosentan CAS# 147536-97-8 波生坦
Bosentan is a mixed Endothelin Receptor Antagonist which is used as a vasodilator. Bosentan is an inhibitor of ETAR and ETBR. It is used for the treatment of pulmonary artery hypertension (PAH). Bosen...
Raju, K. Rajasekhara; Reddy, B. Shankar; Somannavar, Y. S.; Sinha, B. K.; Babu, P. N. Kishore; Raju, K. Mohana. Improved Large-Scale Synthesis of Bosentan Monohydrate. Organic Preparations and Procedures International. Chemical Research and Development. Aurobindo Pharma Ltd. Telangana, India. Volume 48. Issue 6. Pages 481-491. 2016
Asciminib CAS# 1492952-76-7 阿思尼布
Asciminib, also known as ABL001, is a potent allosteric inhibitor of BCR-ABL. ABL001 prevents emergence of resistant disease when administered in combination with nilotinib in an in vivo murine model ...
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1By: Wylie, Andrew A.; et alNature (London, United Kingdom) (2017), 543(7647), 733-737
Sacubitril CAS# 149709-62-6 沙库比曲
Sacubitril, also known as AHU377, is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ65...
Reference: Zhang, Bo; Ding, Xiaohua; Dai, Dongcheng; Lei, Sijun; Liu, Xueming; Duan, Panpan; Chen, Yongkai; Wang, Chaodong. Preparation of crystal form and amorphous form of AHU-377 ammonium salt. WO 2018196860. (Wuhan Ll Science and Technology Development Co., Ltd., Peop. Rep. China; Wuhan Qr Pharmaceuticals Co., Ltd)
Prasugrel CAS# 150322-43-3 普拉格雷
Prasugrel (marketing name Effient in the US, Efient in the EU and Prasita in India) is a novel platelet inhibitor developed by Daiichi Sankyo Co. and produced by Ube and currently marketed in the Unit...
Padi, Pratap Reddy; Peri, Seetha Rama Sarma; Ganta, Madhusudhan Reddy; Polavarapu, Srinivas; Cherukupally, Praveen; Ireni, Babu; Padamata, Shailaja; Jonnada, Krishna; Vinigari, Krishna; Nerella, Kavitha. A process for preparing prasugrel and its salts and polymorphs. Assignee Dr. Reddy's Laboratories Ltd., India; Dr. Reddy's Laboratories, Inc. WO 2009062044. (2009).
Balsalazide Disodium CAS# 150399-21-6 巴柳氮二钠
Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Mesalaz...
Khan, Md. Umar; Baseer, M. A.; Kumar, S. Ranjith; Saravanakumar, M.; Prasannanjali, A. G.; Gupta, P. Badarinadh; Kaushik, Vipin K.; Handa, Vijay K.; Islam, Aminul. Synthesis and Characterization of Metabolites and Potential Impurities of Balsalazide Disodium, an Anti-Inflammatory Drug. Synthetic Communications. Chemical Research and Development Department, APL Research Centre. Aurobindo Pharma Ltd. Hyderabad, India 500 072. Volume 40. Issue 15. Pages 2241-2253. 2010
Setmelanotide Acetate CAS# 1504602-49-6
Setmelanotide acetate (RM-493) is a potent, selective melanocortin-4 receptor (MC4R) agonist developed for rare genetic obesity disorders. In preclinical assays, it activated human MC4R with an EC50 o...
Process for the synthesis of melanocortin analog Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2Assignee: Ipsen Pharma S.A.SInventor: Dong, Zheng XinWorld Intellectual Property OrganizationPatent#WO2011060355
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